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    CTNND1 catenin delta 1 [ Homo sapiens (human) ]

    Gene ID: 1500, updated on 6-Jan-2019

    Summary

    Official Symbol
    CTNND1provided by HGNC
    Official Full Name
    catenin delta 1provided by HGNC
    Primary source
    HGNC:HGNC:2515
    See related
    Ensembl:ENSG00000198561 MIM:601045
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAS; p120; BCDS2; CTNND; P120CAS; P120CTN; p120(CAS); p120(CTN)
    Summary
    This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]
    Expression
    Ubiquitous expression in esophagus (RPKM 79.1), skin (RPKM 62.3) and 24 other tissues See more
    Orthologs

    Genomic context

    See CTNND1 in Genome Data Viewer
    Location:
    11q12.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (57761762..57819180)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57520756..57586652)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene TMX2-CTNND1 readthrough (NMD candidate) Neighboring gene peptidylprolyl isomerase A pseudogene 42 Neighboring gene thioredoxin related transmembrane protein 2 Neighboring gene selenoprotein H Neighboring gene BTB domain containing 18 Neighboring gene cytochrome c oxidase subunit NDUFA4 pseudogene Neighboring gene olfactory receptor family 5 subfamily BA member 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    BLEPHAROCHEILODONTIC SYNDROME 2
    MedGen: C4540127 OMIM: 617681 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough TMX2-CTNND1

    Readthrough gene: TMX2-CTNND1, Included gene: TMX2

    Homology

    Clone Names

    • KIAA0384

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cadherin binding HDA PubMed 
    cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cadherin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    adherens junction organization TAS
    Traceable Author Statement
    more info
     
    brain development IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    entry of bacterium into host cell TAS
    Traceable Author Statement
    more info
     
    negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of postsynaptic membrane neurotransmitter receptor levels EXP
    Inferred from Experiment
    more info
    PubMed 
    regulation of postsynaptic membrane neurotransmitter receptor levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    catenin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome HDA PubMed 
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    hippocampal mossy fiber to CA3 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynaptic density, intracellular component IEA
    Inferred from Electronic Annotation
    more info
     
    presynaptic active zone cytoplasmic component IEA
    Inferred from Electronic Annotation
    more info
     
    zonula adherens IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    catenin delta-1
    Names
    cadherin-associated Src substrate
    catenin (cadherin-associated protein), delta 1
    p120 catenin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029078.1 RefSeqGene

      Range
      5001..62419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001085458.1NP_001078927.1  catenin delta-1 isoform 1ABC

      See identical proteins and their annotated locations for NP_001078927.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longest variant and it encodes the longest protein (isoform 1ABC). This variant has also been called hp120ctn-1ABC.
      Source sequence(s)
      AF062341, AI088791, BC075795, BP217375, CN431494, DB090596
      Consensus CDS
      CCDS44604.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000382004.4, ENST00000399050.8
      Conserved Domains (2) summary
      cd00020
      Location:363481
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:368393
      ARM; armadillo repeat [structural motif]
    2. NM_001085459.1NP_001078928.1  catenin delta-1 isoform 1AB

      See identical proteins and their annotated locations for NP_001078928.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment in the coding region, compared to variant 1. The resulting protein (isoform 1AB) is shorter than isoform 1ABC. This variant is also called hp120ctn-1AB.
      Source sequence(s)
      AF062328, AI088791, BC075795, BP217375, CN431494, DB090596
      Consensus CDS
      CCDS44605.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000354823.4, ENST00000361332.8
      Conserved Domains (2) summary
      cd00020
      Location:363481
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:368393
      ARM; armadillo repeat [structural motif]
    3. NM_001085460.1NP_001078929.1  catenin delta-1 isoform 1A

