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    PPRC1 PPARG related coactivator 1 [ Homo sapiens (human) ]

    Gene ID: 23082, updated on 7-Jul-2019

    Summary

    Official Symbol
    PPRC1provided by HGNC
    Official Full Name
    PPARG related coactivator 1provided by HGNC
    Primary source
    HGNC:HGNC:30025
    See related
    Ensembl:ENSG00000148840 MIM:617462
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRC
    Summary
    The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
    Expression
    Ubiquitous expression in gall bladder (RPKM 7.9), appendix (RPKM 7.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See PPRC1 in Genome Data Viewer
    Location:
    10q24.32
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (102120634..102150333)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103892787..103910090)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene HPS6 biogenesis of lysosomal organelles complex 2 subunit 3 Neighboring gene LIM domain binding 1 Neighboring gene nucleolar and coiled-body phosphoprotein 1 Neighboring gene ELOVL fatty acid elongase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Mitochondrial Gene Expression, organism-specific biosystem (from WikiPathways)
      Mitochondrial Gene Expression, organism-specific biosystemNumerous nuclear-encoded genes co-ordinate the expression of genes encoded on the mitochondrial genome.
    • Mitochondrial biogenesis, organism-specific biosystem (from REACTOME)
      Mitochondrial biogenesis, organism-specific biosystemMitochondrial biogenesis and remodeling occur in response to exercise and redox state (reviewed in Scarpulla et al. 2012, Handy and Loscalzo 2012, Piantadosi and Suliman 2012, Scarpulla 2011, Wenz et...
    • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
      Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
    • Transcriptional activation of mitochondrial biogenesis, organism-specific biosystem (from REACTOME)
      Transcriptional activation of mitochondrial biogenesis, organism-specific biosystemPhosphorylated PPARGC1A (PGC-1alpha) does not bind DNA directly but instead interacts with other transcription factors, notably NRF1 and NRF2 (via HCF1). NRF1 and NRF2 together with PPARGC1A activate...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0595, MGC74642, RP11-302K17.6

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    nuclear receptor transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    mitochondrion organization TAS
    Traceable Author Statement
    more info
     
    positive regulation of DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    peroxisome proliferator-activated receptor gamma coactivator-related protein 1
    Names
    PGC-1-related coactivator
    peroxisome proliferator-activated receptor gamma, coactivator-related 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047132.1 RefSeqGene

      Range
      5001..22340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001288727.1NP_001275656.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two exons in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AB011167, AL500527, BU742486, HY023373
      Consensus CDS
      CCDS73186.1
      UniProtKB/Swiss-Prot
      Q5VV67
      UniProtKB/TrEMBL
      E7EVG6
      Related
      ENSP00000399743.2, ENST00000413464.6
      Conserved Domains (1) summary
      cd12624
      Location:12771367
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
    2. NM_001288728.2NP_001275657.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001275657.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region and initiates translation at an alternate start codon, which leads to a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB011167, AF325193, BC063806, BU742486, HY023373
      UniProtKB/Swiss-Prot
      Q5VV67
      Conserved Domains (1) summary
      cd12624
      Location:14191509
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
    3. NM_015062.5NP_055877.3  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 1

      See identical proteins and their annotated locations for NP_055877.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB011167, BU742486, HY023373
      Consensus CDS
      CCDS7529.1
      UniProtKB/Swiss-Prot
      Q5VV67
      Related
      ENSP00000278070.2, ENST00000278070.7
      Conserved Domains (1) summary
      cd12624
      Location:15411631
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      102120634..102150333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447914.1XP_024303682.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6

      Conserved Domains (2) summary
      cd12624
      Location:14621552
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
      cl26464
      Location:5311123
      Atrophin-1; Atrophin-1 family
    2. XM_024447917.1XP_024303685.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6

      Conserved Domains (2) summary
      cd12624
      Location:14621552
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
      cl26464
      Location:5311123
      Atrophin-1; Atrophin-1 family
    3. XM_011539551.2XP_011537853.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

      Conserved Domains (1) summary
      cd12624
      Location:14581548
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
    4. XM_017015982.1XP_016871471.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X1

    5. XM_017015984.1XP_016871473.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X8

    6. XM_011539549.2XP_011537851.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X3

      Conserved Domains (1) summary
      cd12624
      Location:14981588
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
    7. XM_005269656.3XP_005269713.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X2

      Conserved Domains (1) summary
      cd12624
      Location:15231613
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
    8. XM_011539552.2XP_011537854.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X9

      Conserved Domains (1) summary
      cd12624
      Location:12591349
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
    9. XM_017015985.1XP_016871474.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X10

    10. XM_017015983.1XP_016871472.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X5

    11. XM_006717731.3XP_006717794.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X11

      Conserved Domains (1) summary
      PHA03247
      Location:6101136
      PHA03247; large tegument protein UL36; Provisional
    12. XM_024447913.1XP_024303681.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X4

      Conserved Domains (2) summary
      cd12624
      Location:14921582
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
      cl26464
      Location:5611153
      Atrophin-1; Atrophin-1 family
    13. XM_024447915.1XP_024303683.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6

      Conserved Domains (2) summary
      cd12624
      Location:14621552
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
      cl26464
      Location:5311123
      Atrophin-1; Atrophin-1 family
    14. XM_024447916.1XP_024303684.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6

      Conserved Domains (2) summary
      cd12624
      Location:14621552
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
      cl26464
      Location:5311123
      Atrophin-1; Atrophin-1 family

    RNA

    1. XR_001747067.1 RNA Sequence

    2. XR_001747068.1 RNA Sequence

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