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    Elf3 E74-like factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 13710, updated on 8-Dec-2018

    Summary

    Official Symbol
    Elf3provided by MGI
    Official Full Name
    E74-like factor 3provided by MGI
    Primary source
    MGI:MGI:1101781
    See related
    Ensembl:ENSMUSG00000003051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESX; jen; ESE-1
    Expression
    Biased expression in colon adult (RPKM 183.3), large intestine adult (RPKM 134.0) and 7 other tissues See more
    Orthologs

    Genomic context

    See Elf3 in Genome Data Viewer
    Location:
    1; 1 E4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (135253574..135258565, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (137150151..137155049, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41955 Neighboring gene nucleosome assembly protein 1-like 1 pseudogene Neighboring gene arginyl aminopeptidase (aminopeptidase B) Neighboring gene myeloma-overexpressed gene 2 protein homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    anatomical structure morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blastocyst development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland involution IDA
    Inferred from Direct Assay
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    ETS-related transcription factor Elf-3
    Names
    elf3
    epithelial-restricted with serine box
    epithelium-restricted Ets protein ESX
    epithelium-specific Ets transcription factor 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163131.1NP_001156603.1  ETS-related transcription factor Elf-3 isoform 1

      See identical proteins and their annotated locations for NP_001156603.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC130277, BC145380
      Consensus CDS
      CCDS48372.1
      UniProtKB/Swiss-Prot
      Q3UPW2
      Related
      ENSMUSP00000003135.7, ENSMUST00000003135.13
      Conserved Domains (2) summary
      cd08537
      Location:74151
      SAM_PNT-ESE-1-like; Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators
      smart00413
      Location:292379
      ETS; erythroblast transformation specific domain
    2. NM_007921.3NP_031947.1  ETS-related transcription factor Elf-3 isoform 2

      See identical proteins and their annotated locations for NP_031947.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AC130277, BC138692
      Consensus CDS
      CCDS78689.1
      UniProtKB/Swiss-Prot
      Q3UPW2
      Related
      ENSMUSP00000139769.1, ENSMUST00000185752.1
      Conserved Domains (2) summary
      cd08537
      Location:52131
      SAM_PNT-ESE-1-like; Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators
      smart00413
      Location:272359
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      135253574..135258565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529125.1XP_006529188.1  ETS-related transcription factor Elf-3 isoform X2

      Conserved Domains (2) summary
      cd08537
      Location:126205
      SAM_PNT-ESE-1-like; Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators
      smart00413
      Location:346433
      ETS; erythroblast transformation specific domain
    2. XM_006529124.1XP_006529187.1  ETS-related transcription factor Elf-3 isoform X1

      Conserved Domains (2) summary
      cd08537
      Location:148225
      SAM_PNT-ESE-1-like; Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators
      smart00413
      Location:366453
      ETS; erythroblast transformation specific domain
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