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    NCAPH non-SMC condensin I complex subunit H [ Homo sapiens (human) ]

    Gene ID: 23397, updated on 20-Dec-2019

    Summary

    Official Symbol
    NCAPHprovided by HGNC
    Official Full Name
    non-SMC condensin I complex subunit Hprovided by HGNC
    Primary source
    HGNC:HGNC:1112
    See related
    Ensembl:ENSG00000121152 MIM:602332
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAPH; BRRN1; CAP-H; MCPH23
    Summary
    This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2013]
    Expression
    Biased expression in testis (RPKM 8.6), bone marrow (RPKM 4.4) and 11 other tissues See more
    Orthologs

    Genomic context

    See NCAPH in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (96335766..96377091)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (97001479..97042833)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein U5 subunit 200 Neighboring gene Sharpr-MPRA regulatory region 61 Neighboring gene ITPRIP like 1 Neighboring gene neuralized E3 ubiquitin protein ligase 3 Neighboring gene uncharacterized LOC105373496

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Interaction of HIV-1 Tat with CAPH in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA topoisomerase (ATP-hydrolyzing) activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA topoisomerase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    female meiosis chromosome separation IEA
    Inferred from Electronic Annotation
    more info
     
    meiotic chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic chromosome condensation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    condensin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    membrane HDA PubMed 
    nuclear condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    condensin complex subunit 2
    Names
    barren homolog 1
    chromosome-associated protein H

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281710.2NP_001268639.1  condensin complex subunit 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC021188, AK308050, D38553
      UniProtKB/Swiss-Prot
      Q15003
      Conserved Domains (1) summary
      pfam05786
      Location:44727
      Cnd2; Condensin complex subunit 2
    2. NM_001281711.2NP_001268640.1  condensin complex subunit 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC021188, AK299248, D38553
      UniProtKB/Swiss-Prot
      Q15003
      UniProtKB/TrEMBL
      B4DRG7
      Conserved Domains (1) summary
      pfam05786
      Location:31714
      Cnd2; Condensin complex subunit 2
    3. NM_001281712.2NP_001268641.1  condensin complex subunit 2 isoform 4

      See identical proteins and their annotated locations for NP_001268641.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon in the coding region and initiates translation at an alternate start codon compared to variant 1. The resulting protein (isoform 4) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC021188, AK303725
      Consensus CDS
      CCDS62960.1
      UniProtKB/Swiss-Prot
      Q15003
      Related
      ENSP00000400774.1, ENST00000427946.5
      Conserved Domains (1) summary
      pfam05786
      Location:1602
      Cnd2; Condensin complex subunit 2
    4. NM_015341.5NP_056156.2  condensin complex subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_056156.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AC021188, D38553
      Consensus CDS
      CCDS2021.1
      UniProtKB/Swiss-Prot
      Q15003
      Related
      ENSP00000240423.4, ENST00000240423.9
      Conserved Domains (1) summary
      pfam05786
      Location:55738
      Cnd2; Condensin complex subunit 2

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      96335766..96377091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712388.4XP_006712451.1  condensin complex subunit 2 isoform X2

      Conserved Domains (1) summary
      pfam05786
      Location:55707
      Cnd2; Condensin complex subunit 2
    2. XM_005263908.4XP_005263965.1  condensin complex subunit 2 isoform X1

      Related
      ENSP00000407308.1, ENST00000455200.5
      Conserved Domains (1) summary
      pfam05786
      Location:55722
      Cnd2; Condensin complex subunit 2
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