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    CTSB cathepsin B [ Homo sapiens (human) ]

    Gene ID: 1508, updated on 6-Jan-2019

    Summary

    Official Symbol
    CTSBprovided by HGNC
    Official Full Name
    cathepsin Bprovided by HGNC
    Primary source
    HGNC:HGNC:2527
    See related
    Ensembl:ENSG00000164733 MIM:116810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APPS; CPSB; RECEUP
    Summary
    This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]
    Expression
    Broad expression in thyroid (RPKM 602.1), appendix (RPKM 198.7) and 21 other tissues See more
    Orthologs

    Genomic context

    See CTSB in Genome Data Viewer
    Location:
    8p23.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (11842524..11868150, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (11700033..11725646, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379243 Neighboring gene SUB1 homolog, transcriptional regulator pseudogene 1 Neighboring gene farnesyl-diphosphate farnesyltransferase 1 Neighboring gene olfactory receptor family 7 subfamily E member 158 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 161 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Keratolytic winter erythema
    MedGen: C0406756 OMIM: 148370 GeneReviews: Not available
    not available

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated (2012-02-08)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated (2012-02-08)

    ClinGen Genome Curation Page

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection upregulates cathepsin B, cystatin B, and cystatin C in the frontal white matter of patients with HIV-Associated Neurocognitive Disorders PubMed
    HIV-1 infection in macrophages decreases Cathepsin B and MMP9 interactions PubMed
    HIV-1 infection upregulates cathepsin B (CTSB) in microglia and CHME-5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of cathepsin B (CTSB) in human B cells PubMed
    env HIV-1 gp120-treated vaginal epithelial cells show downregulation of cathepsin B (CTSB) expression as compared to untreated control PubMed
    Pr55(Gag) gag Macrophages and HEK293T cells deficient in cathepsin B (CTSB) fail to release HIV-1 Gag pseudoparticles into the extracellular environment PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of cathepsin B (CTSB) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing and presentation, organism-specific biosystem (from KEGG)
      Antigen processing and presentation, organism-specific biosystem
      Antigen processing and presentation
    • Antigen processing and presentation, conserved biosystem (from KEGG)
      Antigen processing and presentation, conserved biosystem
      Antigen processing and presentation
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Assembly of collagen fibrils and other multimeric structures, organism-specific biosystem (from REACTOME)
      Assembly of collagen fibrils and other multimeric structures, organism-specific biosystemCollagen trimers in triple-helical form, referred to as procollagen or collagen molecules, are exported from the ER and trafficked through the Golgi network before secretion into the extracellular sp...
    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Collagen degradation, organism-specific biosystem (from REACTOME)
      Collagen degradation, organism-specific biosystemCollagen fibril diameter and spatial organisation are dependent on the species, tissue type and stage of development (Parry 1988). The lengths of collagen fibrils in mature tissues are largely unknow...
    • Collagen formation, organism-specific biosystem (from REACTOME)
      Collagen formation, organism-specific biosystemCollagen is a family of at least 29 structural proteins derived from over 40 human genes (Myllyharju & Kivirikko 2004). It is the main component of connective tissue, and the most abundant protein in...
    • Degradation of the extracellular matrix, organism-specific biosystem (from REACTOME)
      Degradation of the extracellular matrix, organism-specific biosystemMatrix metalloproteinases (MMPs), previously referred to as matrixins because of their role in degradation of the extracellular matrix (ECM), are zinc and calcium dependent proteases belonging to the...
    • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
      Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Lysosome, organism-specific biosystem (from KEGG)
      Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
    • Lysosome, conserved biosystem (from KEGG)
      Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
    • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
      MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    • Renin secretion, organism-specific biosystem (from KEGG)
      Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Renin secretion, conserved biosystem (from KEGG)
      Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
      Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
    • Trafficking and processing of endosomal TLR, organism-specific biosystem (from REACTOME)
      Trafficking and processing of endosomal TLR, organism-specific biosystemMammalian TLR3, TLR7, TLR8, TLR9 are endosomal receptors that sense nucleic acids that have been released from endocytosed/phagocytosed bacteria, viruses or parasites. These TLRs have a ligand-recogn...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    collagen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cysteine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    proteoglycan binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    serine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    cellular response to thyroid hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    collagen catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen catabolic process TAS
    Traceable Author Statement
    more info
     
    decidualization IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis involved in cellular protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteolysis involved in cellular protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    collagen-containing extracellular matrix HDA PubMed 
    colocalizes_with collagen-containing extracellular matrix HDA PubMed 
    endolysosome lumen TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cathepsin B
    Names
    APP secretase
    amyloid precursor protein secretase
    cathepsin B1
    cysteine protease
    epididymis secretory sperm binding protein
    NP_001304166.1
    NP_001899.1
    NP_680090.1
    NP_680091.1
    NP_680092.1
    NP_680093.1
    XP_006716307.1
    XP_006716308.1
    XP_011542114.1
    XP_016868586.1
    XP_016868588.1
    XP_016868589.1
    XP_016868590.1
    XP_024302839.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009217.2 RefSeqGene