      See identical proteins and their annotated locations for NP_001078929.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses a different splice site in the 5' UTR and lacks two alternate in-frame segments in the coding region, compared to variant 1. This variant shares the alternate name of hp120ctn-1A with variants 5 and 6. Variants 4, 5, and 6 encode the same protein (isoform 1A), which is shorter than isoform 1ABC.
      Source sequence(s)
      AF062324, AI088791, AL698868, BC075795, BP217375, CN431494
      Consensus CDS
      CCDS44606.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000351527.6, ENST00000358694.10
      Conserved Domains (2) summary
      cd00020
      Location:363481
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:368393
      ARM; armadillo repeat [structural motif]
    4. NM_001085461.1NP_001078930.1  catenin delta-1 isoform 1A

      See identical proteins and their annotated locations for NP_001078930.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame segments in the coding region, compared to variant 1. This variant shares the alternate name of hp120ctn-1A with variants 4 and 6. Variants 4, 5, and 6 encode the same protein (isoform 1A), which is shorter than isoform 1ABC.
      Source sequence(s)
      AF062339, AI088791, BC075795, BP217375, CN431494, DB090596
      Consensus CDS
      CCDS44606.1
      UniProtKB/Swiss-Prot
      O60716
      Conserved Domains (2) summary
      cd00020
      Location:363481
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:368393
      ARM; armadillo repeat [structural motif]
    5. NM_001085462.1NP_001078931.1  catenin delta-1 isoform 1A

      See identical proteins and their annotated locations for NP_001078931.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses a different splice site in the 5' UTR, lacks an alternate segment in the 5' UTR, and lacks two alternate in-frame segments in the coding region, compared to variant 1. This variant shares the alternate name of hp120ctn-1A with variants 4 and 5. Variants 4, 5, and 6 encode the same protein (isoform 1A), which is shorter than isoform 1ABC.
      Source sequence(s)
      AF062343, AI088791, BC075795, BP217375, CN431494
      Consensus CDS
      CCDS44606.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000413586.2, ENST00000428599.6
      Conserved Domains (2) summary
      cd00020
      Location:363481
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:368393
      ARM; armadillo repeat [structural motif]
    6. NM_001085463.1NP_001078932.1  catenin delta-1 isoform 3ABC

      See identical proteins and their annotated locations for NP_001078932.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has multiple differences and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 3ABC) has a shorter N-terminus, compared to isoform 1ABC. This variant is also called hp120ctn-3ABC.
      Source sequence(s)
      AF062323, AI088791, BC075795, BP217375, CN431494
      Consensus CDS
      CCDS44608.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000403518.2, ENST00000415361.6
      Conserved Domains (2) summary
      cd00020
      Location:262380
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:267292
      ARM; armadillo repeat [structural motif]
    7. NM_001085464.1NP_001078933.1  catenin delta-1 isoform 3AB

      See identical proteins and their annotated locations for NP_001078933.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) has multiple differences and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 3AB) has a shorter N-terminus, compared to isoform 1ABC. This variant is also called hp120ctn-3AB.
      Source sequence(s)
      AF062338, AI088791, BC075795, BP217375, CN431494
      Consensus CDS
      CCDS53633.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000437327.1, ENST00000530094.5
      Conserved Domains (2) summary
      cd00020
      Location:262380
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:267292
      ARM; armadillo repeat [structural motif]
    8. NM_001085465.1NP_001078934.1  catenin delta-1 isoform 3B

      See identical proteins and their annotated locations for NP_001078934.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) has multiple differences and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 3B) is shorter when it is compared to isoform 1ABC. This variant is also called hp120ctn-3B.
      Source sequence(s)
      AF062332, AI088791, BC075795, BP217375, CN431494
      Consensus CDS
      CCDS53634.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000434949.1, ENST00000532787.5
      Conserved Domains (2) summary
      cd00020
      Location:262380
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:267292
      ARM; armadillo repeat [structural motif]
    9. NM_001085466.1NP_001078935.1  catenin delta-1 isoform 3AC

