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    ECT2 epithelial cell transforming 2 [ Homo sapiens (human) ]

    Gene ID: 1894, updated on 7-Oct-2018

    Summary

    Official Symbol
    ECT2provided by HGNC
    Official Full Name
    epithelial cell transforming 2provided by HGNC
    Primary source
    HGNC:HGNC:3155
    See related
    Ensembl:ENSG00000114346 MIM:600586; Vega:OTTHUMG00000156762
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARHGEF31
    Summary
    The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]
    Expression
    Broad expression in testis (RPKM 6.4), colon (RPKM 5.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See ECT2 in Genome Data Viewer
    Location:
    3q26.31
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (172750685..172829273)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (172468425..172539264)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene neutral cholesterol ester hydrolase 1 Neighboring gene nucleosome assembly protein 1 like 5 pseudogene Neighboring gene RNA, U6 small nuclear 547, pseudogene Neighboring gene RNA, U4 small nuclear 4, pseudogene Neighboring gene ATP synthase membrane subunit c locus 1 pseudogene 4 Neighboring gene uncharacterized LOC107986052 Neighboring gene spermatogenesis associated 16 Neighboring gene uncharacterized LOC105374221

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
      Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
    • G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Gastric Cancer Network 1, organism-specific biosystem (from WikiPathways)
      Gastric Cancer Network 1, organism-specific biosystemNetwork generated by mapping candidate oncogenes and tumor suppressor genes identified by integrated analysis of expression array and aCGH data. Networks generated by Ingenuity Pathway Analysis.
    • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
      NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
    • PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      PLK1 signaling events, organism-specific biosystem
      PLK1 signaling events
    • Regulation of RhoA activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of RhoA activity, organism-specific biosystem
      Regulation of RhoA activity
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
      p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10461, MGC138291

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Rho guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rho guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    activation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bicellular tight junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to ionizing radiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    positive regulation of cytokinesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein import into nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cytokinesis, actomyosin contractile ring assembly IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centralspindlin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein ECT2
    Names
    epithelial cell-transforming sequence 2 oncogene

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258315.1NP_001245244.1  protein ECT2 isoform a

      See identical proteins and their annotated locations for NP_001245244.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variants 8, 9, and 10, encodes the isoform (a).
      Source sequence(s)
      BC070038, DB229273, DQ847274
      Consensus CDS
      CCDS58860.1
      UniProtKB/Swiss-Prot
      Q9H8V3
      Related
      ENSP00000376457.3, OTTHUMP00000210685, ENST00000392692.7, OTTHUMT00000345994
      Conserved Domains (4) summary
      smart00325
      Location:456640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:179242
      PTCB-BRCT; twin BRCT domain
    2. NM_001258316.1NP_001245245.1  protein ECT2 isoform b

