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Trp53 transformation related protein 53 [ Mus musculus (house mouse) ]

Gene ID: 22059, updated on 23-Feb-2021

Summary

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Official Symbol: Trp53provided by MGI
Official Full Name: transformation related protein 53provided by MGI
Primary source: MGI:MGI:98834
See related: Ensembl:ENSMUSG00000059552
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p4; p5; bbl; bfy; bhy; p44; p53; Tp53
Summary: This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in thymus adult (RPKM 69.1), ovary adult (RPKM 56.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

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See Trp53 in Genome Data Viewer

Location:: 11 B3; 11 42.83 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69471174..69482699)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69580348..69591873)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	11	NC_000077.5 (69393861..69405375)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3.
Title: The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3.
Mouse bone marrow mesenchymal stem cells with distinct p53 statuses display differential characteristics.
Title: Mouse bone marrow mesenchymal stem cells with distinct p53 statuses display differential characteristics.
Age-related dysfunction of p53-regulated phagocytic activity in macrophages.
Title: Age-related dysfunction of p53-regulated phagocytic activity in macrophages.
p53/microRNA-214/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease.
Title: p53/microRNA-214/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease.
Overexpression of p53 due to excess protein O-GlcNAcylation is associated with coronary microvascular disease in type 2 diabetes.
Title: Overexpression of p53 due to excess protein O-GlcNAcylation is associated with coronary microvascular disease in type 2 diabetes.
Critical Role for P53 in Regulating the Cell Cycle of Ground State Embryonic Stem Cells.
Title: Critical Role for P53 in Regulating the Cell Cycle of Ground State Embryonic Stem Cells.
Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling.
Title: Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling.
Involvement of p53 in the Responses of Cardiac Muscle Cells to Heat Shock Exposure and Heat Acclimation.
Title: Involvement of p53 in the Responses of Cardiac Muscle Cells to Heat Shock Exposure and Heat Acclimation.
Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo.
Title: Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo.
Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction.
Title: <i>Kdm6a</i> Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with <i>p53</i> Dysfunction.

Submit: New GeneRIF Correction See all GeneRIFs (1731)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (87) 1 citation
Chemically induced (ENU) (2)
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC61147P1 (e-PCR)
- UniSTS:273411