      See identical proteins and their annotated locations for NP_001078935.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) has multiple differences, compared to variant 1. The resulting protein (isoform 3AC) is shorter than isoform 1ABC. This variant is also called hp120ctn-3AC.
      Source sequence(s)
      AF062337, AI088791, BC075795, BP217375, CN431494
      Consensus CDS
      CCDS53632.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000435266.1, ENST00000528232.5
      Conserved Domains (2) summary
      cd00020
      Location:262380
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:267292
      ARM; armadillo repeat [structural motif]
    10. NM_001085467.1NP_001078936.1  catenin delta-1 isoform 3A

      See identical proteins and their annotated locations for NP_001078936.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks multiple alternate segments in the 5' UTR and in the coding region, compared to variant 1. This variant shares the alternate name of hp120ctn-3A with variants 12 and 13. Variants 11, 12, and 13 encode the same protein (isoform 3A), which is shorter than isoform 1ABC.
      Source sequence(s)
      AF062334, AI088791, BC075795, BP217375, CN431494, DB090596
      Consensus CDS
      CCDS44609.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000409930.2, ENST00000426142.6
      Conserved Domains (2) summary
      cd00020
      Location:262380
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:267292
      ARM; armadillo repeat [structural motif]
    11. NM_001085468.1NP_001078937.1  catenin delta-1 isoform 3A

      See identical proteins and their annotated locations for NP_001078937.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) lacks multiple alternate segments in the 5' UTR and in the coding region, compared to variant 1. This variant shares the alternate name of hp120ctn-3A with variants 11 and 13. Variants 11, 12, and 13 encode the same protein (isoform 3A), which is shorter than isoform 1ABC.
      Source sequence(s)
      AF062335, AI088791, BC075795, BP217375, CN431494
      Consensus CDS
      CCDS44609.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000437156.1, ENST00000529986.5
      Conserved Domains (2) summary
      cd00020
      Location:262380
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:267292
      ARM; armadillo repeat [structural motif]
    12. NM_001085469.1NP_001078938.1  catenin delta-1 isoform 3A

      See identical proteins and their annotated locations for NP_001078938.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) lacks multiple alternate segments in the 5' UTR and in the coding region, compared to variant 1. This variant shares the alternate name of hp120ctn-3A with variants 11 and 12. Variants 11, 12, and 13 encode the same protein (isoform 3A), which is shorter than isoform 1ABC.
      Source sequence(s)
      AF062336, AI088791, BC075795, BP217375, CN431494
      Consensus CDS
      CCDS44609.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000434017.1, ENST00000532245.5
      Conserved Domains (2) summary
      cd00020
      Location:262380
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:267292
      ARM; armadillo repeat [structural motif]
    13. NM_001206883.1NP_001193812.1  catenin delta-1 isoform 2ABC

      See identical proteins and their annotated locations for NP_001193812.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2ABC) has a shorter N-terminus than isoform 1ABC.
      Source sequence(s)
      AF062319, AI079200, AP001931, BP217375
      Consensus CDS
      CCDS55763.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000433276.1, ENST00000532844.5
      Conserved Domains (2) summary
      cd00020
      Location:309427
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:314339
      ARM; armadillo repeat [structural motif]
    14. NM_001206884.1NP_001193813.1  catenin delta-1 isoform 2AC

      See identical proteins and their annotated locations for NP_001193813.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (2AC) is shorter than isoform 1ABC.
      Source sequence(s)
      AF062320, AI079200, AP001931, BP217375
      Consensus CDS
      CCDS55764.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000436744.1, ENST00000530748.5
      Conserved Domains (2) summary
      cd00020
      Location:309427
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:314339
      ARM; armadillo repeat [structural motif]
    15. NM_001206885.1NP_001193814.1  catenin delta-1 isoform 1AC

