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    FLNA filamin A [ Homo sapiens (human) ]

    Gene ID: 2316, updated on 18-Nov-2018

    Summary

    Official Symbol
    FLNAprovided by HGNC
    Official Full Name
    filamin Aprovided by HGNC
    Primary source
    HGNC:HGNC:3754
    See related
    Ensembl:ENSG00000196924 MIM:300017; Vega:OTTHUMG00000022712
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLN; FMD; MNS; OPD; ABPX; CSBS; CVD1; FGS2; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280
    Summary
    The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
    Expression
    Broad expression in endometrium (RPKM 345.6), esophagus (RPKM 285.0) and 22 other tissues See more
    Orthologs

    Genomic context

    See FLNA in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (154348532..154374638, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153576900..153603006, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene transketolase like 1 Neighboring gene uncharacterized LOC105373386 Neighboring gene Xq28 proximal FLNA-EMD recombination region Neighboring gene Xq28 distal FLNA-EMD recombination region Neighboring gene emerin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Cardiac valvular dysplasia, X-linked
    MedGen: C0262436 OMIM: 314400 GeneReviews: Not available
    Compare labs
    FG syndrome 2
    MedGen: C1845902 OMIM: 300321 GeneReviews: Not available
    Compare labs
    Frontometaphyseal dysplasia Compare labs
    Intestinal pseudoobstruction neuronal chronic idiopathic X-linked
    MedGen: C2746068 OMIM: 300048 GeneReviews: Not available
    Compare labs
    Melnick-Needles syndrome Compare labs
    Oto-palato-digital syndrome, type I Compare labs
    Oto-palato-digital syndrome, type II Compare labs
    Periventricular nodular heterotopia 1 Compare labs
    Terminal osseous dysplasia
    MedGen: C1846129 OMIM: 300244 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated (2012-04-26)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated (2012-04-26)

    ClinGen Genome Curation PagePubMed

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify filamin A (FLNA), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    env Filamin-A-dependent activation of the RhoA-ROCK-LIMK-cofilin pathway is a major event in HIV-1 gp120-induced receptor clustering PubMed
    env HIV-1 gp120 promotes filamin binding to both CD4 and CXCR4 PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify filamin A (FLNA), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify filamin A (FLNA), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Cellular biotinylated filamin A, alpha (FLNA) protein is incorporated into HIV-1 Gag virus-like particles PubMed
    gag Tandem affinity purification and mass spectrometry analysis identify filamin A (FLNA), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    gag HIV-1 Gag binds to filamin A through the CA domain, which leads to facilitate Gag trafficking to the plasma membrane PubMed
    gag HIV-1 Gag co-localizes with filamin A in mammalian cells. Depletion of filamin A inhibits HIV-1 particle release and induces Gag accumulation at the LE/MVB compartment PubMed
    Tat tat Filamin A, alpha (FLNA) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
    tat Expression of HIV-1 Tat upregulates the abundance of filamin A, alpha (FLNA) in the nucleoli of Jurkat T-cells PubMed
    Vpr vpr HIV-1 Vpr upregulates FLNA in HeLa cells within 12 hours of exposure PubMed
    retropepsin gag-pol A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
    • Cell junction organization, organism-specific biosystem (from REACTOME)
      Cell junction organization, organism-specific biosystem
      Cell junction organization
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
    • Cell-extracellular matrix interactions, organism-specific biosystem (from REACTOME)
      Cell-extracellular matrix interactions, organism-specific biosystemCell-extracellular matrix (ECM) interactions play a critical role in regulating a variety of cellular processes in multicellular organisms including motility, shape change, survival, proliferation an...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • GP1b-IX-V activation signalling, organism-specific biosystem (from REACTOME)
      GP1b-IX-V activation signalling, organism-specific biosystemThe platelet GPIb complex (GP1b-IX-V) together with GPVI are primarily responsible for regulating the initial adhesion of platelets to the damaged blood vessel and platelet activation. The importance...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Hypothesized Pathways in Pathogenesis of Cardiovascular Disease, organism-specific biosystem (from WikiPathways)
      Hypothesized Pathways in Pathogenesis of Cardiovascular Disease, organism-specific biosystemThe pathways hypothesized to be involved in cardiovascular diseases begin with LTBPs and Fibrillins activating a TGFBR complex. The complex can begin the canonical TGFB pathway involving SMAD protei...
    • IL-4 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-4 Signaling Pathway, organism-specific biosystemIL-4 is a glycoprotein which is composed of 129 amino acids and has a molecular weight of 20kDa. IL-4 and IL-13 are produced by CD4+ cells and exhibit significant functional overlap. Both these cytok...
    • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Noncanonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Noncanonical Wnt signaling pathway, organism-specific biosystem
      Noncanonical Wnt signaling pathway
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Platelet degranulation, organism-specific biosystem (from REACTOME)
      Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
    • Prolactin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Prolactin Signaling Pathway, organism-specific biosystemProlactin (PRL), a pleiotropic polypeptide hormone, mostly secreted by the lactotrophic cells of anterior pituitary gland and to a lesser extent expressed in numerous extra pituitary tissues such as ...
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases activate PAKs, organism-specific biosystem (from REACTOME)
      RHO GTPases activate PAKs, organism-specific biosystemThe PAKs (p21-activated kinases) are a family of serine/threonine kinases mainly implicated in cytoskeletal rearrangements. All PAKs share a conserved catalytic domain located at the carboxyl terminu...
    • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
      Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Salmonella infection, conserved biosystem (from KEGG)
      Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD4+ T cells, organism-specific biosystem
      TCR signaling in naive CD4+ T cells