PMC138156P1 (e-PCR)
- UniSTS:270862

PMC340938P3 (e-PCR)
- UniSTS:273171

PMC138798P1 (e-PCR)
- UniSTS:270872

Trp53 (e-PCR), detects polymorphism
- UniSTS:144670

Trp53 (e-PCR), detects polymorphism
- UniSTS:144671

Trp53 (e-PCR), detects polymorphism
- UniSTS:144672

Trp53 (e-PCR), detects polymorphism
- UniSTS:144673

PMC122453P1 (e-PCR)
- UniSTS:270390

D11Mit107 (e-PCR), detects polymorphism
- UniSTS:126294

D11Mit107.1 (e-PCR), detects polymorphism
- UniSTS:126295

PMC240708P1 (e-PCR)
- UniSTS:272219

PMC316543P1 (e-PCR)
- UniSTS:273004

Trp53 (e-PCR), detects polymorphism
- UniSTS:531072

PMC316663P4 (e-PCR)
- UniSTS:273032

PMC316663P5 (e-PCR)
- UniSTS:273033

PMC316663P6 (e-PCR)
- UniSTS:273034

PMC193696P1 (e-PCR)
- UniSTS:271755

PMC316663P7 (e-PCR)
- UniSTS:273035

Trp53 (e-PCR), detects polymorphism
- UniSTS:461981

PMC305262P1 (e-PCR)
- UniSTS:272541

PMC316856P2 (e-PCR)
- UniSTS:273054

X00876 (e-PCR)
- UniSTS:160672

Trp53 (e-PCR), detects polymorphism
- UniSTS:496813

PMC165710P1 (e-PCR)
- UniSTS:271545

D11Mit107.2 (e-PCR), detects polymorphism
- UniSTS:141761

PMC55531P2 (e-PCR)
- UniSTS:273346

Trp53 (e-PCR), detects polymorphism
- UniSTS:527588

Trp53 (e-PCR), detects polymorphism
- UniSTS:548087

PMC310707P1 (e-PCR)
- UniSTS:272632

Homology

Homologs of the Trp53 gene: The Trp53 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 260 organisms have orthologs with human gene Trp53
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	ISO Inferred from Sequence Orthology more info
DNA binding	ISO Inferred from Sequence Orthology more info
DNA-binding transcription activator activity	ISO Inferred from Sequence Orthology more info
DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
DNA-binding transcription activator activity, RNA polymerase II-specific	IGI Inferred from Genetic Interaction more info	PubMed
DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
MDM2/MDM4 family protein binding	IPI Inferred from Physical Interaction more info	PubMed
MDM2/MDM4 family protein binding	ISO Inferred from Sequence Orthology more info
RNA polymerase II activating transcription factor binding	ISO Inferred from Sequence Orthology more info
RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
RNA polymerase II transcription factor binding	ISO Inferred from Sequence Orthology more info
RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
TFIID-class transcription factor complex binding	ISO Inferred from Sequence Orthology more info
chaperone binding	ISO Inferred from Sequence Orthology more info
chromatin binding	IDA Inferred from Direct Assay more info	PubMed
chromatin binding	ISO Inferred from Sequence Orthology more info
cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
copper ion binding	ISO Inferred from Sequence Orthology more info
core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enzyme binding	ISO Inferred from Sequence Orthology more info
histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
histone deacetylase binding	ISO Inferred from Sequence Orthology more info
histone deacetylase regulator activity	IDA Inferred from Direct Assay more info	PubMed
identical protein binding	ISO Inferred from Sequence Orthology more info
mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
metal ion binding	IEA Inferred from Electronic Annotation more info
p53 binding	ISO Inferred from Sequence Orthology more info
promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
protease binding	ISO Inferred from Sequence Orthology more info
protein C-terminus binding	ISO Inferred from Sequence Orthology more info
protein N-terminus binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
protein kinase binding	ISO Inferred from Sequence Orthology more info
protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
protein phosphatase binding	ISO Inferred from Sequence Orthology more info
protein self-association	ISO Inferred from Sequence Orthology more info
receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
transcription coregulator binding	ISO Inferred from Sequence Orthology more info
transcription factor binding	ISO Inferred from Sequence Orthology more info
transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
B cell lineage commitment	IMP Inferred from Mutant Phenotype more info	PubMed
DNA damage response, signal transduction by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
DNA damage response, signal transduction by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IGI Inferred from Genetic Interaction more info	PubMed
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	ISO Inferred from Sequence Orthology more info
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IDA Inferred from Direct Assay more info	PubMed
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ISO Inferred from Sequence Orthology more info
DNA strand renaturation	ISO Inferred from Sequence Orthology more info
ER overload response	ISO Inferred from Sequence Orthology more info
T cell differentiation in thymus	IGI Inferred from Genetic Interaction more info	PubMed
T cell lineage commitment	IMP Inferred from Mutant Phenotype more info	PubMed
T cell proliferation involved in immune response	IGI Inferred from Genetic Interaction more info	PubMed
apoptotic process	IDA Inferred from Direct Assay more info	PubMed
apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
autophagy	ISO Inferred from Sequence Orthology more info
bone marrow development	ISO Inferred from Sequence Orthology more info
cardiac septum morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
cell aging	IGI Inferred from Genetic Interaction more info	PubMed
cell aging	ISO Inferred from Sequence Orthology more info
cell cycle	IEA Inferred from Electronic Annotation more info
cell cycle arrest	ISO Inferred from Sequence Orthology more info
cellular protein localization	ISO Inferred from Sequence Orthology more info
cellular response to DNA damage stimulus	IDA Inferred from Direct Assay more info	PubMed
cellular response to DNA damage stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to DNA damage stimulus	ISO Inferred from Sequence Orthology more info
cellular response to UV	IDA Inferred from Direct Assay more info	PubMed
cellular response to UV	IGI Inferred from Genetic Interaction more info	PubMed
cellular response to UV	ISO Inferred from Sequence Orthology more info
cellular response to UV-C	IGI Inferred from Genetic Interaction more info	PubMed
cellular response to actinomycin D	ISO Inferred from Sequence Orthology more info
cellular response to gamma radiation	IDA Inferred from Direct Assay more info	PubMed
cellular response to gamma radiation	ISO Inferred from Sequence Orthology more info
cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
cellular response to ionizing radiation	IDA Inferred from Direct Assay more info	PubMed
cellular response to ionizing radiation	IGI Inferred from Genetic Interaction more info	PubMed
cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
cellular response to stress	IGI Inferred from Genetic Interaction more info	PubMed
central nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
cerebellum development	IDA Inferred from Direct Assay more info	PubMed
chromatin assembly	ISO Inferred from Sequence Orthology more info
chromosome organization	IGI Inferred from Genetic Interaction more info	PubMed
circadian behavior	IMP Inferred from Mutant Phenotype more info	PubMed
circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
embryonic organ development	IGI Inferred from Genetic Interaction more info	PubMed
entrainment of circadian clock by photoperiod	IMP Inferred from Mutant Phenotype more info	PubMed
gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
heart development	IGI Inferred from Genetic Interaction more info	PubMed
hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
hematopoietic stem cell differentiation	ISO Inferred from Sequence Orthology more info
