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    DAO D-amino acid oxidase [ Homo sapiens (human) ]

    Gene ID: 1610, updated on 3-Oct-2018

    Summary

    Official Symbol
    DAOprovided by HGNC
    Official Full Name
    D-amino acid oxidaseprovided by HGNC
    Primary source
    HGNC:HGNC:2671
    See related
    Ensembl:ENSG00000110887 MIM:124050; Vega:OTTHUMG00000169360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DAAO; OXDA; DAMOX
    Summary
    This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in kidney (RPKM 37.6) and liver (RPKM 29.1) See more
    Orthologs

    Genomic context

    See DAO in Genome Data Viewer
    Location:
    12q24.11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (108880030..108901043)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (109273806..109294710)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929204 Neighboring gene slingshot protein phosphatase 1 Neighboring gene microRNA 619 Neighboring gene SV2 related protein Neighboring gene RNA, U6 small nuclear 361, pseudogene Neighboring gene uncharacterized LOC105378256

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC35381

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    D-amino-acid oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    D-amino-acid oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    D-amino-acid oxidase activity TAS
    Traceable Author Statement
    more info
     
    FAD binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cofactor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cofactor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    D-alanine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    D-alanine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    D-amino acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    D-serine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    D-serine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular nitrogen compound metabolic process TAS
    Traceable Author Statement
    more info
     
    dopamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    proline catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein targeting to peroxisome TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    colocalizes_with mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peroxisomal matrix TAS
    Traceable Author Statement
    more info
     
    peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    D-amino-acid oxidase
    NP_001908.3
    XP_005268749.1
    XP_011536306.1
    XP_011536307.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023236.1 RefSeqGene

      Range
      5001..25854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001917.4NP_001908.3  D-amino-acid oxidase

      See identical proteins and their annotated locations for NP_001908.3

      Status: REVIEWED

      Source sequence(s)
      BC029057, BM932083, DA085245
      Consensus CDS
      CCDS9122.1
      UniProtKB/Swiss-Prot
      P14920
      UniProtKB/TrEMBL
      A0A024RBI1
      Related
      ENSP00000228476.3, OTTHUMP00000240887, ENST00000228476.7, OTTHUMT00000403682
      Conserved Domains (1) summary
      pfam01266
      Location:2329
      DAO; FAD dependent oxidoreductase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      108880030..108901043
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268692.4XP_005268749.1  D-amino-acid oxidase isoform X2

      Related
      ENSP00000446853.1, OTTHUMP00000240886, ENST00000551281.5
      Conserved Domains (1) summary
      pfam01266
      Location:2307
      DAO; FAD dependent oxidoreductase
    2. XM_011538005.2XP_011536307.1  D-amino-acid oxidase isoform X1

      See identical proteins and their annotated locations for XP_011536307.1

      UniProtKB/Swiss-Prot
      P14920
      UniProtKB/TrEMBL
      A0A024RBI1
      Conserved Domains (1) summary
      pfam01266
      Location:2329
      DAO; FAD dependent oxidoreductase
    3. XM_011538004.2XP_011536306.1  D-amino-acid oxidase isoform X1

      See identical proteins and their annotated locations for XP_011536306.1

      UniProtKB/Swiss-Prot
      P14920
      UniProtKB/TrEMBL
      A0A024RBI1
      Conserved Domains (1) summary
      pfam01266
      Location:2329
      DAO; FAD dependent oxidoreductase
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