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    Klf2 Kruppel-like factor 2 (lung) [ Mus musculus (house mouse) ]

    Gene ID: 16598, updated on 18-Sep-2018

    Summary

    Official Symbol
    Klf2provided by MGI
    Official Full Name
    Kruppel-like factor 2 (lung)provided by MGI
    Primary source
    MGI:MGI:1342772
    See related
    Ensembl:ENSMUSG00000055148 Vega:OTTMUSG00000022542
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lklf
    Expression
    Biased expression in spleen adult (RPKM 143.5), lung adult (RPKM 107.7) and 14 other tissues See more
    Orthologs

    Genomic context

    See Klf2 in Genome Data Viewer
    Location:
    8; 8 B3.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (72319062..72321654)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (74842961..74845553)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40505 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene Neighboring gene epidermal growth factor receptor pathway substrate 15-like 1 Neighboring gene predicted gene, 46043 Neighboring gene calreticulin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Apelin signaling pathway, organism-specific biosystem (from KEGG)
      Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
    • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
    • White fat cell differentiation, organism-specific biosystem (from WikiPathways)
      White fat cell differentiation, organism-specific biosystemThe transcription factors involved in white fat cell differentiation are shown, specifically their pattern of activity from the preadipocyte to the adipocyte (fat cells) stage. Adipose tissue, compos...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to fluid shear stress ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to laminar fluid shear stress ISO
    Inferred from Sequence Orthology
    more info
     
    cellular stress response to acid chemical ISO
    Inferred from Sequence Orthology
    more info
     
    erythrocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    erythrocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression, epigenetic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    type I pneumocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Krueppel-like factor 2
    Names
    lung krueppel-like factor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008452.2NP_032478.2  Krueppel-like factor 2

      See identical proteins and their annotated locations for NP_032478.2

      Status: VALIDATED

      Source sequence(s)
      AK131962, BF023555
      Consensus CDS
      CCDS22412.1
      UniProtKB/Swiss-Prot
      Q60843
      UniProtKB/TrEMBL
      Q3V293
      Related
      ENSMUSP00000064823.7, OTTMUSP00000025717, ENSMUST00000067912.7, OTTMUST00000053998
      Conserved Domains (4) summary
      COG5048
      Location:276353
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:273295
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:271295
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:317342
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      72319062..72321654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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