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    FNDC3A fibronectin type III domain containing 3A [ Homo sapiens (human) ]

    Gene ID: 22862, updated on 13-Feb-2019

    Summary

    Official Symbol
    FNDC3Aprovided by HGNC
    Official Full Name
    fibronectin type III domain containing 3Aprovided by HGNC
    Primary source
    HGNC:HGNC:20296
    See related
    Ensembl:ENSG00000102531 MIM:615794
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HUGO; FNDC3; bA203I16.1; bA203I16.5
    Expression
    Ubiquitous expression in thyroid (RPKM 26.8), adrenal (RPKM 18.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See FNDC3A in Genome Data Viewer
    Location:
    13q14.2
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (48975241..49209779)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (49550048..49783915)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene proteasome activator subunit 2 pseudogene 2 Neighboring gene uncharacterized LOC107984559 Neighboring gene RNA, U6 small nuclear 60, pseudogene Neighboring gene RAD17 pseudogene 2 Neighboring gene RNY3 pseudogene 2 Neighboring gene cytochrome c oxidase subunit 7C pseudogene 1 Neighboring gene 2-oxoglutarate and iron dependent oxygenase domain containing 1 pseudogene 1 Neighboring gene motilin receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ31509, KIAA0970

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    Process Evidence Code Pubs
    Sertoli cell development IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    spermatid development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane HDA PubMed 
    vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    fibronectin type-III domain-containing protein 3A
    Names
    human gene expressed in odontoblasts

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079673.2NP_001073141.1  fibronectin type-III domain-containing protein 3A isoform 1

      See identical proteins and their annotated locations for NP_001073141.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AJ749706, AL137000, BM973827
      Consensus CDS
      CCDS41886.1
      UniProtKB/Swiss-Prot
      Q9Y2H6
      UniProtKB/TrEMBL
      A0A024RDT9
      Related
      ENSP00000417257.1, ENST00000492622.6
      Conserved Domains (1) summary
      cd00063
      Location:371462
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. NM_001278438.1NP_001265367.1  fibronectin type-III domain-containing protein 3A isoform 1

      See identical proteins and their annotated locations for NP_001265367.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR exon, compared to variant 1. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      BC060816, BC132812, BM973827, DB460317
      Consensus CDS
      CCDS41886.1
      UniProtKB/Swiss-Prot
      Q9Y2H6
      UniProtKB/TrEMBL
      A0A024RDT9
      Related
      ENSP00000441831.1, ENST00000541916.5
      Conserved Domains (1) summary
      cd00063
      Location:371462
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    3. NM_014923.4NP_055738.3  fibronectin type-III domain-containing protein 3A isoform 2

      See identical proteins and their annotated locations for NP_055738.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AJ749707, AK302415, BC051029, BM973827
      Consensus CDS
      CCDS9413.2
      UniProtKB/Swiss-Prot
      Q9Y2H6
      UniProtKB/TrEMBL
      A0A024RDV5
      Related
      ENSP00000381362.3, ENST00000398316.7
      Conserved Domains (1) summary
      cd00063
      Location:315406
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RNA

    1. NR_103528.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate 5' exon and an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC051029, BM973827, DB460317
      Related
      ENST00000484074.5

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

      Range
      48975241..49209779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020440.2XP_016875929.1  fibronectin type-III domain-containing protein 3A isoform X1

      UniProtKB/Swiss-Prot
      Q9Y2H6
      UniProtKB/TrEMBL
      A0A024RDT9
      Conserved Domains (1) summary
      cd00063
      Location:371462
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. XM_017020442.2XP_016875931.1  fibronectin type-III domain-containing protein 3A isoform X2

      UniProtKB/Swiss-Prot
      Q9Y2H6
      Conserved Domains (1) summary
      cd00063
      Location:307398
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    3. XM_017020443.1XP_016875932.1  fibronectin type-III domain-containing protein 3A isoform X3

      Conserved Domains (1) summary
      cd00063
      Location:371462
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    4. XM_017020441.2XP_016875930.1  fibronectin type-III domain-containing protein 3A isoform X2

      UniProtKB/Swiss-Prot
      Q9Y2H6
      Conserved Domains (1) summary
      cd00063
      Location:307398
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    5. XM_011534997.3XP_011533299.1  fibronectin type-III domain-containing protein 3A isoform X2

      See identical proteins and their annotated locations for XP_011533299.1

      UniProtKB/Swiss-Prot
      Q9Y2H6
      Conserved Domains (1) summary
      cd00063
      Location:307398
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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