Format

Send to:

Choose Destination
    • Showing Current items.

    S1PR1 sphingosine-1-phosphate receptor 1 [ Homo sapiens (human) ]

    Gene ID: 1901, updated on 13-Feb-2019

    Summary

    Official Symbol
    S1PR1provided by HGNC
    Official Full Name
    sphingosine-1-phosphate receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:3165
    See related
    Ensembl:ENSG00000170989 MIM:601974
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362
    Summary
    The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
    Expression
    Broad expression in fat (RPKM 52.5), lung (RPKM 39.5) and 21 other tissues See more
    Orthologs

    Genomic context

    See S1PR1 in Genome Data Viewer
    Location:
    1p21.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (101236749..101241520)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (101702305..101707076)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928334 Neighboring gene uncharacterized LOC101928370 Neighboring gene ribosomal protein S20 pseudogene 6 Neighboring gene peptidylprolyl isomerase A pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of sphingosine-1-phosphate receptor 1 (S1PR1) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ58121

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    G protein-coupled receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sphingolipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    sphingosine-1-phosphate receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    T cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin cytoskeleton reorganization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    blood vessel maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    brain development IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac muscle tissue growth involved in heart morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    endothelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    heart trabecula morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lamellipodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    leukocyte chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of bone resorption ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    sphingosine-1-phosphate receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmission of nerve impulse IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    intrinsic component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    sphingosine 1-phosphate receptor 1
    Names
    S1P receptor 1
    S1P receptor Edg-1
    endothelial differentiation G-protein coupled receptor 1
    endothelial differentiation, sphingolipid G-protein-coupled receptor, 1
    sphingosine 1-phosphate receptor EDG1
    sphingosine 1-phosphate receptor Edg-1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016181.1 RefSeqGene

      Range
      5001..9772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001320730.1NP_001307659.1  sphingosine 1-phosphate receptor 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL109741, BP236900
      Consensus CDS
      CCDS777.1
      UniProtKB/Swiss-Prot
      P21453
      Related
      ENSP00000498038.1, ENST00000475289.2
      Conserved Domains (1) summary
      cd15346
      Location:46322
      7tmA_S1PR1_Edg1; sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001400.4NP_001391.2  sphingosine 1-phosphate receptor 1

      See identical proteins and their annotated locations for NP_001391.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC018650, CR977007, DB132417, DB572979
      Consensus CDS
      CCDS777.1
      UniProtKB/Swiss-Prot
      P21453
      Related
      ENSP00000305416.6, ENST00000305352.6
      Conserved Domains (1) summary
      cd15346
      Location:46322
      7tmA_S1PR1_Edg1; sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      101236749..101241520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center