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    FABP7 fatty acid binding protein 7 [ Homo sapiens (human) ]

    Gene ID: 2173, updated on 7-Dec-2018

    Summary

    Official Symbol
    FABP7provided by HGNC
    Official Full Name
    fatty acid binding protein 7provided by HGNC
    Primary source
    HGNC:HGNC:3562
    See related
    Ensembl:ENSG00000164434 MIM:602965
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRG; BLBP; FABPB; B-FABP
    Summary
    The gene encodes a small, highly conserved cytoplasmic protein that bind long-chain fatty acids and other hydrophobic ligands. The encoded protein is important in the establishment of the radial glial fiber in the developing brain. Alternative splicing and promoter usage results in multiple transcript variants encoding different isoforms. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Jan 2016]
    Expression
    Biased expression in brain (RPKM 8.9) and skin (RPKM 0.4) See more
    Orthologs

    Genomic context

    See FABP7 in Genome Data Viewer
    Location:
    6q22.31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (122749201..122784077)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (123100646..123105219)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267966 Neighboring gene RNA, 7SL, cytoplasmic 564, pseudogene Neighboring gene sphingomyelin phosphodiesterase acid like 3A Neighboring gene ATP synthase membrane subunit g pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, organism-specific biosystem (from REACTOME)
      Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, organism-specific biosystemTriacylglycerol is a major energy store in the body and its hydrolysis to yield fatty acids and glycerol is a tightly regulated part of energy metabolism. A central part in this regulation is played ...
    • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
      Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • PPAR signaling pathway, organism-specific biosystem (from KEGG)
      PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • PPAR signaling pathway, conserved biosystem (from KEGG)
      PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • DKFZp547J2313

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell proliferation in forebrain IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    prepulse inhibition IEA
    Inferred from Electronic Annotation
    more info
     
    triglyceride catabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cell periphery IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    fatty acid-binding protein, brain
    Names
    brain lipid-binding protein
    brain-type fatty acid-binding protein
    hypothetical protein DKFZp547J2313
    mammary-derived growth inhibitor-related

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050619.1 RefSeqGene

      Range
      35275..39877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001319039.1NP_001305968.1  fatty acid-binding protein, brain isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is longer than isoform 1.
      Source sequence(s)
      AL512688, AL645811, BI860090
      Consensus CDS
      CCDS83121.1
      UniProtKB/Swiss-Prot
      O15540
      Related
      ENSP00000348931.4, ENST00000356535.4
      Conserved Domains (1) summary
      pfam00061
      Location:8117
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    2. NM_001319041.1NP_001305970.1  fatty acid-binding protein, brain isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) retains two alternate segments compared to variant 1, resulting in a distinct 3' coding region and 3' UTR. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AB208815, AL645811, BI860090, BU736791, BX461253
      UniProtKB/TrEMBL
      Q59HE4
      Conserved Domains (1) summary
      pfam00061
      Location:883
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    3. NM_001319042.1NP_001305971.1  fatty acid-binding protein, brain isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1. The 5' end of this transcript contains long terminal repeat (LTR) sequence and initiates from an LTR promoter. (PMID: 25114248)
      Source sequence(s)
      AW156936, BU736791, KM111186
      UniProtKB/TrEMBL
      A0A077H155
      Conserved Domains (1) summary
      pfam00061
      Location:21128
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    4. NM_001446.5NP_001437.1  fatty acid-binding protein, brain isoform 1

      See identical proteins and their annotated locations for NP_001437.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AW156936, BC012299
      Consensus CDS
      CCDS5127.1
      UniProtKB/Swiss-Prot
      O15540
      Related
      ENSP00000357429.3, ENST00000368444.7
      Conserved Domains (1) summary
      pfam00061
      Location:8132
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

      Range
      122749201..122784077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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