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    EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 1978, updated on 7-Jan-2024

    Summary

    Official Symbol
    EIF4EBP1provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 4E binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:3288
    See related
    Ensembl:ENSG00000187840 MIM:602223; AllianceGenome:HGNC:3288
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BP-1; 4EBP1; 4E-BP1; PHAS-I
    Summary
    This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in salivary gland (RPKM 30.3), fat (RPKM 26.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See EIF4EBP1 in Genome Data Viewer
    Location:
    8p11.23
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (38030534..38060365)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (38306935..38336767)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (37888052..37917883)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:37792805-37793306 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:37797148-37797664 Neighboring gene glutamic-oxaloacetic transaminase 1 like 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:37823116-37823850 Neighboring gene adrenoceptor beta 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:37845776-37845966 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:37871736-37871907 Neighboring gene NANOG hESC enhancer GRCh37_chr8:37872816-37873317 Neighboring gene Sharpr-MPRA regulatory region 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:37892967-37893468 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:37911667-37911880 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:37927359-37928086 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:37929540-37930265 Neighboring gene Sharpr-MPRA regulatory region 11218 Neighboring gene CRISPRi-validated cis-regulatory element chr8.1253 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:37960345-37960633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27241 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19116 Neighboring gene ASH2 like, histone lysine methyltransferase complex subunit Neighboring gene RNA, U6 small nuclear 988, pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:37990733-37991476 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:37991477-37992222 Neighboring gene Sharpr-MPRA regulatory region 4493 Neighboring gene STAR 5' regulatory region Neighboring gene steroidogenic acute regulatory protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag decreases EIF4EBP1 (4EBP1) associated with the 5' mRNA cap to enhance Gag translation PubMed
    Vpr vpr HIV-1 Vpr expression in HEK293 cells is sufficient to decrease the levels of phosphorylated eIF4E and 4E-BP1 PubMed
    nucleocapsid gag HIV-1 NC downregulates eukaryotic translation initiation factor 4E binding protein 1 in HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC4316

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables eukaryotic initiation factor 4E binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables eukaryotic initiation factor 4E binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables translation initiation factor binding EXP
    Inferred from Experiment
    more info
    PubMed 
    enables translation initiation factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables translation repressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4E-binding protein 1
    Names
    eIF4E-binding protein 1
    phosphorylated heat- and acid-stable protein regulated by insulin 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004095.4NP_004086.1  eukaryotic translation initiation factor 4E-binding protein 1

      See identical proteins and their annotated locations for NP_004086.1

      Status: REVIEWED

      Source sequence(s)
      AB044548, BC004459
      Consensus CDS
      CCDS6100.1
      UniProtKB/Swiss-Prot
      B2R502, D3DSW8, Q13541, Q6IBN3
      Related
      ENSP00000340691.4, ENST00000338825.5
      Conserved Domains (1) summary
      pfam05456
      Location:11118
      eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      38030534..38060365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      38306935..38336767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)