Igf2r insulin-like growth factor 2 receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Igf2rprovided by MGI
Official Full Name: insulin-like growth factor 2 receptorprovided by MGI
Primary source: MGI:MGI:96435
See related: Ensembl:ENSMUSG00000023830 Vega:OTTMUSG00000034915
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD222; CI-MPR; Mpr300; AI661837; M6P/IGF2R
Expression: Ubiquitous expression in limb E14.5 (RPKM 34.0), placenta adult (RPKM 24.7) and 28 other tissues See more
Orthologs: human all

Genomic context

Location:: 17 A1; 17 8.64 cM

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
106	current	GRCm38.p4 (GCF_000001635.24)	17	NC_000083.6 (12682406..12769706, complement)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	17	NC_000083.5 (12875272..12962572, complement)

Chromosome 17 - NC_000083.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

After 6 weeks of environmental tobacco smoke exposure, the Sirt-1 protein level was decreased and cardiac autophagy was increased in C57BL mice. Furthermore, the IGF2R cardiac hypertrophy signaling pathway was also triggered, although cardiac apoptosis and hypertrophy were not induced.
Title: Environmental tobacco smoke increases autophagic effects but decreases longevity associated with Sirt-1 protein expression in young C57BL mice hearts.
Selective M6PR down-regulation has a critical role in CD8(+) T cell survival.
Title: Differential expression of mannose-6-phosphate receptor regulates T cell contraction.
Expression of imprinted gene Igf2r was unregulated in haploid androgenetic/gynogenetic blastocysts.
Title: Analysis of imprinted gene expression and implantation in haploid androgenetic mouse embryos.
that an elevation in IGF-II receptor levels can influence the expression profiles of transcripts as well as proteins that are involved in AD pathogenesis.
Title: Overexpression of the IGF-II/M6P receptor in mouse fibroblast cell lines differentially alters expression profiles of genes involved in Alzheimer's disease-related pathology.
DNA methylation changes were noted in the Igf2r gene during chronic cystitis in a murine model.
Title: Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse model.
Airn expression is both necessary and sufficient to silence Igf2r throughout embryonic stem cell differentiation.
Title: Imprinted Igf2r silencing depends on continuous Airn lncRNA expression and is not restricted to a developmental window.
The results excluded a role for spliced and unspliced Airn lncRNA products and for Airn nuclear size and location in silencing Igf2r. Instead, silencing only required Airn transcriptional overlap of the Igf2r promoter, which interferes with RNA polymerase II recruitment in the absence of repressive chromatin.
Title: Airn transcriptional overlap, but not its lncRNA products, induces imprinted Igf2r silencing.
mannose 6-phosphate/IGF2R knock-down in receptor-positive mouse hepatocytes causes increased cathepsin secretion as well as enhanced cell motility and invasiveness
Title: M6P/IGF2R modulates the invasiveness of liver cells via its capacity to bind mannose 6-phosphate residues.
enhanced CI-MPR expression might improve the efficacy of enzyme replacement therapy in Pompe disease through enhancing receptor-mediated uptake of GAA.
Title: Enhanced efficacy of enzyme replacement therapy in Pompe disease through mannose-6-phosphate receptor expression in skeletal muscle.
The interaction of sM6P/IGF2R with Plg may be an important regulatory mechanism to inhibit migration of cells using the uPA/uPAR system.
Title: Soluble M6P/IGF2R released by TACE controls angiogenesis via blocking plasminogen activation.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation

Pathways from BioSystems

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Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Clathrin derived vesicle budding, organism-specific biosystem (from REACTOME)
Clathrin derived vesicle budding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
Clathrin-mediated endocytosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Endocytosis, organism-specific biosystem (from KEGG)
Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Endocytosis, conserved biosystem (from KEGG)
Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Golgi Associated Vesicle Biogenesis, organism-specific biosystem (from REACTOME)
Golgi Associated Vesicle Biogenesis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Lysosome, organism-specific biosystem (from KEGG)
Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
Lysosome, conserved biosystem (from KEGG)
Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
Membrane Trafficking, organism-specific biosystem (from REACTOME)
Membrane Trafficking, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Neutrophil degranulation, organism-specific biosystem (from REACTOME)
Neutrophil degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K/Akt/mTOR signaling pathway, organism-specific biosystem (from LIPID MAPS)
PI3K/Akt/mTOR signaling pathway, organism-specific biosystem
PI3K/Akt/mTOR signaling pathway
Retrograde transport at the Trans-Golgi-Network, organism-specific biosystem (from REACTOME)
Retrograde transport at the Trans-Golgi-Network, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
Vesicle-mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
trans-Golgi Network Vesicle Budding, organism-specific biosystem (from REACTOME)
trans-Golgi Network Vesicle Budding, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237576

