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    DLEU7 deleted in lymphocytic leukemia 7 [ Homo sapiens (human) ]

    Gene ID: 220107, updated on 5-Aug-2022

    Summary

    Official Symbol
    DLEU7provided by HGNC
    Official Full Name
    deleted in lymphocytic leukemia 7provided by HGNC
    Primary source
    HGNC:HGNC:17567
    See related
    Ensembl:ENSG00000186047 MIM:618634; AllianceGenome:HGNC:17567
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DLEU7 in Genome Data Viewer
    Location:
    13q14.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (50711026..50843939, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (49925974..50058890, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (51285162..51418075, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene LINE-1 retrotransposable element ORF2 protein-like Neighboring gene Sharpr-MPRA regulatory region 8262 Neighboring gene uncharacterized LOC107984568 Neighboring gene DLEU7 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 28 Neighboring gene RNASEH2B antisense RNA 1 Neighboring gene ribonuclease H2 subunit B Neighboring gene guanylate cyclase 1 soluble subunit beta 2 (pseudogene) Neighboring gene RNA, 5S ribosomal pseudogene 29

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analysis identifies 20 loci that influence adult height.
    EBI GWAS Catalog
    Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
    EBI GWAS Catalog
    Genome-wide association study of lung function decline in adults with and without asthma.
    EBI GWAS Catalog
    Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog
    Many sequence variants affecting diversity of adult human height.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog
    Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.
    EBI GWAS Catalog

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ44882, MGC138214

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    leukemia-associated protein 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306135.2NP_001293064.1  leukemia-associated protein 7 isoform 1

      See identical proteins and their annotated locations for NP_001293064.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL137880
      Consensus CDS
      CCDS76635.1
      UniProtKB/Swiss-Prot
      Q6UYE1, Q6ZT82
      Related
      ENSP00000427177.1, ENST00000504404.2
      Conserved Domains (1) summary
      pfam15760
      Location:28221
      DLEU7; Leukemia-associated protein 7
    2. NM_198989.3NP_945340.2  leukemia-associated protein 7 isoform 2

      See identical proteins and their annotated locations for NP_945340.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate 3' exon and contains an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC007304, AK126830, AW290996, BM931512, DN992279
      Consensus CDS
      CCDS53869.1
      UniProtKB/Swiss-Prot
      Q6UYE1
      Related
      ENSP00000420976.1, ENST00000400393.3
      Conserved Domains (1) summary
      pfam15760
      Location:28153
      DLEU7; Leukemia-associated protein 7

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      50711026..50843939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      49925974..50058890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)