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    Spn sialophorin [ Mus musculus (house mouse) ]

    Gene ID: 20737, updated on 23-Feb-2019

    Summary

    Official Symbol
    Spnprovided by MGI
    Official Full Name
    sialophorinprovided by MGI
    Primary source
    MGI:MGI:98384
    See related
    Ensembl:ENSMUSG00000051457
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd43; Ly48; Galgp; Ly-48; A630014B01Rik
    Expression
    Biased expression in thymus adult (RPKM 26.4), spleen adult (RPKM 15.5) and 6 other tissues See more
    Orthologs

    Genomic context

    See Spn in Genome Data Viewer
    Location:
    7 F3; 7 69.35 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (127123633..127144614, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (134276978..134281331, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene expressed sequence AI467606 Neighboring gene quinolinate phosphoribosyltransferase Neighboring gene TAR (HIV) RNA binding protein 2 pseudogene Neighboring gene CD2 cytoplasmic tail binding protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    T cell costimulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    T-helper 1 cell lineage commitment ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    interferon-gamma production ISO
    Inferred from Sequence Orthology
    more info
     
    leukocyte tethering or rolling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of type IV hypersensitivity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of tumor necrosis factor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of tumor necrosis factor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of T cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of T cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to protozoan IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thymocyte aggregation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    uropod IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    leukosialin
    Names
    3E8 antigen
    B-cell differentiation antigen LP-3
    leukocyte sialoglycoprotein
    lymphocyte antigen 48

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037810.2NP_001032899.1  leukosialin precursor

      See identical proteins and their annotated locations for NP_001032899.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC122537, AK041712, AK134098
      Consensus CDS
      CCDS21858.1
      UniProtKB/Swiss-Prot
      P15702
      UniProtKB/TrEMBL
      Q544C5
      Related
      ENSMUSP00000122787.1, ENSMUST00000143713.1
      Conserved Domains (1) summary
      pfam15782
      Location:100246
      GREB1; Gene regulated by oestrogen in breast cancer
    2. NM_009259.5NP_033285.1  leukosialin precursor

      See identical proteins and their annotated locations for NP_033285.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC122537, AK077764, AK134098, AW540100
      Consensus CDS
      CCDS21858.1
      UniProtKB/Swiss-Prot
      P15702
      UniProtKB/TrEMBL
      Q544C5
      Related
      ENSMUSP00000049534.5, ENSMUST00000049931.5
      Conserved Domains (1) summary
      pfam15782
      Location:100246
      GREB1; Gene regulated by oestrogen in breast cancer

    RNA

    1. NR_110337.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains 2 novel exons at the 3' end compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC122537, AK041480

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      127123633..127144614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241717.2XP_011240019.1  leukosialin isoform X1

      See identical proteins and their annotated locations for XP_011240019.1

      Conserved Domains (1) summary
      pfam15782
      Location:115261
      GREB1; Gene regulated by oestrogen in breast cancer
    2. XM_011241716.2XP_011240018.1  leukosialin isoform X1

      See identical proteins and their annotated locations for XP_011240018.1

      Conserved Domains (1) summary
      pfam15782
      Location:115261
      GREB1; Gene regulated by oestrogen in breast cancer
    3. XM_006507522.3XP_006507585.1  leukosialin isoform X2

      See identical proteins and their annotated locations for XP_006507585.1

      UniProtKB/Swiss-Prot
      P15702
      UniProtKB/TrEMBL
      Q544C5
      Conserved Domains (1) summary
      pfam15782
      Location:100246
      GREB1; Gene regulated by oestrogen in breast cancer

    RNA

    1. XR_001785500.1 RNA Sequence

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