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    CPB2 carboxypeptidase B2 [ Homo sapiens (human) ]

    Gene ID: 1361, updated on 13-Jan-2020

    Summary

    Official Symbol
    CPB2provided by HGNC
    Official Full Name
    carboxypeptidase B2provided by HGNC
    Primary source
    HGNC:HGNC:2300
    See related
    Ensembl:ENSG00000080618 MIM:603101
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPU; PCPB; TAFI
    Summary
    Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
    Expression
    Restricted expression toward liver (RPKM 288.0) See more
    Orthologs

    Genomic context

    See CPB2 in Genome Data Viewer
    Location:
    13q14.13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (46053066..46105076, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (46627201..46695318, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370191 Neighboring gene zinc finger CCCH-type containing 13 Neighboring gene CPB2 antisense RNA 1 Neighboring gene lymphocyte cytosolic protein 1 Neighboring gene RNA, 7SL, cytoplasmic 288, pseudogene Neighboring gene uncharacterized LOC105370192 Neighboring gene uncharacterized LOC107984578

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    fibrinolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    liver regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of fibrinolysis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of hepatocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of plasminogen activation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of extracellular matrix constituent secretion IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of complement activation TAS
    Traceable Author Statement
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome HDA PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    carboxypeptidase B2
    Names
    carboxypeptidase B-like protein
    carboxypeptidase B2 (plasma)
    carboxypeptidase B2 (plasma, carboxypeptidase U)
    carboxypeptidase R
    thrombin-activable fibrinolysis inhibitor
    thrombin-activatable fibrinolysis inhibitor
    NP_001265470.1
    NP_001863.3
    XP_016875882.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032893.2 RefSeqGene

      Range
      5001..56848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001278541.1NP_001265470.1  carboxypeptidase B2 isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001265470.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      AB011969, AL137141, AL157758, AU100156
      Consensus CDS
      CCDS73568.1
      UniProtKB/Swiss-Prot
      Q96IY4
      UniProtKB/TrEMBL
      A0A087WSY5
      Related
      ENSP00000400714.3, ENST00000439329.5
      Conserved Domains (2) summary
      pfam02244
      Location:33104
      Propep_M14; Carboxypeptidase activation peptide
      cl11393
      Location:119383
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    2. NM_001872.5NP_001863.3  carboxypeptidase B2 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_001863.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL137141, AL157758, BC007057
      Consensus CDS
      CCDS9401.1
      UniProtKB/Swiss-Prot
      Q96IY4
      Related
      ENSP00000181383.4, ENST00000181383.10
      Conserved Domains (2) summary
      cd06246
      Location:119420
      M14_CPB2; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B2 subgroup
      pfam02244
      Location:33104
      Propep_M14; Carboxypeptidase activation peptide

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      Range
      46053066..46105076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020393.2XP_016875882.1  carboxypeptidase B2 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_016413.3: Suppressed sequence

      Description
      NM_016413.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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