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    Notch4 notch 4 [ Mus musculus (house mouse) ]

    Gene ID: 18132, updated on 26-Sep-2022

    Summary

    Official Symbol
    Notch4provided by MGI
    Official Full Name
    notch 4provided by MGI
    Primary source
    MGI:MGI:107471
    See related
    Ensembl:ENSMUSG00000015468 AllianceGenome:MGI:107471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N4; Int3; Int-3
    Summary
    Enables Notch binding activity. Involved in branching involved in blood vessel morphogenesis and negative regulation of endothelial cell differentiation. Acts upstream of or within several processes, including negative regulation of Notch signaling pathway; positive regulation of angiogenesis; and positive regulation of aorta morphogenesis. Located in cytoplasmic vesicle and endoplasmic reticulum. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and hemolymphoid system gland. Used to study arteriovenous malformations of the brain. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); dementia; ductal carcinoma in situ; schizophrenia; and systemic scleroderma. Orthologous to human NOTCH4 (notch receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 37.2), adrenal adult (RPKM 14.3) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Notch4 in Genome Data Viewer
    Location:
    17 B1; 17 18.15 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34783257..34807517)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34564286..34588543)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene butyrophilin-like 6 Neighboring gene butyrophilin-like 7, pseudogene Neighboring gene predicted gene, 31560 Neighboring gene G-protein signalling modulator 3 (AGS3-like, C. elegans) Neighboring gene pre B cell leukemia homeobox 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Notch binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables Notch binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Notch signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in branching involved in blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mammary gland development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in morphogenesis of a branching structure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell adhesion molecule production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell-cell adhesion mediated by cadherin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of aorta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of developmental process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within venous blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    neurogenic locus notch homolog protein 4
    Names
    Notch gene homolog 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010929.2NP_035059.2  neurogenic locus notch homolog protein 4 precursor

      See identical proteins and their annotated locations for NP_035059.2

      Status: VALIDATED

      Source sequence(s)
      CT009767
      Consensus CDS
      CCDS28647.1
      UniProtKB/Swiss-Prot
      P31695, Q9R1X0
      UniProtKB/TrEMBL
      A2CG28
      Related
      ENSMUSP00000015612.8, ENSMUST00000015612.14
      Conserved Domains (9) summary
      PTZ00322
      Location:17481828
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      smart00004
      Location:12031241
      NL; Domain found in Notch and Lin-12
      smart00179
      Location:191229
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:429470
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:16291659
      ANK; ANK repeat [structural motif]
      pfam06816
      Location:12911337
      NOD; NOTCH protein
      pfam07684
      Location:13761415
      NODP; NOTCH protein
      pfam00066
      Location:12531281
      Notch; LNR domain
      pfam12796
      Location:16331726
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34783257..34807517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160366.1XP_036016259.1  neurogenic locus notch homolog protein 4 isoform X2

      Conserved Domains (6) summary
      smart00004
      Location:12071245
      NL; Domain found in Notch and Lin-12
      smart00179
      Location:195233
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:433474
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00066
      Location:12551284
      Notch; LNR domain
      pfam06816
      Location:12951344
      NOD; NOTCH protein
      pfam07684
      Location:13791419
      NODP; NOTCH protein
    2. XM_006523798.4XP_006523861.1  neurogenic locus notch homolog protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006523861.1

      Conserved Domains (7) summary
      smart00004
      Location:12071245
      NL; Domain found in Notch and Lin-12
      smart00179
      Location:195233
      EGF_CA; Calcium-binding EGF-like domain
      COG0666
      Location:16441819
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00054
      Location:433474
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00045
      Location:16331663
      ANK; ANK repeat [structural motif]
      pfam00066
      Location:12571285
      Notch; LNR domain
      pfam12796
      Location:16371730
      Ank_2; Ankyrin repeats (3 copies)

    RNA

    1. XR_004939477.1 RNA Sequence

      Related
      ENSMUST00000173389.8
    2. XR_385298.5 RNA Sequence