      See identical proteins and their annotated locations for NP_001193814.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) lacks an in-frame exon in the 3_ coding region, compared to variant 1. This results in a shorter protein (isoform 1AC), compared to isoform 1ABC).
      Source sequence(s)
      AF062321, AI079200, AP001931, BP217375
      Consensus CDS
      CCDS73290.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000354907.5, ENST00000361796.9
      Conserved Domains (2) summary
      cd00020
      Location:363481
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:368393
      ARM; armadillo repeat [structural motif]
    16. NM_001206886.1NP_001193815.1  catenin delta-1 isoform 2AB

      See identical proteins and their annotated locations for NP_001193815.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (2AB) is shorter than isoform 1ABC.
      Source sequence(s)
      AF062322, AI079200, AP001931, BP217375
      Consensus CDS
      CCDS55765.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000433334.1, ENST00000526357.5
      Conserved Domains (2) summary
      cd00020
      Location:309427
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:314339
      ARM; armadillo repeat [structural motif]
    17. NM_001206887.1NP_001193816.1  catenin delta-1 isoform 2B

      See identical proteins and their annotated locations for NP_001193816.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (2B) is shorter than isoform 1ABC.
      Source sequence(s)
      AF062325, AI079200, AP001931, BP217375
      Consensus CDS
      CCDS55767.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000435494.1, ENST00000529873.5
      Conserved Domains (2) summary
      cd00020
      Location:309427
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:314339
      ARM; armadillo repeat [structural motif]
    18. NM_001206888.1NP_001193817.1  catenin delta-1 isoform 2A

      See identical proteins and their annotated locations for NP_001193817.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (2A) is shorter than isoform 1ABC.
      Source sequence(s)
      AF062327, AI079200, AP001931, BP217375
      Consensus CDS
      CCDS55766.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000432243.1, ENST00000528621.5
      Conserved Domains (2) summary
      cd00020
      Location:309427
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:314339
      ARM; armadillo repeat [structural motif]
    19. NM_001206889.1NP_001193818.1  catenin delta-1 isoform 2A

      See identical proteins and their annotated locations for NP_001193818.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (2A) is shorter than isoform 1ABC.
      Source sequence(s)
      AF062329, AI079200, AP001931, BP217375
      Consensus CDS
      CCDS55766.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000435379.1, ENST00000532649.5
      Conserved Domains (2) summary
      cd00020
      Location:309427
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:314339
      ARM; armadillo repeat [structural motif]
    20. NM_001206890.1NP_001193819.1  catenin delta-1 isoform 3A

      See identical proteins and their annotated locations for NP_001193819.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (3A) is shorter than isoform 1ABC.
      Source sequence(s)
      AF062330, AI079200, AP001931, BP217375
      Consensus CDS
      CCDS44609.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000432075.1, ENST00000532463.5
      Conserved Domains (2) summary
      cd00020
      Location:262380
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:267292
      ARM; armadillo repeat [structural motif]
    21. NM_001206891.1NP_001193820.1  catenin delta-1 isoform 2A

      See identical proteins and their annotated locations for NP_001193820.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (2A) is shorter than isoform 1ABC.
      Source sequence(s)
      AF062331, AI079200, AP001931, BP217375
      Consensus CDS
      CCDS55766.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000436323.1, ENST00000529526.5
      Conserved Domains (2) summary
      cd00020
      Location:309427
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:314339
      ARM; armadillo repeat [structural motif]
    22. NM_001331.2NP_001322.1  catenin delta-1 isoform 1B

      See identical proteins and their annotated locations for NP_001322.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame segments in the coding region, compared to variant 1. The encoded protein (isoform 1B) is shorter than isoform 1ABC. Another name for this variant is hp120ctn-1B.
      Source sequence(s)
      AF062317, AI088791, BC075795, BP217375, CN431494, DB090596
      Consensus CDS
      CCDS44607.1
      UniProtKB/Swiss-Prot
      O60716
      Related
      ENSP00000354785.6, ENST00000361391.10
      Conserved Domains (2) summary
      cd00020
      Location:363481
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:368393
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

      Range
      57761762..57819180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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