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    Erg ETS transcription factor [ Mus musculus (house mouse) ]

    Gene ID: 13876, updated on 21-Oct-2021

    Summary

    Official Symbol
    Ergprovided by MGI
    Official Full Name
    ETS transcription factorprovided by MGI
    Primary source
    MGI:MGI:95415
    See related
    Ensembl:ENSMUSG00000040732
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D030036I24Rik
    Expression
    Broad expression in lung adult (RPKM 16.0), limb E14.5 (RPKM 8.4) and 21 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Erg in Genome Data Viewer
    Location:
    16 C4; 16 56.04 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (95160028..95387452, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (95359169..95586600, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (95581811..95751972, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31641 Neighboring gene predicted gene, 31754 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 15 Neighboring gene predicted gene, 31845 Neighboring gene predicted gene, 31901

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcriptional regulator ERG
    Names
    avian erythroblastosis virus E-26 (v-ets) oncogene related

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302152.1NP_001289081.1  transcriptional regulator ERG isoform 2

      See identical proteins and their annotated locations for NP_001289081.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a longer 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AC154691, AK050922, AK078113, BP753340
      Consensus CDS
      CCDS79495.1
      UniProtKB/Swiss-Prot
      P81270
      UniProtKB/TrEMBL
      B7ZND4
      Related
      ENSMUSP00000156926.2, ENSMUST00000233269.2
      Conserved Domains (2) summary
      smart00413
      Location:293376
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )
    2. NM_001302153.1NP_001289082.1  transcriptional regulator ERG isoform 3

      See identical proteins and their annotated locations for NP_001289082.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a downstream alternate 5'-terminal exon which reflects use of an alternate promoter supported by epigenetic data, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC154691, AK078113, AK142379, BB639043, BP753340
      Consensus CDS
      CCDS79493.1
      UniProtKB/Swiss-Prot
      P81270
      UniProtKB/TrEMBL
      Q3UQJ4
      Related
      ENSMUSP00000114072.4, ENSMUST00000122199.10
      Conserved Domains (2) summary
      smart00413
      Location:310393
      ETS; erythroblast transformation specific domain
      cl15755
      Location:115198
      SAM_superfamily; SAM (Sterile alpha motif )
    3. NM_001302154.1NP_001289083.1  transcriptional regulator ERG isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses a downstream alternate 5'-terminal exon which reflects use of an alternate promoter supported by epigenetic data, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC154691, AK078113, BB639043, BP753340
      Consensus CDS
      CCDS79492.1
      UniProtKB/Swiss-Prot
      P81270
      UniProtKB/TrEMBL
      D3YU51
      Related
      ENSMUSP00000156927.2, ENSMUST00000233664.2
      Conserved Domains (2) summary
      smart00413
      Location:287370
      ETS; erythroblast transformation specific domain
      cl15755
      Location:115198
      SAM_superfamily; SAM (Sterile alpha motif )
    4. NM_001302179.1NP_001289108.1  transcriptional regulator ERG isoform 5

      See identical proteins and their annotated locations for NP_001289108.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (5) is shorter compared to isoform 1.
      Source sequence(s)
      AC154691, AK050922, AK078113, BP753340
      Consensus CDS
      CCDS79496.1
      UniProtKB/Swiss-Prot
      P81270
      Related
      ENSMUSP00000109479.5, ENSMUST00000113848.11
      Conserved Domains (2) summary
      smart00413
      Location:294377
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )
    5. NM_001302183.1NP_001289112.1  transcriptional regulator ERG isoform 6

      See identical proteins and their annotated locations for NP_001289112.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (6) is shorter compared to isoform 1.
      Source sequence(s)
      AC154691, AK050922, AK078113, BP753340
      Consensus CDS
      CCDS79494.1
      UniProtKB/Swiss-Prot
      P81270
      UniProtKB/TrEMBL
      E9PY05
      Related
      ENSMUSP00000132766.2, ENSMUST00000171646.10
      Conserved Domains (2) summary
      smart00413
      Location:270353
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )
    6. NM_133659.3NP_598420.1  transcriptional regulator ERG isoform 1

      See identical proteins and their annotated locations for NP_598420.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC154691, AK050922, AK078113, BP753340
      Consensus CDS
      CCDS37411.1
      UniProtKB/Swiss-Prot
      P81270
      Related
      ENSMUSP00000156669.2, ENSMUST00000233881.2
      Conserved Domains (2) summary
      smart00413
      Location:317400
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      95160028..95387452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522895.3XP_006522958.1  transcriptional regulator ERG isoform X2

      See identical proteins and their annotated locations for XP_006522958.1

      UniProtKB/Swiss-Prot
      P81270
      Conserved Domains (2) summary
      smart00413
      Location:317400
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )
    2. XM_006522903.3XP_006522966.1  transcriptional regulator ERG isoform X6

      See identical proteins and their annotated locations for XP_006522966.1

      UniProtKB/TrEMBL
      E9PY05
      Conserved Domains (2) summary
      smart00413
      Location:270353
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )
    3. XM_006522900.3XP_006522963.1  transcriptional regulator ERG isoform X4

      See identical proteins and their annotated locations for XP_006522963.1

      UniProtKB/Swiss-Prot
      P81270
      UniProtKB/TrEMBL
      B7ZND4
      Conserved Domains (2) summary
      smart00413
      Location:293376
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )
    4. XM_006522899.3XP_006522962.1  transcriptional regulator ERG isoform X3

      See identical proteins and their annotated locations for XP_006522962.1

      UniProtKB/Swiss-Prot
      P81270
      Conserved Domains (2) summary
      smart00413
      Location:294377
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )
    5. XM_006522894.3XP_006522957.1  transcriptional regulator ERG isoform X2

      See identical proteins and their annotated locations for XP_006522957.1

      UniProtKB/Swiss-Prot
      P81270
      Conserved Domains (2) summary
      smart00413
      Location:317400
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )
    6. XM_006522896.5XP_006522959.1  transcriptional regulator ERG isoform X2

      See identical proteins and their annotated locations for XP_006522959.1

      UniProtKB/Swiss-Prot
      P81270
      Conserved Domains (2) summary
      smart00413
      Location:317400
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122205
      SAM_superfamily; SAM (Sterile alpha motif )
    7. XM_030248973.2XP_030104833.1  transcriptional regulator ERG isoform X7

      Conserved Domains (2) summary
      smart00413
      Location:263346
      ETS; erythroblast transformation specific domain
      cl15755
      Location:115198
      SAM_superfamily; SAM (Sterile alpha motif )
    8. XM_030248972.2XP_030104832.1  transcriptional regulator ERG isoform X5

      Related
      ENSMUSP00000113723.5, ENSMUST00000121809.11
      Conserved Domains (2) summary
      smart00413
      Location:286369
      ETS; erythroblast transformation specific domain
      cl15755
      Location:115198
      SAM_superfamily; SAM (Sterile alpha motif )
    9. XM_006522904.5XP_006522967.1  transcriptional regulator ERG isoform X8

      See identical proteins and their annotated locations for XP_006522967.1

      Related
      ENSMUSP00000135568.4, ENSMUST00000176345.10
      Conserved Domains (2) summary
      smart00413
      Location:278361
      ETS; erythroblast transformation specific domain
      cl15755
      Location:83166
      SAM_superfamily; SAM (Sterile alpha motif )
    10. XM_036159777.1XP_036015670.1  transcriptional regulator ERG isoform X1

      Conserved Domains (2) summary
      smart00413
      Location:212295
      ETS; erythroblast transformation specific domain
      cl15755
      Location:83166
      SAM_superfamily; SAM (Sterile alpha motif )
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