Format

Send to:

Choose Destination
    • Showing Current items.

    Lep leptin [ Mus musculus (house mouse) ]

    Gene ID: 16846, updated on 14-Sep-2021

    Summary

    Official Symbol
    Lepprovided by MGI
    Official Full Name
    leptinprovided by MGI
    Primary source
    MGI:MGI:104663
    See related
    Ensembl:ENSMUSG00000059201
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ob; obese
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 267.7), genital fat pad adult (RPKM 183.5) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lep in Genome Data Viewer
    Location:
    6 A3.3; 6 12.3 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29060220..29073875)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29060221..29073876)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (29010221..29023876)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118567373 Neighboring gene microRNA 129-1 Neighboring gene long noncoding RNA upstream of leptin Neighboring gene Lep proximal promoter region Neighboring gene predicted gene, 25589 Neighboring gene RNA binding motif protein 28

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
     
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables leptin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptide hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in activation of protein kinase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in activation of protein kinase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adipose tissue development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in adult feeding behavior IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within bile acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in bone growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bone mineralization involved in bone maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to leptin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within central nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cholesterol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within eating behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within elastin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in energy reserve metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in energy reserve metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fatty acid beta-oxidation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in fatty acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glucose homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycerol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hormone metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within insulin secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in intestinal absorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leptin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in leptin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of appetite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of appetite by leptin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of appetite by leptin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cartilage development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glucagon secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glutamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ovulation from ovarian follicle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in placenta development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of developmental growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fat cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hepatic stellate cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-12 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of myeloid cell differentiation IDA
    Inferred from Direct Assay
    more info
     
    involved_in positive regulation of p38MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of brown fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of catalytic activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of fat cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of intestinal cholesterol absorption IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of lipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of lipoprotein lipid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of natural killer cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of natural killer cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of nitric-oxide synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of steroid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to dietary excess IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within response to dietary excess IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to dietary excess ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to insulin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within response to insulin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sexual reproduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sexual reproduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tyrosine phosphorylation of STAT protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in tyrosine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    leptin
    Names
    obesity factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008493.3NP_032519.1  leptin precursor

      See identical proteins and their annotated locations for NP_032519.1

      Status: VALIDATED

      Source sequence(s)
      AK030984
      Consensus CDS
      CCDS19955.1
      UniProtKB/Swiss-Prot
      P41160
      UniProtKB/TrEMBL
      Q544U0
      Related
      ENSMUSP00000067046.6, ENSMUST00000069789.12
      Conserved Domains (1) summary
      pfam02024
      Location:26167
      Leptin; Leptin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      29060220..29073875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center