Igf2r (e-PCR), detects polymorphism
- UniSTS:470559

25.mHAa3f1.seq (e-PCR)
- UniSTS:123708

Igf2r (e-PCR), detects polymorphism
- UniSTS:516449

Igf2r (e-PCR), detects polymorphism
- UniSTS:143483

Igf2r (e-PCR), detects polymorphism
- UniSTS:143484

Igf2r (e-PCR), detects polymorphism
- UniSTS:143485

Airn (e-PCR), detects polymorphism
- UniSTS:532130

Airn (e-PCR), detects polymorphism
- UniSTS:532131

Igf2r (e-PCR), detects polymorphism
- UniSTS:532140

Igf2r (e-PCR), detects polymorphism
- UniSTS:532141

Igf2r (e-PCR), detects polymorphism
- UniSTS:516549

PMC136958P1 (e-PCR)
- UniSTS:270810

PMC136958P2 (e-PCR)
- UniSTS:270811

Igf2r (e-PCR), detects polymorphism
- UniSTS:259555

AI661837 (e-PCR)
- UniSTS:186086

Igf2r (e-PCR), detects polymorphism
- UniSTS:516605

Homology

Homologs of the Igf2r gene: The Igf2r gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 240 organisms have orthologs with human gene Igf2r
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
G-protein alpha-subunit binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enzyme binding	ISO Inferred from Sequence Orthology more info
identical protein binding	ISO Inferred from Sequence Orthology more info
insulin-like growth factor II binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
insulin-like growth factor II binding	ISO Inferred from Sequence Orthology more info
insulin-like growth factor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
insulin-like growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
kringle domain binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
mannose binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
mannose binding	IDA Inferred from Direct Assay more info	PubMed
phosphoprotein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
phosphoprotein binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
retinoic acid binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
retinoic acid binding	ISO Inferred from Sequence Orthology more info
signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
liver development	ISO Inferred from Sequence Orthology more info
lysosomal transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
post-Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
response to retinoic acid	IBA Inferred from Biological aspect of Ancestor more info	PubMed
response to retinoic acid	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
Golgi apparatus	ISO Inferred from Sequence Orthology more info
cell surface	ISO Inferred from Sequence Orthology more info
clathrin coat	ISO Inferred from Sequence Orthology more info
clathrin-coated vesicle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
early endosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
early endosome	ISO Inferred from Sequence Orthology more info
endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
endocytic vesicle	ISO Inferred from Sequence Orthology more info
endosome	ISO Inferred from Sequence Orthology more info	PubMed
extracellular space	ISO Inferred from Sequence Orthology more info
integral component of membrane	IEA Inferred from Electronic Annotation more info
late endosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
late endosome	ISO Inferred from Sequence Orthology more info
lysosome	IEA Inferred from Electronic Annotation more info
membrane	IDA Inferred from Direct Assay more info	PubMed
nuclear envelope lumen	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nuclear envelope lumen	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
plasma membrane	ISO Inferred from Sequence Orthology more info
trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info	PubMed
trans-Golgi network	ISO Inferred from Sequence Orthology more info
colocalizes_with trans-Golgi network	ISO Inferred from Sequence Orthology more info
trans-Golgi network transport vesicle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
trans-Golgi network transport vesicle	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: cation-independent mannose-6-phosphate receptor

Names: 300 kDa mannose 6-phosphate receptor; CI Man-6-P receptor; IGF-II receptor; IGF-II/CI-MPR; M6P/IGF2 receptor; M6PR; MPR 300; cation-independent MPR; insulin-like growth factor II receptor; mannose-6-phosphate receptor, cation independent

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010515.2 → NP_034645.2 cation-independent mannose-6-phosphate receptor precursor

See identical proteins and their annotated locations for NP_034645.2

Status: VALIDATED

Source sequence(s)

AC116804, AC167817, AK053045, BB865604, BP757292, BQ900123, CA324933, CD545656, CF167933, CK639250, CN461279, CN530622

Consensus CDS

CCDS37436.1

UniProtKB/Swiss-Prot

Q07113

UniProtKB/TrEMBL

Q8C6V9

Related

ENSMUSP00000024599.7, OTTMUSP00000048420, ENSMUST00000024599.13, OTTMUST00000088766

Conserved Domains (3) summary

cd00062
Location:1890 → 1935

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...

pfam00878
Location:1024 → 1171

CIMR; Cation-independent mannose-6-phosphate receptor repeat

pfam09451
Location:335 → 467

ATG27; Autophagy-related protein 27