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    RNF152 ring finger protein 152 [ Homo sapiens (human) ]

    Gene ID: 220441, updated on 19-May-2026
    Official Symbol
    RNF152provided by HGNC
    Official Full Name
    ring finger protein 152provided by HGNC
    Primary source
    HGNC:HGNC:26811
    See related
    Ensembl:ENSG00000176641 MIM:616512; AllianceGenome:HGNC:26811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables small GTPase binding activity and ubiquitin protein ligase activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and protein ubiquitination. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]
    Expression
    Biased expression in kidney (RPKM 29.4), liver (RPKM 4.9) and 13 other tissues See more
    Orthologs
    all
    Try the new Gene page
    Try the new Transcripts and proteins table
    See RNF152 in Genome Data Viewer
    Location:
    18q21.33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (61808067..61894412, complement)
    RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (62011910..62098286, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (59475300..59560240, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904315 Neighboring gene long intergenic non-protein coding RNA 1544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:59483460-59484019 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9499 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9500 Neighboring gene uncharacterized LOC105372159 Neighboring gene uncharacterized LOC112268209 Neighboring gene Sharpr-MPRA regulatory region 15585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9501 Neighboring gene ribose 5-phosphate isomerase A pseudogene 1

    Go to nucleotide: Graphics FASTA GenBank

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Related articles in PubMed

    1. RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities. Zhang S, et al. Protein Cell, 2010 Jul. PMID 21203937, Free PMC Article
    2. Ring finger protein 152-dependent degradation of TSPAN12 suppresses hepatocellular carcinoma progression. Wan J, et al. Cancer Cell Int, 2021 Feb 18. PMID 33602225, Free PMC Article
    3. RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression. Zhu D, et al. Am J Pathol, 2023 Oct. PMID 37717980
    4. The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function. Okamoto T, et al. Int J Mol Sci, 2020 May 30. PMID 32486221, Free PMC Article
    5. A  conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation. Zhang W, et al. PLoS Biol, 2021 Jul. PMID 34297722, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression.
      Title: RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression.
    2. The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function.
      Title: The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function.
    3. A mechanism for regulation of mTORC1 signaling by RNF152-mediated K63-linked polyubiquitination of RagA.
      Title: The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation.
    4. RNF152 is a lysosome localized E3 ligase with pro-apoptotic activities
      Title: RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    Submit: New GeneRIF Correction

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ39176, MGC138161

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to amino acid starvation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K63-linked ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in organelle membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Preferred Names
    E3 ubiquitin-protein ligase RNF152
    Names
    RING-type E3 ubiquitin transferase RNF152
    NP_775828.1
    XP_005266707.1
    XP_005266709.1
    XP_011524180.1
    XP_011524181.1
    XP_016881101.1
    XP_047293305.1
    XP_054174259.1
    XP_054174260.1
    XP_054174261.1
    XP_054174262.1
    XP_054174263.1

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173557.3 → NP_775828.1  E3 ubiquitin-protein ligase RNF152

      See identical proteins and their annotated locations for NP_775828.1

      Status: VALIDATED

      Source sequence(s)
      AC105094, AK122758
      Consensus CDS
      CCDS11978.1
      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0
      Related
      ENSP00000316628.3, ENST00000312828.4
      Conserved Domains (1) summary
      cd16548
      Location:11 → 55
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      61808067..61894412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005266652.4 → XP_005266709.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      See identical proteins and their annotated locations for XP_005266709.1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0
      Related
      ENSP00000543329.1, ENST00000873270.1
      Conserved Domains (1) summary
      cd16548
      Location:11 → 55
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

    2. XM_017025612.2 → XP_016881101.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0
      Related
      ENSP00000543330.1, ENST00000873271.1
      Conserved Domains (1) summary
      cd16548
      Location:11 → 55
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

    3. XM_005266650.4 → XP_005266707.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      See identical proteins and their annotated locations for XP_005266707.1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0
      Related
      ENSP00000543327.1, ENST00000873268.1
      Conserved Domains (1) summary
      cd16548
      Location:11 → 55
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

    4. XM_011525878.3 → XP_011524180.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      See identical proteins and their annotated locations for XP_011524180.1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0
      Related
      ENSP00000543324.1, ENST00000873265.1
      Conserved Domains (1) summary
      cd16548
      Location:11 → 55
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

    5. XM_011525879.3 → XP_011524181.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      See identical proteins and their annotated locations for XP_011524181.1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0
      Related
      ENSP00000639199.1, ENST00000969140.1
      Conserved Domains (1) summary
      cd16548
      Location:11 → 55
      RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

    6. XM_047437349.1 → XP_047293305.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0
      Related
      ENSP00000639202.1, ENST00000969143.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      62011910..62098286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318284.1 → XP_054174259.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0

    2. XM_054318285.1 → XP_054174260.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0

    3. XM_054318286.1 → XP_054174261.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0

    4. XM_054318287.1 → XP_054174262.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0

    5. XM_054318288.1 → XP_054174263.1  E3 ubiquitin-protein ligase RNF152 isoform X1

      UniProtKB/Swiss-Prot
      B3KV99, Q52LA4, Q8N8N0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N8N0.1 GenPept UniProtKB/Swiss-Prot:Q8N8N0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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