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    Lepr leptin receptor [ Mus musculus (house mouse) ]

    Gene ID: 16847, updated on 22-May-2022

    Summary

    Official Symbol
    Leprprovided by MGI
    Official Full Name
    leptin receptorprovided by MGI
    Primary source
    MGI:MGI:104993
    See related
    Ensembl:ENSMUSG00000057722 AllianceGenome:MGI:104993
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    db; Obr; obl; Leprb; Modb1; LEPROT; OB-RGRP; diabetes; obese-like
    Summary
    Enables leptin receptor activity. Involved in several processes, including energy homeostasis; leptin-mediated signaling pathway; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including glial cell proliferation; glycogen metabolic process; and negative regulation of gluconeogenesis. Predicted to be located in extracellular space and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb segment; and skeleton. Used to study non-alcoholic fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 5.0), placenta adult (RPKM 3.3) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lepr in Genome Data Viewer
    Location:
    4 C6; 4 46.96 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (101574393..101676375)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (101717137..101815352)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (101390012..101487959)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C6 Neighboring gene predicted gene, 36012 Neighboring gene leptin receptor overlapping transcript Neighboring gene PRAME like 17 Neighboring gene predicted gene, 52666

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC105189

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables leptin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables leptin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bone growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cholesterol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glycogen metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in leptin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in leptin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in leptin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of hydrolase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of locomotor rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to leptin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sexual reproduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    leptin receptor
    Names
    B219
    LEP-R
    OB receptor
    leptin receptor gene-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122899.2NP_001116371.1  leptin receptor isoform 3 precursor

      See identical proteins and their annotated locations for NP_001116371.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 3' exon, as compared to variant 1. The resultign isoform (3) has a different and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AL929373
      Consensus CDS
      CCDS51239.1
      UniProtKB/Swiss-Prot
      P48356
      UniProtKB/TrEMBL
      Q3US58, Q640Q2
      Related
      ENSMUSP00000102534.3, ENSMUST00000106921.9
      Conserved Domains (3) summary
      smart00060
      Location:737818
      FN3; Fibronectin type 3 domain
      cd00063
      Location:236328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:331418
      Lep_receptor_Ig; Ig-like C2-type domain
    2. NM_010704.2NP_034834.1  leptin receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_034834.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks the 3' exon but has an alternate 3' segment, as compared to variant 1. The resulting isoform (2) has a different and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK143989, CN692760
      Consensus CDS
      CCDS18397.1
      UniProtKB/Swiss-Prot
      P48356
      UniProtKB/TrEMBL
      Q3UNU8
      Related
      ENSMUSP00000099838.4, ENSMUST00000102777.10
      Conserved Domains (3) summary
      smart00060
      Location:737818
      FN3; Fibronectin type 3 domain
      cd00063
      Location:236328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:331418
      Lep_receptor_Ig; Ig-like C2-type domain
    3. NM_146146.3NP_666258.2  leptin receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_666258.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL929373
      Consensus CDS
      CCDS51240.1
      UniProtKB/Swiss-Prot
      P48356
      Related
      ENSMUSP00000037385.4, ENSMUST00000037552.10
      Conserved Domains (3) summary
      smart00060
      Location:737818
      FN3; Fibronectin type 3 domain
      cd00063
      Location:236328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:331418
      Lep_receptor_Ig; Ig-like C2-type domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      101574393..101676375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163750.1XP_036019643.1  leptin receptor isoform X1

      Conserved Domains (4) summary
      smart00060
      Location:738819
      FN3; Fibronectin type 3 domain
      cd00063
      Location:237329
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:328419
      Lep_receptor_Ig; Ig-like C2-type domain
      pfam18589
      Location:430532
      ObR_Ig; Obesity receptor immunoglobulin like domain
    2. XM_036163752.1XP_036019645.1  leptin receptor isoform X3

      Conserved Domains (4) summary
      smart00060
      Location:738819
      FN3; Fibronectin type 3 domain
      cd00063
      Location:237329
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:328419
      Lep_receptor_Ig; Ig-like C2-type domain
      pfam18589
      Location:430532
      ObR_Ig; Obesity receptor immunoglobulin like domain
    3. XM_036163751.1XP_036019644.1  leptin receptor isoform X2

      Conserved Domains (4) summary
      smart00060
      Location:738819
      FN3; Fibronectin type 3 domain
      cd00063
      Location:237329
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:328419
      Lep_receptor_Ig; Ig-like C2-type domain
      pfam18589
      Location:430532
      ObR_Ig; Obesity receptor immunoglobulin like domain