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    EFNB2 ephrin B2 [ Homo sapiens (human) ]

    Gene ID: 1948, updated on 20-Jun-2022

    Summary

    Official Symbol
    EFNB2provided by HGNC
    Official Full Name
    ephrin B2provided by HGNC
    Primary source
    HGNC:HGNC:3227
    See related
    Ensembl:ENSG00000125266 MIM:600527; AllianceGenome:HGNC:3227
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HTKL; EPLG5; Htk-L; LERK5; ephrin-B2
    Summary
    This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lung (RPKM 8.5), colon (RPKM 7.4) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EFNB2 in Genome Data Viewer
    Location:
    13q33.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (106489745..106535662, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (105710156..105756072, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (107142093..107188010, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35 pseudogene 7 Neighboring gene uncharacterized LOC105370346 Neighboring gene uncharacterized LOC124903247 Neighboring gene arginine and glutamate rich 1 Neighboring gene long intergenic non-protein coding RNA 551

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC126226, MGC126227, MGC126228

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ephrin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in T cell costimulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adherens junction organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in animal organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in blood vessel morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell migration involved in sprouting angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in keratinocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lymph vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of keratinocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nephric duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of aorta morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cardiac muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in presynapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in venous blood vessel morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in integral component of postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ephrin-B2
    Names
    HTK ligand
    eph-related receptor tyrosine kinase ligand 5
    ligand of eph-related kinase 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372056.1NP_001358985.1  ephrin-B2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL138689, KF455823
      Conserved Domains (1) summary
      cl19115
      Location:29142
      Cupredoxin; Cupredoxin superfamily
    2. NM_001372057.1NP_001358986.1  ephrin-B2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL138689, KF455823
      Conserved Domains (1) summary
      cd10426
      Location:29165
      Ephrin-B_Ectodomain; Ectodomain of Ephrin B
    3. NM_001372058.1NP_001358987.1  ephrin-B2 isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AL138689
      Conserved Domains (1) summary
      cl19115
      Location:29136
      Cupredoxin; Cupredoxin superfamily
    4. NM_004093.4NP_004084.1  ephrin-B2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_004084.1

      Status: REVIEWED

      Source sequence(s)
      AL138689, KF455823
      Consensus CDS
      CCDS9507.1
      UniProtKB/Swiss-Prot
      P52799
      Related
      ENSP00000493716.1, ENST00000646441.1
      Conserved Domains (1) summary
      cd10426
      Location:29165
      Ephrin-B_Ectodomain; Ectodomain of Ephrin B

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      106489745..106535662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020406.3XP_016875895.1  ephrin-B2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      105710156..105756072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)