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ43642, DKFZp434P031

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Fc-gamma receptor I complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G protein-coupled receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA binding HDA PubMed 
    Rac GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Ral GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rho GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SMAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cadherin binding HDA PubMed 
    ion channel binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    mu-type opioid receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    small GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin crosslink formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin cytoskeleton reorganization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase-inhibiting dopamine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell junction assembly TAS
    Traceable Author Statement
    more info
     
    cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoplasmic sequestering of protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to virus TAS
    Traceable Author Statement
    more info
     
    establishment of Sertoli cell barrier IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    formation of radial glial scaffolds IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic spindle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase I IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet activation TAS
    Traceable Author Statement
    more info
     
    platelet aggregation HMP PubMed 
    platelet degranulation TAS
    Traceable Author Statement
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
    positive regulation of actin filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neural precursor cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization to cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    receptor clustering IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of membrane repolarization during atrial cardiac muscle cell action potential IC
    Inferred by Curator
    more info
     
    regulation of membrane repolarization during cardiac muscle cell action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    semaphorin-plexin signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    wound healing, spreading of cells IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Myb complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Z disc ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    actin cytoskeleton IC
    Inferred by Curator
    more info
    PubMed 
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    apical dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cortical cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome HDA PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    colocalizes_with filamentous actin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion HDA PubMed 
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    membrane HDA PubMed 
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    filamin-A
    Names
    actin binding protein 280
    alpha-filamin
    endothelial actin-binding protein
    epididymis secretory sperm binding protein
    filamin A, alpha
    filamin-1
    non-muscle filamin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011506.1 RefSeqGene

      Range
      5001..31107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001110556.1NP_001104026.1  filamin-A isoform 2

      See identical proteins and their annotated locations for NP_001104026.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate in-frame exon and encodes a slightly longer protein isoform (2).
      Source sequence(s)
      AB191260, BC067111, BP235228, X53416
      Consensus CDS
      CCDS48194.1
      UniProtKB/Swiss-Prot
      P21333
      UniProtKB/TrEMBL
      Q60FE5, Q6NXF2
      Related
      ENSP00000358866.3, OTTHUMP00000024321, ENST00000369850.8, OTTHUMT00000058942
      Conserved Domains (4) summary
      smart00033
      Location:172264
      CH; Calponin homology domain
      smart00557
      Location:14481542
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00014
      Location:44148
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00630
      Location:14451536
      Filamin; Filamin/ABP280 repeat
    2. NM_001456.3NP_001447.2  filamin-A isoform 1

      See identical proteins and their annotated locations for NP_001447.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the predominant transcript and encodes a slightly shorter protein isoform (1).
      Source sequence(s)
      AB191260, BC067111, BP235228, X53416
      Consensus CDS
      CCDS44021.1
      UniProtKB/Swiss-Prot
      P21333
      UniProtKB/TrEMBL
      Q60FE5, Q6NXF2
      Related
      ENSP00000416926.1, ENST00000422373.5
      Conserved Domains (4) summary
      smart00033
      Location:172264
      CH; Calponin homology domain
      smart00557
      Location:14481542
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00014
      Location:44148
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00630
      Location:14451536
      Filamin; Filamin/ABP280 repeat

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

      Range
      154348532..154374638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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