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    LRRC63 leucine rich repeat containing 63 [ Homo sapiens (human) ]

    Gene ID: 220416, updated on 13-May-2022

    Summary

    Official Symbol
    LRRC63provided by HGNC
    Official Full Name
    leucine rich repeat containing 63provided by HGNC
    Primary source
    HGNC:HGNC:34296
    See related
    Ensembl:ENSG00000173988 AllianceGenome:HGNC:34296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 1.5), prostate (RPKM 0.2) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See LRRC63 in Genome Data Viewer
    Location:
    13q14.13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (46211928..46277115)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (45432940..45498131)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (46786063..46851250)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene lymphocyte cytosolic protein 1 Neighboring gene RNA, 7SL, cytoplasmic 288, pseudogene Neighboring gene uncharacterized LOC107984578 Neighboring gene uncharacterized LOC105370192 Neighboring gene small nucleolar RNA U13 Neighboring gene RN7SK pseudogene 5 Neighboring gene uncharacterized LOC105370194 Neighboring gene ABITRAM pseudogene 1 Neighboring gene uncharacterized LOC124903170 Neighboring gene long intergenic non-protein coding RNA 563

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • RP11-139H14.4

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 63

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282460.2NP_001269389.1  leucine-rich repeat-containing protein 63

      Status: VALIDATED

      Source sequence(s)
      AL137141, AL139801, BC030276
      Consensus CDS
      CCDS61325.1
      UniProtKB/Swiss-Prot
      Q05C16
      UniProtKB/TrEMBL
      J3KQU2
      Related
      ENSP00000469337.1, ENST00000595396.2
      Conserved Domains (2) summary
      sd00033
      Location:347369
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:393449
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      46211928..46277115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020422.2XP_016875911.1  leucine-rich repeat-containing protein 63 isoform X2

    2. XM_017020431.2XP_016875920.1  leucine-rich repeat-containing protein 63 isoform X8

    3. XM_047430137.1XP_047286093.1  leucine-rich repeat-containing protein 63 isoform X1

    4. XM_011534993.2XP_011533295.1  leucine-rich repeat-containing protein 63 isoform X6

    5. XM_047430140.1XP_047286096.1  leucine-rich repeat-containing protein 63 isoform X7

    6. XM_011534992.3XP_011533294.1  leucine-rich repeat-containing protein 63 isoform X5

      Related
      ENSP00000502820.1, ENST00000674837.1
    7. XM_011534989.3XP_011533291.1  leucine-rich repeat-containing protein 63 isoform X4

      Related
      ENSP00000501788.1, ENST00000676025.1
    8. XM_017020423.2XP_016875912.1  leucine-rich repeat-containing protein 63 isoform X3

    RNA

    1. XR_001749498.2 RNA Sequence

      Related
      ENST00000674570.1
    2. XR_007063660.1 RNA Sequence

    3. XR_941519.3 RNA Sequence

    4. XR_007063667.1 RNA Sequence

    5. XR_007063664.1 RNA Sequence

    6. XR_007063665.1 RNA Sequence

    7. XR_007063663.1 RNA Sequence

    8. XR_007063666.1 RNA Sequence

    9. XR_007063661.1 RNA Sequence

    10. XR_007063662.1 RNA Sequence

    11. XR_941518.3 RNA Sequence

    12. XR_941517.3 RNA Sequence

    13. XR_941520.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      45432940..45498131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024609.1: Suppressed sequence

      Description
      NM_001024609.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.