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    Gata6 GATA binding protein 6 [ Mus musculus (house mouse) ]

    Gene ID: 14465, updated on 14-Jan-2019

    Summary

    Official Symbol
    Gata6provided by MGI
    Official Full Name
    GATA binding protein 6provided by MGI
    Primary source
    MGI:MGI:107516
    See related
    Ensembl:ENSMUSG00000005836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GATA-6; AA410133
    Expression
    Biased expression in adrenal adult (RPKM 88.8), ovary adult (RPKM 57.8) and 10 other tissues See more
    Orthologs

    Genomic context

    See Gata6 in Genome Data Viewer
    Location:
    18 A1; 18 5.63 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (11052510..11085636)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (11052508..11085633)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35814 Neighboring gene RIKEN cDNA 9130001E16 gene Neighboring gene PHD finger protein 14 pseudogene Neighboring gene RIKEN cDNA 1010001N08 gene Neighboring gene predicted gene, 35918 Neighboring gene retinoblastoma binding protein 8, endonuclease

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II repressing transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enhancer sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Clara cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    animal organ formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac muscle cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cardiac muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cardiac muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac muscle hypertrophy in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac muscle tissue development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cardiac vascular smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to BMP stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to gonadotropin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    endodermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endodermal cell fate determination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intestinal epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung saccule development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of pri-miRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transforming growth factor beta1 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transforming growth factor beta2 production ISO
    Inferred from Sequence Orthology
    more info
     
    outflow tract septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pancreatic A cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phospholipid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac muscle cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cardiac muscle myoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardioblast differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to estrogen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to growth factor ISO
    Inferred from Sequence Orthology
    more info
     
    smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    tube morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    type B pancreatic cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    type II pneumocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor GATA-6
    Names
    GATA-binding factor 6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010258.3NP_034388.2  transcription factor GATA-6

      See identical proteins and their annotated locations for NP_034388.2

      Status: VALIDATED

      Source sequence(s)
      AI120546, AK142381, BB042635, BY084328
      Consensus CDS
      CCDS29059.1
      UniProtKB/Swiss-Prot
      Q61169
      Related
      ENSMUSP00000041774.7, ENSMUST00000047762.9
      Conserved Domains (3) summary
      smart00401
      Location:435482
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:437488
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:147371
      GATA-N; GATA-type transcription activator, N-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      11052510..11085636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317834.1XP_017173323.1  transcription factor GATA-6 isoform X1

      Conserved Domains (3) summary
      smart00401
      Location:435482
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:437488
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:147371
      GATA-N; GATA-type transcription activator, N-terminal
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