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    SNX13 sorting nexin 13 [ Homo sapiens (human) ]

    Gene ID: 23161, updated on 5-Aug-2018

    Summary

    Official Symbol
    SNX13provided by HGNC
    Official Full Name
    sorting nexin 13provided by HGNC
    Primary source
    HGNC:HGNC:21335
    See related
    Ensembl:ENSG00000071189 MIM:606589; Vega:OTTHUMG00000152730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RGS-PX1
    Summary
    This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 8.8), testis (RPKM 6.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See SNX13 in Genome Data Viewer
    Location:
    7p21.1
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (17790761..17940508, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (17830385..17980141, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene renal clear cell carcinoma-associated transcript 333 Neighboring gene uncharacterized LOC105375172 Neighboring gene uncharacterized LOC101927630 Neighboring gene RNA methyltransferase like 1 pseudogene 2 Neighboring gene phosphoribosyl pyrophosphate synthetase 1-like 1

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0713

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    sorting nexin-13
    Names
    rgs domain- and phox domain-containing protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001350862.1NP_001337791.1  sorting nexin-13 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC073205, AC080080
      Related
      ENSP00000479044.1, ENST00000611725.4
      Conserved Domains (4) summary
      cd06873
      Location:557687
      PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
      cd08719
      Location:377511
      RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
      smart00313
      Location:97284
      PXA; Domain associated with PX domains
      pfam08628
      Location:803911
      Nexin_C; Sorting nexin C terminal
    2. NM_001350863.1NP_001337792.1  sorting nexin-13 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC073205, AC080080
      Conserved Domains (4) summary
      cd06873
      Location:477596
      PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
      cd08719
      Location:297431
      RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
      smart00313
      Location:17204
      PXA; Domain associated with PX domains
      pfam08628
      Location:712820
      Nexin_C; Sorting nexin C terminal
    3. NM_001350864.1NP_001337793.1  sorting nexin-13 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), encodes isoform d.
      Source sequence(s)
      AC073205, AC080080
      Conserved Domains (4) summary
      cd06873
      Location:455574
      PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
      cd08719
      Location:275409
      RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
      pfam08628
      Location:690798
      Nexin_C; Sorting nexin C terminal
      cl02564
      Location:45182
      PXA; PXA domain
    4. NM_001350866.1NP_001337795.1  sorting nexin-13 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 7, encodes isoform e.
      Source sequence(s)
      AC073205, AC080080
      Conserved Domains (4) summary
      cd06873
      Location:354473
      PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
      cd08719
      Location:174308
      RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
      pfam08628
      Location:589697
      Nexin_C; Sorting nexin C terminal
      cl02564
      Location:1381
      PXA; PXA domain
    5. NM_001350867.1NP_001337796.1  sorting nexin-13 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variant 6, encodes isoform e.
      Source sequence(s)
      AC073205, AC080080
      Conserved Domains (4) summary
      cd06873
      Location:354473
      PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
      cd08719
      Location:174308
      RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
      pfam08628
      Location:589697
      Nexin_C; Sorting nexin C terminal
      cl02564
      Location:1381
      PXA; PXA domain
    6. NM_001350868.1NP_001337797.1  sorting nexin-13 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC073205, AC080080
      Conserved Domains (2) summary
      cd08719
      Location:377511
      RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
      smart00313
      Location:97284
      PXA; Domain associated with PX domains
    7. NM_001350870.1NP_001337799.1  sorting nexin-13 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC073205, AC080080
      Consensus CDS
      CCDS87483.1
      Related
      ENSP00000386639.1, ENST00000409604.1
      Conserved Domains (1) summary
      cl02564
      Location:97149
      PXA; PXA domain
    8. NM_015132.4NP_055947.1  sorting nexin-13 isoform b

