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    LRRC63 leucine rich repeat containing 63 [ Homo sapiens (human) ]

    Gene ID: 220416, updated on 4-Oct-2020

    Summary

    Official Symbol
    LRRC63provided by HGNC
    Official Full Name
    leucine rich repeat containing 63provided by HGNC
    Primary source
    HGNC:HGNC:34296
    See related
    Ensembl:ENSG00000173988
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in testis (RPKM 1.5), prostate (RPKM 0.2) and 3 other tissues See more
    Orthologs

    Genomic context

    See LRRC63 in Genome Data Viewer
    Location:
    13q14.13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20200815 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (46211919..46277115)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (46786083..46850944)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene lymphocyte cytosolic protein 1 Neighboring gene RNA, 7SL, cytoplasmic 288, pseudogene Neighboring gene uncharacterized LOC105370192 Neighboring gene uncharacterized LOC107984578 Neighboring gene RN7SK pseudogene 5 Neighboring gene uncharacterized LOC105370194 Neighboring gene ABITRAM pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 563 Neighboring gene rubicon like autophagy enhancer Neighboring gene RNA, U2 small nuclear 6, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    Associated conditions

    Description Tests
    Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • RP11-139H14.4

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 63

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282460.2NP_001269389.1  leucine-rich repeat-containing protein 63

      Status: VALIDATED

      Source sequence(s)
      AL137141, AL139801, BC030276
      Consensus CDS
      CCDS61325.1
      UniProtKB/Swiss-Prot
      Q05C16
      UniProtKB/TrEMBL
      J3KQU2
      Related
      ENSP00000469337.1, ENST00000595396.1
      Conserved Domains (2) summary
      sd00033
      Location:347369
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:393449
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      Range
      46211919..46277115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020421.1XP_016875910.1  leucine-rich repeat-containing protein 63 isoform X1

      UniProtKB/TrEMBL
      J3KQU2
      Conserved Domains (2) summary
      sd00033
      Location:347369
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:393449
      LRR_8; Leucine rich repeat
    2. XM_017020429.1XP_016875918.1  leucine-rich repeat-containing protein 63 isoform X11

    3. XM_017020430.1XP_016875919.1  leucine-rich repeat-containing protein 63 isoform X11

    4. XM_017020422.1XP_016875911.1  leucine-rich repeat-containing protein 63 isoform X2

    5. XM_017020431.1XP_016875920.1  leucine-rich repeat-containing protein 63 isoform X12

    6. XM_011534993.1XP_011533295.1  leucine-rich repeat-containing protein 63 isoform X13

    7. XM_017020428.1XP_016875917.1  leucine-rich repeat-containing protein 63 isoform X10

    8. XM_011534992.2XP_011533294.1  leucine-rich repeat-containing protein 63 isoform X10

      Related
      ENSP00000502820.1, ENST00000674837.1
    9. XM_017020424.1XP_016875913.1  leucine-rich repeat-containing protein 63 isoform X4

      Related
      ENSP00000501680.1, ENST00000675195.1
    10. XM_011534989.2XP_011533291.1  leucine-rich repeat-containing protein 63 isoform X8

      Related
      ENSP00000501788.1, ENST00000676025.1
    11. XM_017020425.1XP_016875914.1  leucine-rich repeat-containing protein 63 isoform X5

      Related
      ENSP00000502368.1, ENST00000674850.1
    12. XM_017020426.1XP_016875915.1  leucine-rich repeat-containing protein 63 isoform X6

      Related
      ENSP00000502389.1, ENST00000675095.1
    13. XM_017020427.1XP_016875916.1  leucine-rich repeat-containing protein 63 isoform X7

    14. XM_011534990.2XP_011533292.1  leucine-rich repeat-containing protein 63 isoform X9

    15. XM_017020423.1XP_016875912.1  leucine-rich repeat-containing protein 63 isoform X3

    RNA

    1. XR_001749493.1 RNA Sequence

    2. XR_941519.2 RNA Sequence

    3. XR_001749492.1 RNA Sequence

    4. XR_001749498.1 RNA Sequence

      Related
      ENST00000674570.1
    5. XR_941518.2 RNA Sequence

    6. XR_941520.2 RNA Sequence

    7. XR_941517.2 RNA Sequence

    8. XR_001749496.1 RNA Sequence

    9. XR_001749494.1 RNA Sequence

    10. XR_001749497.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024609.1: Suppressed sequence

      Description
      NM_001024609.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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