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    Igf2r insulin-like growth factor 2 receptor [ Mus musculus (house mouse) ]

    Gene ID: 16004, updated on 18-Sep-2018

    Summary

    Official Symbol
    Igf2rprovided by MGI
    Official Full Name
    insulin-like growth factor 2 receptorprovided by MGI
    Primary source
    MGI:MGI:96435
    See related
    Ensembl:ENSMUSG00000023830 Vega:OTTMUSG00000034915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD222; CI-MPR; Mpr300; AI661837; M6P/IGF2R
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 34.0), placenta adult (RPKM 24.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Igf2r in Genome Data Viewer
    Location:
    17 A1; 17 8.64 cM
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (12682406..12769706, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (12875272..12962572, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 (organic cation transporter), member 2 Neighboring gene solute carrier family 22 (organic cation transporter), member 1 Neighboring gene antisense Igf2r RNA Neighboring gene RAN GTPase activating protein 1 pseudogene Neighboring gene RAN GTPase activating protein 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein alpha-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    insulin-like growth factor II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    insulin-like growth factor II binding ISO
    Inferred from Sequence Orthology
    more info
     
    insulin-like growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    insulin-like growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kringle domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mannose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mannose binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphoprotein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    retinoic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    retinoic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    liver development ISO
    Inferred from Sequence Orthology
    more info
     
    lysosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    post-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to retinoic acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin coat ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear envelope lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    trans-Golgi network transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    cation-independent mannose-6-phosphate receptor
    Names
    300 kDa mannose 6-phosphate receptor
    CI Man-6-P receptor
    IGF-II receptor
    IGF-II/CI-MPR
    M6P/IGF2 receptor
    M6PR
    MPR 300
    cation-independent MPR
    insulin-like growth factor II receptor
    mannose-6-phosphate receptor, cation independent

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010515.2NP_034645.2  cation-independent mannose-6-phosphate receptor precursor

      See identical proteins and their annotated locations for NP_034645.2

      Status: VALIDATED

      Source sequence(s)
      AC116804, AC167817, AK053045, BB865604, BP757292, BQ900123, CA324933, CD545656, CF167933, CK639250, CN461279, CN530622
      Consensus CDS
      CCDS37436.1
      UniProtKB/Swiss-Prot
      Q07113
      UniProtKB/TrEMBL
      Q8C6V9
      Related
      ENSMUSP00000024599.7, OTTMUSP00000048420, ENSMUST00000024599.13, OTTMUST00000088766
      Conserved Domains (3) summary
      cd00062
      Location:18901935
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      pfam00878
      Location:10241171
      CIMR; Cation-independent mannose-6-phosphate receptor repeat
      pfam09451
      Location:335467
      ATG27; Autophagy-related protein 27

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      12682406..12769706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 UNKNOWN

    Genomic

    1. NT_097336.1 Reference GRCm38.p4 UNKNOWN

      Range
      97811..136198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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