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    OR51E1 olfactory receptor family 51 subfamily E member 1 [ Homo sapiens (human) ]

    Gene ID: 143503, updated on 23-May-2018
    Official Symbol
    OR51E1provided by HGNC
    Official Full Name
    olfactory receptor family 51 subfamily E member 1provided by HGNC
    Primary source
    HGNC:HGNC:15194
    See related
    Ensembl:ENSG00000180785 MIM:611267; Vega:OTTHUMG00000157024
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    POGR; DGPCR; PSGR2; D-GPCR; GPR136; GPR164; OR51E1P; OR52A3P
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in prostate (RPKM 7.2), fat (RPKM 4.9) and 8 other tissues See more
    Orthologs
    See OR51E1 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (4643926..4655488)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (4665156..4676718)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 68 Neighboring gene olfactory receptor family 51 subfamily D member 1 Neighboring gene olfactory receptor family 51 subfamily A member 9 pseudogene Neighboring gene uncharacterized LOC105376528

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • Olfactory Signaling Pathway, organism-specific biosystem (from REACTOME)
      Olfactory Signaling Pathway, organism-specific biosystemMammalian Olfactory Receptor (OR) genes were discoved in rats by Linda Buck and Richard Axel, who predicted that odorants would be detected by a large family of G protein-coupled receptors (GPCRs) th...
    • Olfactory transduction, organism-specific biosystem (from KEGG)
      Olfactory transduction, organism-specific biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
    • Olfactory transduction, conserved biosystem (from KEGG)
      Olfactory transduction, conserved biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Markers

    Homology

    Clone Names

    • FLJ13581, MGC24137

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    olfactory receptor 51E1
    Names
    Dresden-G-protein-coupled receptor
    G-protein coupled receptor 164
    olfactory receptor 52A3
    olfactory receptor OR11-15
    olfactory receptor, family 51, subfamily E, member 1 pseudogene
    olfactory receptor, family 52, subfamily A, member 3 pseudogene
    prostate overexpressed G protein-coupled receptor
    prostate-specific G protein-coupled receptor 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152430.3NP_689643.2  olfactory receptor 51E1

      See identical proteins and their annotated locations for NP_689643.2

      Status: VALIDATED

      Source sequence(s)
      AC090719, AL833127, BC022401
      Consensus CDS
      CCDS31358.2
      UniProtKB/Swiss-Prot
      Q8TCB6
      UniProtKB/TrEMBL
      A0A126GVF8
      Related
      ENSP00000380155.5, OTTHUMP00000211320, ENST00000396952.5, OTTHUMT00000347136
      Conserved Domains (2) summary
      pfam00001
      Location:44294
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:34309
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

      Range
      4643926..4655488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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