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    DAP death associated protein [ Homo sapiens (human) ]

    Gene ID: 1611, updated on 23-May-2018
    Official Symbol
    DAPprovided by HGNC
    Official Full Name
    death associated proteinprovided by HGNC
    Primary source
    HGNC:HGNC:2672
    See related
    Ensembl:ENSG00000112977 MIM:600954; Vega:OTTHUMG00000131041
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
    Expression
    Ubiquitous expression in thyroid (RPKM 62.5), urinary bladder (RPKM 56.2) and 25 other tissues See more
    Orthologs
    See DAP in Genome Data Viewer
    Location:
    5p15.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (10679230..10761275, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (10679342..10761387, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 33B Neighboring gene intersectin 1 (SH3 domain protein) pseudogene Neighboring gene uncharacterized LOC105374652 Neighboring gene uncharacterized CTD-2154B17.1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC99796

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    death domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    death domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to amino acid starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Preferred Names
    death-associated protein 1
    Names
    DAP-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011546.1 RefSeqGene

      Range
      5001..87046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001291963.1NP_001278892.1  death-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001278892.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC002726, BI823002, DC395850
      Consensus CDS
      CCDS77997.1
      UniProtKB/Swiss-Prot
      P51397
      UniProtKB/TrEMBL
      B4DQ75
      Related
      ENSP00000394163.2, OTTHUMP00000221331, ENST00000432074.2, OTTHUMT00000367388
      Conserved Domains (1) summary
      pfam15228
      Location:12179
      DAP; Death-associated protein
    2. NM_004394.2NP_004385.1  death-associated protein 1 isoform 2

      See identical proteins and their annotated locations for NP_004385.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional exon in the coding region, which causes a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC002726, BP265421, DC395850
      Consensus CDS
      CCDS3880.1
      UniProtKB/Swiss-Prot
      P51397
      Related
      ENSP00000230895.6, OTTHUMP00000161670, ENST00000230895.10, OTTHUMT00000253687
      Conserved Domains (1) summary
      pfam15228
      Location:12102
      DAP; Death-associated protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

      Range
      10679230..10761275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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