      Range
      4988..30614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001317237.1NP_001304166.1  cathepsin B isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks an exon in its 5' coding region and uses an alternate translation start site compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, and lacks a predicted signal peptide compared to isoform 1.
      Source sequence(s)
      AA516096, AC069185, AK130184, BX647765, DC386022
      UniProtKB/TrEMBL
      Q5HYG5
      Conserved Domains (1) summary
      cd02620
      Location:25204
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    2. NM_001908.5NP_001899.1  cathepsin B isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_001899.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (1). Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AA516096, AC069185, AK130184, DC386022
      Consensus CDS
      CCDS5986.1
      UniProtKB/Swiss-Prot
      P07858
      UniProtKB/TrEMBL
      A0A024R374
      Related
      ENSP00000345672.5, ENST00000353047.10
      Conserved Domains (2) summary
      cd02620
      Location:81328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:2665
      Propeptide_C1; Peptidase family C1 propeptide
    3. NM_147780.3NP_680090.1  cathepsin B isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_680090.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AA516096, AC069185, AK130184, BG770805, DC386022
      Consensus CDS
      CCDS5986.1
      UniProtKB/Swiss-Prot
      P07858
      UniProtKB/TrEMBL
      A0A024R374
      Conserved Domains (2) summary
      cd02620
      Location:81328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:2665
      Propeptide_C1; Peptidase family C1 propeptide
    4. NM_147781.3NP_680091.1  cathepsin B isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_680091.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AA516096, AC069185, AK130184, AL543654, DC386022
      Consensus CDS
      CCDS5986.1
      UniProtKB/Swiss-Prot
      P07858
      UniProtKB/TrEMBL
      A0A024R374
      Related
      ENSP00000342070.3, ENST00000345125.7
      Conserved Domains (2) summary
      cd02620
      Location:81328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:2665
      Propeptide_C1; Peptidase family C1 propeptide
    5. NM_147782.3NP_680092.1  cathepsin B isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_680092.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AA516096, AC069185, AK130184, BG770805, DC386022
      Consensus CDS
      CCDS5986.1
      UniProtKB/Swiss-Prot
      P07858
      UniProtKB/TrEMBL
      A0A024R374
      Related
      ENSP00000432244.1, ENST00000533455.5
      Conserved Domains (2) summary
      cd02620
      Location:81328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:2665
      Propeptide_C1; Peptidase family C1 propeptide
    6. NM_147783.3NP_680093.1  cathepsin B isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_680093.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AA516096, AC069185, AK092070, AK130184, DC386022
      Consensus CDS
      CCDS5986.1
      UniProtKB/Swiss-Prot
      P07858
      UniProtKB/TrEMBL
      A0A024R374
      Related
      ENSP00000409917.2, ENST00000453527.6
      Conserved Domains (2) summary
      cd02620
      Location:81328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:2665
      Propeptide_C1; Peptidase family C1 propeptide

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

      Range
      11842524..11868150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013097.2XP_016868586.1  cathepsin B isoform X1

      UniProtKB/Swiss-Prot
      P07858
      UniProtKB/TrEMBL
      A0A024R374
      Conserved Domains (2) summary
      cd02620
      Location:81328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:2665
      Propeptide_C1; Peptidase family C1 propeptide
    2. XM_006716244.3XP_006716307.1  cathepsin B isoform X1

      See identical proteins and their annotated locations for XP_006716307.1

      UniProtKB/Swiss-Prot
      P07858
      UniProtKB/TrEMBL
      A0A024R374
      Conserved Domains (2) summary
      cd02620
      Location:81328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:2665
      Propeptide_C1; Peptidase family C1 propeptide
    3. XM_017013100.2XP_016868589.1  cathepsin B isoform X1

      UniProtKB/Swiss-Prot
      P07858
      UniProtKB/TrEMBL
      A0A024R374
      Related
      ENSP00000434217.1, ENST00000534510.5
      Conserved Domains (2) summary
      cd02620
      Location:81328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:2665
      Propeptide_C1; Peptidase family C1 propeptide
    4. XM_017013099.2XP_016868588.1  cathepsin B isoform X1

      UniProtKB/Swiss-Prot
      P07858
      UniProtKB/TrEMBL
      A0A024R374
      Conserved Domains (2) summary
      cd02620
      Location:81328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:2665
      Propeptide_C1; Peptidase family C1 propeptide
    5. XM_011543812.3XP_011542114.1  cathepsin B isoform X1

      See identical proteins and their annotated locations for XP_011542114.1

      UniProtKB/Swiss-Prot
      P07858
      UniProtKB/TrEMBL
      A0A024R374
      Conserved Domains (2) summary
      cd02620
      Location:81328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:2665
      Propeptide_C1; Peptidase family C1 propeptide
    6. XM_024447071.1XP_024302839.1  cathepsin B isoform X1

      Conserved Domains (2) summary
      cd02620
      Location:81328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:2665
      Propeptide_C1; Peptidase family C1 propeptide
    7. XM_006716245.3XP_006716308.1  cathepsin B isoform X1

      See identical proteins and their annotated locations for XP_006716308.1

      UniProtKB/Swiss-Prot
      P07858
      UniProtKB/TrEMBL
      A0A024R374
      Conserved Domains (2) summary
      cd02620
      Location:81328
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:2665
      Propeptide_C1; Peptidase family C1 propeptide
    8. XM_017013101.2XP_016868590.1  cathepsin B isoform X2

      UniProtKB/TrEMBL
      B4DMY4
      Conserved Domains (1) summary
      cd02620
      Location:11234
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

    Reference GRCh38.p12 PATCHES

    Genomic

    1. NW_018654717.1 Reference GRCh38.p12 PATCHES

      Range
      1479909..1505569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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