in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
NOT in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
interferon-gamma-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
intrinsic apoptotic signaling pathway by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
intrinsic apoptotic signaling pathway by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info	PubMed
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
intrinsic apoptotic signaling pathway in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
mRNA transcription	ISO Inferred from Sequence Orthology more info
mitochondrial DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
mitotic G1 DNA damage checkpoint	IMP Inferred from Mutant Phenotype more info	PubMed
mitotic G1 DNA damage checkpoint	ISO Inferred from Sequence Orthology more info
mitotic cell cycle arrest	IDA Inferred from Direct Assay more info	PubMed
multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
negative regulation of DNA replication	IDA Inferred from Direct Assay more info	PubMed
negative regulation of DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of glucose catabolic process to lactate via pyruvate	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of pentose-phosphate shunt	ISO Inferred from Sequence Orthology more info
negative regulation of production of miRNAs involved in gene silencing by miRNA	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of telomerase activity	ISO Inferred from Sequence Orthology more info
negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
negative regulation of transcription, DNA-templated	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription, DNA-templated	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transcription, DNA-templated	ISO Inferred from Sequence Orthology more info
negative regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
nucleotide-excision repair	ISO Inferred from Sequence Orthology more info
oligodendrocyte apoptotic process	ISO Inferred from Sequence Orthology more info
oxidative stress-induced premature senescence	ISO Inferred from Sequence Orthology more info
positive regulation of RNA polymerase II transcription preinitiation complex assembly	ISO Inferred from Sequence Orthology more info
positive regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
positive regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell aging	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
positive regulation of cell cycle arrest	ISO Inferred from Sequence Orthology more info
positive regulation of execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
positive regulation of histone deacetylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of leukocyte migration	ISO Inferred from Sequence Orthology more info
positive regulation of mitochondrial membrane permeability	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of pri-miRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
positive regulation of production of miRNAs involved in gene silencing by miRNA	ISO Inferred from Sequence Orthology more info
positive regulation of programmed necrotic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
positive regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
positive regulation of thymocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter in response to stress	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter in response to stress	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter in response to stress	ISS Inferred from Sequence or Structural Similarity more info	PubMed
positive regulation of transcription, DNA-templated	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-templated	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of transcription, DNA-templated	ISO Inferred from Sequence Orthology more info
programmed cell death	IEA Inferred from Electronic Annotation more info
protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
protein localization	ISO Inferred from Sequence Orthology more info
protein stabilization	IGI Inferred from Genetic Interaction more info	PubMed
protein tetramerization	IEA Inferred from Electronic Annotation more info
protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
rRNA transcription	IGI Inferred from Genetic Interaction more info	PubMed
regulation of DNA damage response, signal transduction by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
regulation of cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cellular senescence	IGI Inferred from Genetic Interaction more info	PubMed
regulation of fibroblast apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
regulation of hydrogen peroxide-induced cell death	ISO Inferred from Sequence Orthology more info
regulation of intracellular pH	ISO Inferred from Sequence Orthology more info
regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of mitochondrial membrane permeability involved in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
regulation of thymocyte apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
regulation of tissue remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription from RNA polymerase II promoter in response to DNA damage	ISO Inferred from Sequence Orthology more info
regulation of transcription from RNA polymerase II promoter in response to DNA damage	ISS Inferred from Sequence or Structural Similarity more info	PubMed
regulation of transcription, DNA-templated	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-templated	ISO Inferred from Sequence Orthology more info
release of cytochrome c from mitochondria	IDA Inferred from Direct Assay more info	PubMed
release of cytochrome c from mitochondria	IGI Inferred from Genetic Interaction more info	PubMed
replicative senescence	ISO Inferred from Sequence Orthology more info
response to UV	IDA Inferred from Direct Assay more info	PubMed
response to UV	IMP Inferred from Mutant Phenotype more info	PubMed
response to X-ray	IDA Inferred from Direct Assay more info	PubMed
response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed
response to drug	IDA Inferred from Direct Assay more info	PubMed
response to gamma radiation	IDA Inferred from Direct Assay more info	PubMed
response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
response to gamma radiation	ISO Inferred from Sequence Orthology more info
response to ischemia	IMP Inferred from Mutant Phenotype more info	PubMed
response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
response to salt stress	IGI Inferred from Genetic Interaction more info	PubMed
rhythmic process	IEA Inferred from Electronic Annotation more info
signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
viral process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
PML body	ISO Inferred from Sequence Orthology more info
RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
centrosome	ISO Inferred from Sequence Orthology more info
chromatin	ISO Inferred from Sequence Orthology more info
chromatin	ISS Inferred from Sequence or Structural Similarity more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	IDA Inferred from Direct Assay more info	PubMed
cytosol	ISO Inferred from Sequence Orthology more info	PubMed
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
colocalizes_with nuclear body	ISO Inferred from Sequence Orthology more info
nuclear matrix	ISO Inferred from Sequence Orthology more info
nucleolus	ISO Inferred from Sequence Orthology more info
nucleoplasm	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info	PubMed
protein-containing complex	ISO Inferred from Sequence Orthology more info
replication fork	IDA Inferred from Direct Assay more info	PubMed
site of double-strand break	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with transcription factor TFIID complex	ISO Inferred from Sequence Orthology more info
transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cellular tumor antigen p53

