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    Lepr leptin receptor [ Mus musculus (house mouse) ]

    Gene ID: 16847, updated on 9-Oct-2018

    Summary

    Official Symbol
    Leprprovided by MGI
    Official Full Name
    leptin receptorprovided by MGI
    Primary source
    MGI:MGI:104993
    See related
    Ensembl:ENSMUSG00000057722 Vega:OTTMUSG00000008454
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    db; Obr; obl; Leprb; Modb1; LEPROT; OB-RGRP; diabetes; obese-like
    Expression
    Broad expression in bladder adult (RPKM 5.0), placenta adult (RPKM 3.3) and 18 other tissues See more
    Orthologs

    Genomic context

    See Lepr in Genome Data Viewer
    Location:
    4 C6; 4 46.96 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (101717134..101815354)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (101390012..101487959)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C6 Neighboring gene predicted gene, 36012 Neighboring gene leptin receptor overlapping transcript Neighboring gene RIKEN cDNA B020004J07 gene Neighboring gene growth factor receptor bound protein 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • AMPK signaling pathway, organism-specific biosystem (from KEGG)
      AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • AMPK signaling pathway, conserved biosystem (from KEGG)
      AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
      Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
      Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Leptin Insulin Overlap, organism-specific biosystem (from WikiPathways)
      Leptin Insulin Overlap, organism-specific biosystemOverlap of cellular insulin and leptin signaling
    • Leptin and adiponectin, organism-specific biosystem (from WikiPathways)
      Leptin and adiponectin, organism-specific biosystemProposed mechanism by which leptin and adiponectin stimulate fatty acid oxidation. Adapted from fig 1 in [http://www.ncbi.nlm.nih.gov/pubmed/16497175 Dyck et al.].
    • Mus musculus biological processes, organism-specific biosystem (from REACTOME)
      Mus musculus biological processes, organism-specific biosystemCertain mouse pathways have been fully manually curated in Reactome in order to support the manual inference of well-conserved but less well-studied human pathways. These pathways include Circadian...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by Leptin, organism-specific biosystem (from REACTOME)
      Signaling by Leptin, organism-specific biosystemLeptin, a circulating adipokine, and its receptor Lepr control food intake and energy balance (recently reviewed in Wauman and Tavernier 2011, Bjorbaek 2009, Morris and Rui 2009, Myers et al. 2008). ...
    • Signaling by Leptin, organism-specific biosystem (from REACTOME)
      Signaling by Leptin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC105189

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    leptin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    bone growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leptin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    leptin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leptin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of hydrolase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of locomotor rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    response to leptin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sexual reproduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    leptin receptor
    Names
    B219
    LEP-R
    OB receptor
    leptin receptor gene-related protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122899.1NP_001116371.1  leptin receptor isoform 3 precursor

      See identical proteins and their annotated locations for NP_001116371.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 3' exon, as compared to variant 1. The resultign isoform (3) has a different and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK140785, BC082551, CJ319649, CN692760, U42467
      Consensus CDS
      CCDS51239.1
      UniProtKB/Swiss-Prot
      P48356
      UniProtKB/TrEMBL
      Q3US58, Q640Q2
      Related
      ENSMUSP00000102534.2, OTTMUSP00000008797, ENSMUST00000106921.8, OTTMUST00000019186
      Conserved Domains (3) summary
      smart00060
      Location:737818
      FN3; Fibronectin type 3 domain
      cd00063
      Location:236328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:331418
      Lep_receptor_Ig; Ig-like C2-type domain
    2. NM_010704.2NP_034834.1  leptin receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_034834.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks the 3' exon but has an alternate 3' segment, as compared to variant 1. The resulting isoform (2) has a different and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK143989, CN692760
      Consensus CDS
      CCDS18397.1
      UniProtKB/Swiss-Prot
      P48356
      UniProtKB/TrEMBL
      Q3UNU8
      Related
      ENSMUSP00000099838.3, OTTMUSP00000008795, ENSMUST00000102777.9, OTTMUST00000019184
      Conserved Domains (3) summary
      smart00060
      Location:737818
      FN3; Fibronectin type 3 domain
      cd00063
      Location:236328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:331418
      Lep_receptor_Ig; Ig-like C2-type domain
    3. NM_146146.2NP_666258.2  leptin receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_666258.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      CN692760, U46135
      Consensus CDS
      CCDS51240.1
      UniProtKB/Swiss-Prot
      P48356
      Related
      ENSMUSP00000037385.3, OTTMUSP00000008794, ENSMUST00000037552.9, OTTMUST00000019183
      Conserved Domains (3) summary
      smart00060
      Location:737818
      FN3; Fibronectin type 3 domain
      cd00063
      Location:236328
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:331418
      Lep_receptor_Ig; Ig-like C2-type domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      101717134..101815354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320002.1XP_017175491.1  leptin receptor isoform X1

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