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    Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha [ Mus musculus (house mouse) ]

    Gene ID: 19084, updated on 19-May-2018
    Official Symbol
    Prkar1aprovided by MGI
    Official Full Name
    protein kinase, cAMP dependent regulatory, type I, alphaprovided by MGI
    Primary source
    MGI:MGI:104878
    See related
    Ensembl:ENSMUSG00000020612 Vega:OTTMUSG00000003351
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tse1; Tse-1; RIalpha; 1300018C22Rik
    Summary
    The encoded protein is a regulatory subunit of the cAMP-dependent protein kinase (PKA) complex, which is responsible for transducing most of the cAMP signals in eukaryotic cells. The inactive PKA complex contains two regulatory and two catalytic subunits. Binding of cAMP dissociates the complex, allowing monomeric catalytic subunits to phosphorylate cytosolic proteins or induce gene expression in the nucleus. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 81.7), cerebellum adult (RPKM 81.5) and 28 other tissues See more
    Orthologs
    See Prkar1a in Genome Data Viewer
    Location:
    11 E1; 11 72.33 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (109649405..109669663)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (109512263..109530962)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108167935 Neighboring gene WD repeat domain, phosphoinositide interacting 1 Neighboring gene predicted gene 11685 Neighboring gene predicted gene, 39443 Neighboring gene family with sequence similarity 20, member A Neighboring gene uncharacterized LOC105243553 Neighboring gene predicted gene, 42093

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cAMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    cAMP-dependent protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    cAMP-dependent protein kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cAMP-dependent protein kinase regulator activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cAMP-dependent protein kinase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cAMP-dependent protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase A catalytic subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    cardiac muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cAMP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with axoneme ISO
    Inferred from Sequence Orthology
    more info
     
    cAMP-dependent protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    colocalizes_with immunological synapse ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide-activated protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    cAMP-dependent protein kinase type I-alpha regulatory subunit
    Names
    protein kinase, cAMP dependent regulatory, type 1, alpha
    NP_001300902.1
    NP_001300903.1
    NP_001300904.1
    NP_001300905.1
    NP_068680.1
    XP_006532572.1
    XP_017169829.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313973.2NP_001300902.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AK051068, AL732387, BB610165, BP754173, BY309580
      Consensus CDS
      CCDS25583.1
      UniProtKB/Swiss-Prot
      Q9DBC7
      Related
      ENSMUSP00000102288.1, OTTMUSP00000003354, ENSMUST00000106677.7
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    2. NM_001313974.2NP_001300903.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AK051068, AL732387, BP754173, BY129491
      Consensus CDS
      CCDS25583.1
      UniProtKB/Swiss-Prot
      Q9DBC7
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    3. NM_001313975.2NP_001300904.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AK051068, AL732387, BB850806, BP754173, CX243222
      Consensus CDS
      CCDS25583.1
      UniProtKB/Swiss-Prot
      Q9DBC7
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    4. NM_001313976.2NP_001300905.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AK051068, AL732387, BB850806, BP754173, CF727817
      Consensus CDS
      CCDS25583.1
      UniProtKB/Swiss-Prot
      Q9DBC7
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    5. NM_001362677.1NP_001349606.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AL732387, BP754173
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    6. NM_021880.4NP_068680.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      See identical proteins and their annotated locations for NP_068680.1

      Status: REVIEWED

      Source sequence(s)
      AL732387, BP754173
      Consensus CDS
      CCDS25583.1
      UniProtKB/Swiss-Prot
      Q9DBC7
      Related
      ENSMUSP00000056500.6, OTTMUSP00000003353, ENSMUST00000049527.6
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      109649405..109669663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532509.1XP_006532572.1  cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X1

      See identical proteins and their annotated locations for XP_006532572.1

      UniProtKB/TrEMBL
      Q3TYK4
      Conserved Domains (4) summary
      cd12101
      Location:143192
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      COG0664
      Location:378488
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:384499
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd13394
      Location:89171
      Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    2. XM_017314340.1XP_017169829.1  cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X2

      UniProtKB/Swiss-Prot
      Q9DBC7
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
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