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    TNFRSF13B TNF receptor superfamily member 13B [ Homo sapiens (human) ]

    Gene ID: 23495, updated on 12-Sep-2021

    Summary

    Official Symbol
    TNFRSF13Bprovided by HGNC
    Official Full Name
    TNF receptor superfamily member 13Bprovided by HGNC
    Primary source
    HGNC:HGNC:18153
    See related
    Ensembl:ENSG00000240505 MIM:604907
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CVID; RYZN; TACI; CD267; CVID2; IGAD2; TNFRSF14B
    Summary
    The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in spleen (RPKM 10.1), lymph node (RPKM 5.1) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TNFRSF13B in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (16939081..16972118, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (16842395..16875432, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929105 Neighboring gene TBC1 domain family member 27, pseudogene Neighboring gene uncharacterized LOC284191 Neighboring gene long intergenic non-protein coding RNA 2090

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese.
    GeneReviews: Not available
    Common variable immunodeficiency 2
    MedGen: C3150354 OMIM: 240500 GeneReviews: Not available
    Compare labs
    Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.
    GeneReviews: Not available
    Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
    GeneReviews: Not available
    Genome-wide association study identifies common variants at TNFRSF13B associated with IgG level in a healthy Chinese male population.
    GeneReviews: Not available
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    GeneReviews: Not available
    Genome-wide association study of serum albumin:globulin ratio in Korean populations.
    GeneReviews: Not available
    Genome-wide meta-analysis for severe diabetic retinopathy.
    GeneReviews: Not available
    Immunoglobulin A deficiency 2
    MedGen: C1836032 OMIM: 609529 GeneReviews: Not available
    Compare labs

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ39942, MGC39952, MGC133214

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in hematopoietic progenitor cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of B cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor receptor superfamily member 13B
    Names
    transmembrane activator and CAML interactor
    tumor necrosis factor receptor 13B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007281.1 RefSeqGene

      Range
      5001..38005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_120

    mRNA and Protein(s)

    1. NM_012452.3NP_036584.1  tumor necrosis factor receptor superfamily member 13B

      See identical proteins and their annotated locations for NP_036584.1

      Status: REVIEWED

      Source sequence(s)
      AC104024, AL353996
      Consensus CDS
      CCDS11181.1
      UniProtKB/Swiss-Prot
      O14836
      UniProtKB/TrEMBL
      Q4ACX1
      Related
      ENSP00000261652.2, ENST00000261652.7
      Conserved Domains (1) summary
      cd13415
      Location:34245
      TNFRSF13B; Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B), also known as transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      16939081..16972118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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