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    ERV3-1 endogenous retrovirus group 3 member 1, envelope [ Homo sapiens (human) ]

    Gene ID: 2086, updated on 12-Aug-2018

    Summary

    Official Symbol
    ERV3-1provided by HGNC
    Official Full Name
    endogenous retrovirus group 3 member 1, envelopeprovided by HGNC
    Primary source
    HGNC:HGNC:3454
    See related
    Ensembl:ENSG00000213462 MIM:131170; Vega:OTTHUMG00000165023
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERV3; ERVR; envR; ERV-R; HERVR; HERV-R
    Summary
    This gene contains sequence derived from endogenous retrovirus, and is therefore similar to multiple other loci in the genome. Transcripts at this locus encode a conserved protein with a predicted signal peptide and similarity to the Env polyprotein. This protein is overexpressed in colorectal and other cancers. [provided by RefSeq, Jan 2017]
    Expression
    Ubiquitous expression in adrenal (RPKM 19.4), fat (RPKM 15.6) and 23 other tissues See more
    Orthologs

    Genomic context

    See ERV3-1 in Genome Data Viewer
    Location:
    7q11.21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (64990355..65006746, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (64450733..64467124, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375328 Neighboring gene ERV3-1-ZNF117 readthrough Neighboring gene vomeronasal 1 receptor 43 pseudogene Neighboring gene zinc finger protein 117 Neighboring gene uncharacterized LOC105375330 Neighboring gene RNA, U6 small nuclear 1229, pseudogene Neighboring gene uncharacterized LOC105375329

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough ERV3-1-ZNF117

    Readthrough gene: ERV3-1-ZNF117, Included gene: ZNF117

    Homology

    Clone Names

    • FLJ23884

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    endogenous retrovirus group 3 member 1 Env polyprotein
    Names
    ERV-R envelope protein
    ERV3-1 envelope protein
    HERV-R envelope protein
    HERV-R_7q21.2 provirus ancestral Env polyprotein
    endogenous retroviral sequence 3
    endogenous retrovirus group 3, member 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007253.3NP_001007254.2  endogenous retrovirus group 3 member 1 Env polyprotein precursor

      See identical proteins and their annotated locations for NP_001007254.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the protein related to endogenous retrovirus.
      Source sequence(s)
      AC073210, AK074464, DA198800
      Consensus CDS
      CCDS47595.1
      UniProtKB/Swiss-Prot
      Q14264
      Related
      ENSP00000391594.1, OTTHUMP00000228206, ENST00000394323.2, OTTHUMT00000381468
      Conserved Domains (1) summary
      cd09850
      Location:521597
      Ebola-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region of the transmembrane subunit of Filoviridae viruses, Ebola virus and Marburg virus, and related domains

    RNA

    1. NR_145414.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' exon and lacks the open reading frame found in variant 1.
      Source sequence(s)
      AC073210, AK097499, DA198800
      Related
      ENST00000528878.1
    2. NR_145415.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' exon and lacks the open reading frame found in variant 1.
      Source sequence(s)
      DA198800, F27725
      Related
      ENST00000535538.1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

      Range
      64990355..65006746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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