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    DPAGT1 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 [ Homo sapiens (human) ]

    Gene ID: 1798, updated on 10-Nov-2018

    Summary

    Official Symbol
    DPAGT1provided by HGNC
    Official Full Name
    dolichyl-phosphate N-acetylglucosaminephosphotransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:2995
    See related
    Ensembl:ENSG00000172269 MIM:191350; Vega:OTTHUMG00000153533
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPT; ALG7; DGPT; G1PT; UAGT; UGAT; CDG1J; CMS13; DPAGT; CDG-Ij; CMSTA2; DPAGT2; D11S366
    Summary
    The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 9.9), urinary bladder (RPKM 8.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See DPAGT1 in Genome Data Viewer
    Location:
    11q23.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (119096503..119102075, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118967213..118973124, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene hydroxymethylbilane synthase Neighboring gene H2A histone family member X Neighboring gene uncharacterized LOC107984397 Neighboring gene C2CD2 like Neighboring gene histone H4 transcription factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    UDP-N-acetylglucosamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    dolichol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    dolichol-linked oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dolichol-linked oligosaccharide biosynthetic process TAS
    Traceable Author Statement
    more info
     
    dolichyl diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein complex oligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    integral component of endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
    Names
    GlcNAc-1-P transferase 1
    N-acetylglucosamine-1-phosphate transferase
    UDP-GlcNAc:dolichyl-phosphate N-acetylglucosaminephosphotransferase
    UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
    dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P tra
    dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
    dolichyl-phosphate alpha-N-acetylglucosaminyltransferase
    NP_001373.2
    XP_005271479.1
    XP_011540950.1
    XP_016872782.1
    XP_016872783.1
    XP_016872784.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008918.1 RefSeqGene

      Range
      5001..10573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382.3NP_001373.2  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

      See identical proteins and their annotated locations for NP_001373.2

      Status: REVIEWED

      Source sequence(s)
      AA833740, BC000325, DA023424
      Consensus CDS
      CCDS8411.1
      UniProtKB/Swiss-Prot
      Q9H3H5
      UniProtKB/TrEMBL
      A0A024R3H8
      Related
      ENSP00000346142.4, OTTHUMP00000204052, ENST00000354202.8, OTTHUMT00000331522
      Conserved Domains (1) summary
      cd06855
      Location:29317
      GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

      Range
      119096503..119102075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017293.2XP_016872782.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X3

      UniProtKB/Swiss-Prot
      Q9H3H5
    2. XM_011542648.2XP_011540950.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X2

      Conserved Domains (1) summary
      cd06855
      Location:1210
      GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...
    3. XM_017017294.2XP_016872783.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X4

    4. XM_005271422.3XP_005271479.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X1

      Conserved Domains (1) summary
      cd06855
      Location:29317
      GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...
    5. XM_017017295.1XP_016872784.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X5

    RNA

    1. XR_947801.2 RNA Sequence

      Related
      ENST00000414373.5
    2. XR_001747785.2 RNA Sequence

      Related
      ENST00000640747.1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_203316.1: Suppressed sequence

      Description
      NM_203316.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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