Format

Send to:

Choose Destination
    • Showing Current items.

    GRK3 G protein-coupled receptor kinase 3 [ Homo sapiens (human) ]

    Gene ID: 157, updated on 23-Nov-2021

    Summary

    Official Symbol
    GRK3provided by HGNC
    Official Full Name
    G protein-coupled receptor kinase 3provided by HGNC
    Primary source
    HGNC:HGNC:290
    See related
    Ensembl:ENSG00000100077 MIM:109636
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BARK2; ADRBK2
    Summary
    The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in fat (RPKM 17.4), spleen (RPKM 8.7) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GRK3 in Genome Data Viewer
    Location:
    22q12.1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (25564675..25729294)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (25960642..26125261)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene conserved acetylation island sequence 2 enhancer Neighboring gene crystallin beta B2 pseudogene 1 Neighboring gene microRNA 6817 Neighboring gene GRK3 antisense RNA 1 Neighboring gene uncharacterized LOC105372964 Neighboring gene YES1 pseudogene 1 Neighboring gene RNA, 5S ribosomal pseudogene 494 Neighboring gene Sharpr-MPRA regulatory region 14204 Neighboring gene Sharpr-MPRA regulatory region 2919 Neighboring gene myosin XVIIIB

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables G protein-coupled receptor kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables beta-adrenergic receptor kinase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in desensitization of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    beta-adrenergic receptor kinase 2
    Names
    adrenergic, beta, receptor kinase 2
    beta-ARK-2
    NP_001349707.1
    NP_005151.2
    XP_011528277.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362778.2NP_001349707.1  beta-adrenergic receptor kinase 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL022329, BC029563
      Conserved Domains (3) summary
      cd01240
      Location:440557
      PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
      cd05633
      Location:72417
      STKc_GRK3; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3
      cl02565
      Location:173
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    2. NM_005160.4NP_005151.2  beta-adrenergic receptor kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_005151.2

      Status: REVIEWED

      Source sequence(s)
      AL022329, BC036797, BC063545, BX387339
      Consensus CDS
      CCDS13832.1
      UniProtKB/Swiss-Prot
      P35626
      UniProtKB/TrEMBL
      A0A024R1D8, Q8N433
      Related
      ENSP00000317578.4, ENST00000324198.11
      Conserved Domains (3) summary
      cd08747
      Location:30186
      RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
      cd01240
      Location:553670
      PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
      cd05633
      Location:185530
      STKc_GRK3; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

      Range
      25564675..25729294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529975.2XP_011528277.1  beta-adrenergic receptor kinase 2 isoform X2

      Conserved Domains (5) summary
      cd01240
      Location:388505
      PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
      cd05633
      Location:20365
      STKc_GRK3; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3
      pfam00069
      Location:26288
      Pkinase; Protein kinase domain
      pfam00169
      Location:395484
      PH; PH domain
      cl02565
      Location:121
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RNA

    1. XR_001755175.1 RNA Sequence

    2. XR_937823.1 RNA Sequence

    Support Center