      See identical proteins and their annotated locations for NP_055947.1

      Status: REVIEWED

      Source sequence(s)
      AC073205, AF420470, BC045667, DB050735
      Consensus CDS
      CCDS47551.1
      UniProtKB/Swiss-Prot
      Q9Y5W8
      UniProtKB/TrEMBL
      A0A024R9Z9, Q86XC4
      Related
      ENSP00000398789.2, OTTHUMP00000202283, ENST00000428135.7, OTTHUMT00000327607
      Conserved Domains (4) summary
      cd06873
      Location:557676
      PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
      cd08719
      Location:377511
      RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
      smart00313
      Location:97284
      PXA; Domain associated with PX domains
      pfam08628
      Location:792900
      Nexin_C; Sorting nexin C terminal

    RNA

    1. NR_146932.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073205, AC080080
    2. NR_146933.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073205, AC080080

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

      Range
      17790761..17940508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011893.2XP_016867382.1  sorting nexin-13 isoform X2

    2. XM_011515229.2XP_011513531.1  sorting nexin-13 isoform X1

      Conserved Domains (4) summary
      cd06873
      Location:557687
      PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
      cd08719
      Location:377511
      RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
      smart00313
      Location:97284
      PXA; Domain associated with PX domains
      pfam08628
      Location:749857
      Nexin_C; Sorting nexin C terminal
    3. XM_011515233.3XP_011513535.1  sorting nexin-13 isoform X4

      Conserved Domains (4) summary
      cd06873
      Location:455585
      PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
      cd08719
      Location:275409
      RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
      pfam08628
      Location:701809
      Nexin_C; Sorting nexin C terminal
      cl02564
      Location:45182
      PXA; PXA domain
    4. XM_017011896.2XP_016867385.1  sorting nexin-13 isoform X5

      Conserved Domains (4) summary
      cd06873
      Location:428558
      PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
      cd08719
      Location:248382
      RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
      pfam08628
      Location:674782
      Nexin_C; Sorting nexin C terminal
      cl02564
      Location:18155
      PXA; PXA domain
    5. XM_011515231.2XP_011513533.1  sorting nexin-13 isoform X3

      See identical proteins and their annotated locations for XP_011513533.1

      Conserved Domains (4) summary
      cd06873
      Location:477607
      PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
      cd08719
      Location:297431
      RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
      smart00313
      Location:17204
      PXA; Domain associated with PX domains
      pfam08628
      Location:723831
      Nexin_C; Sorting nexin C terminal
    6. XM_011515230.2XP_011513532.1  sorting nexin-13 isoform X3

      See identical proteins and their annotated locations for XP_011513532.1

      Conserved Domains (4) summary
      cd06873
      Location:477607
      PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
      cd08719
      Location:297431
      RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
      smart00313
      Location:17204
      PXA; Domain associated with PX domains
      pfam08628
      Location:723831
      Nexin_C; Sorting nexin C terminal
    7. XM_024446696.1XP_024302464.1  sorting nexin-13 isoform X5

      Conserved Domains (4) summary
      cd06873
      Location:428558
      PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
      cd08719
      Location:248382
      RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
      pfam08628
      Location:674782
      Nexin_C; Sorting nexin C terminal
      cl02564
      Location:18155
      PXA; PXA domain
    8. XM_017011894.2XP_016867383.1  sorting nexin-13 isoform X3

      Conserved Domains (4) summary
      cd06873
      Location:477607
      PX_SNX13; The phosphoinositide binding Phox Homology domain of Sorting Nexin 13
      cd08719
      Location:297431
      RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
      smart00313
      Location:17204
      PXA; Domain associated with PX domains
      pfam08628
      Location:723831
      Nexin_C; Sorting nexin C terminal
    9. XM_005249673.5XP_005249730.1  sorting nexin-13 isoform X6

      Conserved Domains (2) summary
      cd08719
      Location:377511
      RGS_SNX13; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein
      smart00313
      Location:97284
      PXA; Domain associated with PX domains
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