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    Ighg1 immunoglobulin heavy constant gamma 1 (G1m marker) [ Mus musculus (house mouse) ]

    Gene ID: 16017, updated on 8-Dec-2022

    Summary

    Official Symbol
    Ighg1provided by MGI
    Official Full Name
    immunoglobulin heavy constant gamma 1 (G1m marker)provided by MGI
    Primary source
    MGI:MGI:96446
    See related
    IMGT/GENE-DB:IGHG1; AllianceGenome:MGI:96446
    Gene type
    other
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IgG1; Igh-4; VH7183
    Summary
    Enables antigen binding activity and immunoglobulin receptor binding activity. Acts upstream of or within several processes, including antibody-dependent cellular cytotoxicity; phagocytosis; and positive regulation of immune response. Located in external side of plasma membrane and extracellular space. Part of immunoglobulin complex, circulating. Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)); IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)); and IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See Ighg1 in Genome Data Viewer
    Location:
    12 F1; 12 62.1 cM
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (113290161..113294143, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (113326541..113330523, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA40 Neighboring gene immunoglobulin heavy constant gamma 2B Neighboring gene immunoglobulin heavy chain complex Neighboring gene FUS interacting protein (serine-arginine rich) 1 pseudogene Neighboring gene Immunoglobulin heavy constant gamma 3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Other Names

    • immunoglobulin heavy chain 4 (serum IgG1)
    • immunoglobulin heavy chain V region

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Fc-gamma receptor I complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables antigen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables immunoglobulin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within antibacterial humoral response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within antibody-dependent cellular cytotoxicity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within complement activation, classical pathway IDA
    Inferred from Direct Assay
    more info
     
    acts_upstream_of_or_within defense response to bacterium IDA
    Inferred from Direct Assay
    more info
     
    acts_upstream_of_or_within humoral immune response mediated by circulating immunoglobulin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within immunoglobulin mediated immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phagocytosis, engulfment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within phagocytosis, recognition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of type I hypersensitivity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of type IIa hypersensitivity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of IgG immunoglobulin complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of immunoglobulin complex, circulating IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_005838.1 

      Range
      78945..82927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      113290161..113294143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)