      See identical proteins and their annotated locations for NP_001245245.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variant 3, encodes isoform b.
      Source sequence(s)
      AY376439, BC070038, BC112086, DB229273, DC406772
      Consensus CDS
      CCDS3220.1
      UniProtKB/Swiss-Prot
      Q9H8V3
      Related
      ENSP00000443160.2, ENST00000540509.5
      Conserved Domains (4) summary
      smart00325
      Location:425609
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:600773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:235310
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:148211
      PTCB-BRCT; twin BRCT domain
    3. NM_001349094.1NP_001336023.1  protein ECT2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (c). Variants 4, 5, and 6 all encode the same isoform (c).
      Source sequence(s)
      AC108667
      Conserved Domains (4) summary
      smart00325
      Location:456640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:179242
      PTCB-BRCT; twin BRCT domain
    4. NM_001349095.1NP_001336024.1  protein ECT2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform c.
      Source sequence(s)
      AC108667
      Conserved Domains (4) summary
      smart00325
      Location:456640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:179242
      PTCB-BRCT; twin BRCT domain
    5. NM_001349096.1NP_001336025.1  protein ECT2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform c.
      Source sequence(s)
      AC108667
      Conserved Domains (4) summary
      smart00325
      Location:456640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:179242
      PTCB-BRCT; twin BRCT domain
    6. NM_001349097.1NP_001336026.1  protein ECT2 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) encodes isoform d.
      Source sequence(s)
      AC108667
      Conserved Domains (4) summary
      smart00325
      Location:455639
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:630803
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:265340
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:178241
      PTCB-BRCT; twin BRCT domain
    7. NM_001349098.1NP_001336027.1  protein ECT2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 1, 9, and 10, encodes isoform a.
      Source sequence(s)
      AC108667
      Consensus CDS
      CCDS58860.1
      Conserved Domains (4) summary
      smart00325
      Location:456640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:179242
      PTCB-BRCT; twin BRCT domain
    8. NM_001349099.1NP_001336028.1  protein ECT2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 1, 8, and 10, encodes isoform a.
      Source sequence(s)
      AC108667
      Consensus CDS
      CCDS58860.1
      Conserved Domains (4) summary
      smart00325
      Location:456640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:179242
      PTCB-BRCT; twin BRCT domain
    9. NM_001349100.1NP_001336029.1  protein ECT2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 1, 8, and 9, encodes isoform a.
      Source sequence(s)
      AC108667
      Consensus CDS
      CCDS58860.1
      Conserved Domains (4) summary
      smart00325
      Location:456640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:179242
      PTCB-BRCT; twin BRCT domain
    10. NM_001349101.1NP_001336030.1  protein ECT2 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) encodes isoform e.
      Source sequence(s)
      AC108667
      Conserved Domains (4) summary
      smart00325
      Location:425609
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:600773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:235310
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:148211
      PTCB-BRCT; twin BRCT domain
    11. NM_001349102.1NP_001336031.1  protein ECT2 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) encodes isoform f.
      Source sequence(s)
      AC108667
      Consensus CDS
      CCDS87168.1
      Related
      ENSP00000415876.1, ENST00000417960.5
      Conserved Domains (4) summary
      smart00325
      Location:424608
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:599772
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:234309
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:147210
      PTCB-BRCT; twin BRCT domain
    12. NM_001349103.1NP_001336032.1  protein ECT2 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variant 14, encodes isoform g.
      Source sequence(s)
      AC108667
      Conserved Domains (4) summary
      smart00325
      Location:396580
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:571744
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:235310
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:148211
      PTCB-BRCT; twin BRCT domain
    13. NM_001349104.1NP_001336033.1  protein ECT2 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variant 13, encodes isoform g.
      Source sequence(s)
      AC108667
      Conserved Domains (4) summary
      smart00325
      Location:396580
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:571744
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:235310
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:148211
      PTCB-BRCT; twin BRCT domain
    14. NM_018098.5NP_060568.3  protein ECT2 isoform b

      See identical proteins and their annotated locations for NP_060568.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variant 2, encodes isoform b.
      Source sequence(s)
      BC070038, BC112086, DB229273
      Consensus CDS
      CCDS3220.1
      UniProtKB/Swiss-Prot
      Q9H8V3
      Related
      ENSP00000232458.5, OTTHUMP00000210684, ENST00000232458.9, OTTHUMT00000345993
      Conserved Domains (4) summary
      smart00325
      Location:425609
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:600773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:235310
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:148211
      PTCB-BRCT; twin BRCT domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

      Range
      172750685..172829273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005831.1XP_016861320.1  protein ECT2 isoform X2

    2. XM_011512514.2XP_011510816.1  protein ECT2 isoform X1

      See identical proteins and their annotated locations for XP_011510816.1

      UniProtKB/Swiss-Prot
      Q9H8V3
      Conserved Domains (4) summary
      smart00325
      Location:456640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:179242
      PTCB-BRCT; twin BRCT domain
    3. XM_006713524.4XP_006713587.1  protein ECT2 isoform X4

      Conserved Domains (4) summary
      cd01229
      Location:631804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00621
      Location:456640
      RhoGEF; RhoGEF domain
      pfam12738
      Location:179242
      PTCB-BRCT; twin BRCT domain
    4. XM_017005832.1XP_016861321.1  protein ECT2 isoform X3

      Conserved Domains (4) summary
      smart00325
      Location:425609
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:600773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:235310
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:148211
      PTCB-BRCT; twin BRCT domain
    5. XM_005247176.2XP_005247233.1  protein ECT2 isoform X3

      See identical proteins and their annotated locations for XP_005247233.1

      Conserved Domains (4) summary
      smart00325
      Location:425609
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:600773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:235310
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:148211
      PTCB-BRCT; twin BRCT domain
    6. XM_011512516.1XP_011510818.1  protein ECT2 isoform X3

      See identical proteins and their annotated locations for XP_011510818.1

      Conserved Domains (4) summary
      smart00325
      Location:425609
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:600773
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:235310
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:148211
      PTCB-BRCT; twin BRCT domain
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