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    Slc4a1 solute carrier family 4 (anion exchanger), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20533, updated on 12-May-2024

    Summary

    Official Symbol
    Slc4a1provided by MGI
    Official Full Name
    solute carrier family 4 (anion exchanger), member 1provided by MGI
    Primary source
    MGI:MGI:109393
    See related
    Ensembl:ENSMUSG00000006574 AllianceGenome:MGI:109393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ae1; CD233; Empb3; l11Jus51
    Summary
    Enables anion transmembrane transporter activity; ankyrin binding activity; and hemoglobin binding activity. Involved in chloride transport. Acts upstream of or within several processes, including bicarbonate transport; erythrocyte development; and negative regulation of glycolytic process through fructose-6-phosphate. Located in basolateral plasma membrane; cortical cytoskeleton; and cytoplasmic side of plasma membrane. Is expressed in several structures, including blood; blood vessel; liver; lung; and metanephros. Used to study hereditary spherocytosis type 4 and renal tubular acidosis. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; hereditary spherocytosis type 4; malaria; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E14.5 (RPKM 452.9), liver E14 (RPKM 362.2) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Slc4a1 in Genome Data Viewer
    Location:
    11 66.29 cM; 11 D
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102239646..102256107, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102348820..102365281, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E469 Neighboring gene ataxin 7-like 3 Neighboring gene predicted gene, 33851 Neighboring gene STARR-positive B cell enhancer ABC_E5281 Neighboring gene upstream binding transcription factor, RNA polymerase I Neighboring gene STARR-seq mESC enhancer starr_30800 Neighboring gene Bloodlinc, erythroid developmental long intergenic non-protein coding transcript Neighboring gene predicted gene, 34253 Neighboring gene STARR-positive B cell enhancer ABC_E11495 Neighboring gene RUN domain containing 3A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (2) 
    • Spontaneous (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ankyrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ankyrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables bicarbonate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables bicarbonate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables bicarbonate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chloride transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chloride:bicarbonate antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables chloride:bicarbonate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hemoglobin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables monoatomic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables solute:inorganic anion antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in bicarbonate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within bicarbonate transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in bicarbonate transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chloride transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within erythrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic anion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of glycolytic process through fructose-6-phosphate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of oxidoreductase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of urine volume IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within pH elevation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within plasma membrane phospholipid scrambling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to arsenic-containing substance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to carbon dioxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ankyrin-1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cortical cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    band 3 anion transport protein
    Names
    AE 1
    MEB3
    anion exchange protein 1
    anion exchanger 1
    erythrocyte membrane protein band 3
    solute carrier family 4 member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011403.3NP_035533.1  band 3 anion transport protein

      See identical proteins and their annotated locations for NP_035533.1

      Status: VALIDATED

      Source sequence(s)
      AL596258, AL954730
      Consensus CDS
      CCDS25496.1
      UniProtKB/Swiss-Prot
      P04919
      UniProtKB/TrEMBL
      Q3TAJ4, Q3TNL6, Q3TZJ1, Q53ZN9
      Related
      ENSMUSP00000006749.10, ENSMUST00000006749.10
      Conserved Domains (3) summary
      TIGR00834
      Location:72928
      ae; anion exchange protein
      pfam00955
      Location:391857
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:100342
      Band_3_cyto; Band 3 cytoplasmic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      102239646..102256107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)