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    Slc4a1 solute carrier family 4 (anion exchanger), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20533, updated on 31-Jan-2019

    Summary

    Official Symbol
    Slc4a1provided by MGI
    Official Full Name
    solute carrier family 4 (anion exchanger), member 1provided by MGI
    Primary source
    MGI:MGI:109393
    See related
    Ensembl:ENSMUSG00000006574
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ae1; CD233; Empb3; l11Jus51
    Expression
    Biased expression in liver E14.5 (RPKM 452.9), liver E14 (RPKM 362.2) and 4 other tissues See more
    Orthologs

    Genomic context

    See Slc4a1 in Genome Data Viewer
    Location:
    11 66.29 cM; 11 D
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (102348820..102365281, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (102210134..102226595, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33851 Neighboring gene upstream binding transcription factor, RNA polymerase I Neighboring gene Bloodlinc, erythroid developmental long intergenic non-protein coding transcript Neighboring gene predicted gene, 34253 Neighboring gene RUN domain containing 3A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    anion:anion antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    ankyrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    bicarbonate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    chloride transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    inorganic anion exchanger activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    anion transport ISO
    Inferred from Sequence Orthology
    more info
     
    bicarbonate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    bicarbonate transport ISO
    Inferred from Sequence Orthology
    more info
     
    chloride transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to activity ISO
    Inferred from Sequence Orthology
    more info
     
    response to arsenic-containing substance ISO
    Inferred from Sequence Orthology
    more info
     
    response to carbon dioxide ISO
    Inferred from Sequence Orthology
    more info
     
    response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cortical cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    band 3 anion transport protein
    Names
    AE 1
    MEB3
    anion exchange protein 1
    anion exchanger 1
    erythrocyte membrane protein band 3
    solute carrier family 4 member 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011403.2NP_035533.1  band 3 anion transport protein

      See identical proteins and their annotated locations for NP_035533.1

      Status: VALIDATED

      Source sequence(s)
      AK158143, BC052419, W75328
      Consensus CDS
      CCDS25496.1
      UniProtKB/Swiss-Prot
      P04919
      UniProtKB/TrEMBL
      Q3TZ29, Q53ZN9
      Related
      ENSMUSP00000006749.9, ENSMUST00000006749.9
      Conserved Domains (3) summary
      TIGR00834
      Location:72928
      ae; anion exchange protein
      pfam00955
      Location:391857
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:100342
      Band_3_cyto; Band 3 cytoplasmic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      102348820..102365281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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