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    Erg ETS transcription factor [ Mus musculus (house mouse) ]

    Gene ID: 13876, updated on 12-Aug-2018

    Summary

    Official Symbol
    Ergprovided by MGI
    Official Full Name
    ETS transcription factorprovided by MGI
    Primary source
    MGI:MGI:95415
    See related
    Ensembl:ENSMUSG00000040732 Vega:OTTMUSG00000026424
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D030036I24Rik
    Expression
    Broad expression in lung adult (RPKM 16.0), limb E14.5 (RPKM 8.4) and 21 other tissues See more
    Orthologs

    Genomic context

    See Erg in Genome Data Viewer
    Location:
    16 C4; 16 56.04 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (95359169..95586593, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (95581811..95751972, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31641 Neighboring gene predicted gene, 31754 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 15 Neighboring gene predicted gene, 31845 Neighboring gene predicted gene, 31901

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocardial cushion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocardial cushion to mesenchymal transition involved in heart valve formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT positive regulation of blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcriptional regulator ERG
    Names
    avian erythroblastosis virus E-26 (v-ets) oncogene related

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302152.1NP_001289081.1  transcriptional regulator ERG isoform 2

      See identical proteins and their annotated locations for NP_001289081.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a longer 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AC154691, AK050922, AK078113, BP753340
      Consensus CDS
      CCDS79495.1
      UniProtKB/Swiss-Prot
      P81270
      UniProtKB/TrEMBL
      B7ZND4
      Related
      OTTMUSP00000058140, OTTMUST00000103972
      Conserved Domains (2) summary
      smart00413
      Location:293376
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )
    2. NM_001302153.1NP_001289082.1  transcriptional regulator ERG isoform 3

      See identical proteins and their annotated locations for NP_001289082.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a downstream alternate 5'-terminal exon which reflects use of an alternate promoter supported by epigenetic data, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC154691, AK078113, AK142379, BB639043, BP753340
      Consensus CDS
      CCDS79493.1
      UniProtKB/Swiss-Prot
      P81270
      UniProtKB/TrEMBL
      Q3UQJ4
      Related
      ENSMUSP00000135568.2, OTTMUSP00000032560, ENSMUST00000176345.8, OTTMUST00000065348
      Conserved Domains (2) summary
      smart00413
      Location:310393
      ETS; erythroblast transformation specific domain
      cl15755
      Location:115198
      SAM_superfamily; SAM (Sterile alpha motif )
    3. NM_001302154.1NP_001289083.1  transcriptional regulator ERG isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses a downstream alternate 5'-terminal exon which reflects use of an alternate promoter supported by epigenetic data, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC154691, AK078113, BB639043, BP753340
      Consensus CDS
      CCDS79492.1
      UniProtKB/Swiss-Prot
      P81270
      UniProtKB/TrEMBL
      D3YU51
      Related
      ENSMUSP00000114072.2, OTTMUSP00000032562, ENSMUST00000122199.8, OTTMUST00000065350
      Conserved Domains (2) summary
      smart00413
      Location:287370
      ETS; erythroblast transformation specific domain
      cl15755
      Location:115198
      SAM_superfamily; SAM (Sterile alpha motif )
    4. NM_001302179.1NP_001289108.1  transcriptional regulator ERG isoform 5

      See identical proteins and their annotated locations for NP_001289108.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (5) is shorter compared to isoform 1.
      Source sequence(s)
      AC154691, AK050922, AK078113, BP753340
      Consensus CDS
      CCDS79496.1
      UniProtKB/Swiss-Prot
      P81270
      Related
      OTTMUSP00000032563, OTTMUST00000065351
      Conserved Domains (2) summary
      smart00413
      Location:294377
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )
    5. NM_001302183.1NP_001289112.1  transcriptional regulator ERG isoform 6

      See identical proteins and their annotated locations for NP_001289112.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (6) is shorter compared to isoform 1.
      Source sequence(s)
      AC154691, AK050922, AK078113, BP753340
      Consensus CDS
      CCDS79494.1
      UniProtKB/Swiss-Prot
      P81270
      UniProtKB/TrEMBL
      E9PY05
      Related
      ENSMUSP00000132766.1, OTTMUSP00000058141, ENSMUST00000171646.8, OTTMUST00000103973
      Conserved Domains (2) summary
      smart00413
      Location:270353
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )
    6. NM_133659.3NP_598420.1  transcriptional regulator ERG isoform 1

      See identical proteins and their annotated locations for NP_598420.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC154691, AK050922, AK078113, BP753340
      Consensus CDS
      CCDS37411.1
      UniProtKB/Swiss-Prot
      P81270
      Related
      ENSMUSP00000109479.3, OTTMUSP00000058139, ENSMUST00000113848.9, OTTMUST00000103971
      Conserved Domains (2) summary
      smart00413
      Location:317400
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      95359169..95586593 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522895.2XP_006522958.1  transcriptional regulator ERG isoform X1

      See identical proteins and their annotated locations for XP_006522958.1

      UniProtKB/Swiss-Prot
      P81270
      Conserved Domains (2) summary
      smart00413
      Location:317400
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )
    2. XM_006522903.3XP_006522966.1  transcriptional regulator ERG isoform X4

      See identical proteins and their annotated locations for XP_006522966.1

      UniProtKB/TrEMBL
      E9PY05
      Conserved Domains (2) summary
      smart00413
      Location:270353
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )
    3. XM_006522899.3XP_006522962.1  transcriptional regulator ERG isoform X2

      See identical proteins and their annotated locations for XP_006522962.1

      UniProtKB/Swiss-Prot
      P81270
      Conserved Domains (2) summary
      smart00413
      Location:294377
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )
    4. XM_006522894.3XP_006522957.1  transcriptional regulator ERG isoform X1

      See identical proteins and their annotated locations for XP_006522957.1

      UniProtKB/Swiss-Prot
      P81270
      Conserved Domains (2) summary
      smart00413
      Location:317400
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )
    5. XM_006522900.2XP_006522963.1  transcriptional regulator ERG isoform X3

      See identical proteins and their annotated locations for XP_006522963.1

      UniProtKB/Swiss-Prot
      P81270
      UniProtKB/TrEMBL
      B7ZND4
      Related
      ENSMUSP00000113723.3, ENSMUST00000121809.9
      Conserved Domains (2) summary
      smart00413
      Location:293376
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )
    6. XM_006522896.3XP_006522959.1  transcriptional regulator ERG isoform X1

      See identical proteins and their annotated locations for XP_006522959.1

      UniProtKB/Swiss-Prot
      P81270
      Conserved Domains (2) summary
      smart00413
      Location:317400
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )
    7. XM_006522904.3XP_006522967.1  transcriptional regulator ERG isoform X5

      See identical proteins and their annotated locations for XP_006522967.1

      Related
      OTTMUSP00000058142, OTTMUST00000103974
      Conserved Domains (2) summary
      smart00413
      Location:278361
      ETS; erythroblast transformation specific domain
      cl15755
      Location:83166
      SAM_superfamily; SAM (Sterile alpha motif )

    Reference GRCm38.p4 129S6/SvEvTac

    Genomic

    1. NT_039634.4 Reference GRCm38.p4 129S6/SvEvTac

      Range
      1230676..1456981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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