Names: ME-delta123p53; mutant p53; p53 cellular tumor antigen; tumor suppressor p53; tumor supressor p53

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127233.1 → NP_001120705.1 cellular tumor antigen p53 isoform b

See identical proteins and their annotated locations for NP_001120705.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate splice site for the 3' exon, as compared to variant 1. The resulting isoform (b), also known p53AS, has a shorter and different C-terminus, as compared to isoform a.

Source sequence(s)

AI323249, AV450598, M13874, X01237

Consensus CDS

CCDS48826.1

UniProtKB/Swiss-Prot

P02340

UniProtKB/TrEMBL

Q80ZA1

Related

ENSMUSP00000127130.1, ENSMUST00000171247.7

Conserved Domains (3) summary

cd08367
Location:106 → 286

P53; P53 DNA-binding domain

pfam07710
Location:316 → 352

P53_tetramer; P53 tetramerisation motif

pfam08563
Location:9 → 31

P53_TAD; P53 transactivation motif
NM_011640.3 → NP_035770.2 cellular tumor antigen p53 isoform a

See identical proteins and their annotated locations for NP_035770.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AB221571, AI323249, AK147815, AV450598, X01237

Consensus CDS

CCDS36193.1

UniProtKB/Swiss-Prot

P02340

UniProtKB/TrEMBL

Q3UGQ1, Q549C9

Related

ENSMUSP00000104298.3, ENSMUST00000108658.9

Conserved Domains (3) summary

cd08367
Location:106 → 286

P53; P53 DNA-binding domain

pfam07710
Location:316 → 352

P53_tetramer; P53 tetramerisation motif

pfam08563
Location:9 → 31

P53_TAD; P53 transactivation motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

69471174..69482699

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245922.1 → XP_030101782.1 cellular tumor antigen p53 isoform X1

Conserved Domains (3) summary

cd08367
Location:106 → 286

P53; P53 DNA-binding domain

pfam07710
Location:316 → 352

P53_tetramer; P53 tetramerisation motif

pfam08563
Location:9 → 31

P53_TAD; P53 transactivation motif
XM_030245923.2 → XP_030101783.1 cellular tumor antigen p53 isoform X2

Conserved Domains (3) summary

cd08367
Location:106 → 286

P53; P53 DNA-binding domain

pfam07710
Location:316 → 352

P53_tetramer; P53 tetramerisation motif

pfam08563
Location:9 → 31

P53_TAD; P53 transactivation motif
XM_006533157.5 → XP_006533220.1 cellular tumor antigen p53 isoform X1

See identical proteins and their annotated locations for XP_006533220.1

UniProtKB/Swiss-Prot

P02340

UniProtKB/TrEMBL

Q549C9

Conserved Domains (3) summary

cd08367
Location:106 → 286

P53; P53 DNA-binding domain

pfam07710
Location:316 → 352

P53_tetramer; P53 tetramerisation motif

pfam08563
Location:9 → 31

P53_TAD; P53 transactivation motif