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    Notch4 notch 4 [ Mus musculus (house mouse) ]

    Gene ID: 18132, updated on 31-Jan-2019

    Summary

    Official Symbol
    Notch4provided by MGI
    Official Full Name
    notch 4provided by MGI
    Primary source
    MGI:MGI:107471
    See related
    Ensembl:ENSMUSG00000015468
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N4; Int3; Int-3
    Expression
    Biased expression in lung adult (RPKM 37.2), adrenal adult (RPKM 14.3) and 14 other tissues See more
    Orthologs

    Genomic context

    See Notch4 in Genome Data Viewer
    Location:
    17 B1; 17 18.15 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (34564277..34588543)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34701240..34725488)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene butyrophilin-like 6 Neighboring gene butyrophilin-like 7, pseudogene Neighboring gene predicted gene, 31560 Neighboring gene G-protein signalling modulator 3 (AGS3-like, C. elegans) Neighboring gene pre B cell leukemia homeobox 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Notch binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Notch signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    branching involved in blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    endothelial cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    mammary gland development ISO
    Inferred from Sequence Orthology
    more info
     
    morphogenesis of a branching structure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of endothelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of aorta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of developmental process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    venous blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neurogenic locus notch homolog protein 4
    Names
    Notch gene homolog 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010929.2NP_035059.2  neurogenic locus notch homolog protein 4 precursor

      See identical proteins and their annotated locations for NP_035059.2

      Status: VALIDATED

      Source sequence(s)
      CT009767
      Consensus CDS
      CCDS28647.1
      UniProtKB/Swiss-Prot
      P31695
      UniProtKB/TrEMBL
      A2CG28
      Related
      ENSMUSP00000015612.7, ENSMUST00000015612.13
      Conserved Domains (8) summary
      smart00179
      Location:191229
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:429470
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00204
      Location:16281735
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00066
      Location:12531281
      Notch; LNR domain
      pfam06816
      Location:12911337
      NOD; NOTCH protein
      pfam07684
      Location:13761415
      NODP; NOTCH protein
      pfam12796
      Location:16331726
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:16291659
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      34564277..34588543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523798.3XP_006523861.1  neurogenic locus notch homolog protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006523861.1

      Conserved Domains (7) summary
      smart00179
      Location:195233
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:433474
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00204
      Location:16321739
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00066
      Location:12571285
      Notch; LNR domain
      pfam07684
      Location:13801419
      NODP; NOTCH protein
      pfam12796
      Location:16371730
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:16331663
      ANK; ANK repeat [structural motif]

    RNA

    1. XR_385298.3 RNA Sequence

    Reference GRCm38.p4 129X1/SvJ

    Genomic

    1. NT_039662.3 Reference GRCm38.p4 129X1/SvJ

      Range
      813088..837312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187027.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      883775..908111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/ShiLtJ

    Genomic

    1. NT_187004.1 Reference GRCm38.p4 NOD/ShiLtJ

      Range
      884023..908362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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