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    Gadd45a growth arrest and DNA-damage-inducible 45 alpha [ Mus musculus (house mouse) ]

    Gene ID: 13197, updated on 31-Dec-2019

    Summary

    Official Symbol
    Gadd45aprovided by MGI
    Official Full Name
    growth arrest and DNA-damage-inducible 45 alphaprovided by MGI
    Primary source
    MGI:MGI:107799
    See related
    Ensembl:ENSMUSG00000036390
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ddit1; GADD45; AA545191
    Expression
    Broad expression in ovary adult (RPKM 73.1), liver E14 (RPKM 52.4) and 24 other tissues See more
    Orthologs

    Genomic context

    See Gadd45a in Genome Data Viewer
    Location:
    6; 6 C1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (67035096..67037407, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (66985090..66987401, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), gamma 12 Neighboring gene U1 spliceosomal RNA Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene RIKEN cDNA E230016M11 gene Neighboring gene predicted gene, 29848 Neighboring gene predicted gene, 29928 Neighboring gene RIKEN cDNA A430010J10 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of MAPKKK activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of MAPKKK activity ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle arrest IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mitotic cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    growth arrest and DNA damage-inducible protein GADD45 alpha
    Names
    DDIT-1
    DNA damage-inducible transcript 1 protein
    DNA-damage-inducible transcript 1
    Gadd45alpha
    growth arrest and DNA-damage-inducible, alpha

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007836.1NP_031862.1  growth arrest and DNA damage-inducible protein GADD45 alpha

      See identical proteins and their annotated locations for NP_031862.1

      Status: VALIDATED

      Source sequence(s)
      L28177
      Consensus CDS
      CCDS20217.1
      UniProtKB/Swiss-Prot
      P48316
      UniProtKB/TrEMBL
      Q3UMH6
      Related
      ENSMUSP00000044034.6, ENSMUST00000043098.8
      Conserved Domains (1) summary
      pfam01248
      Location:21105
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p6 C57BL/6J

      Range
      67035096..67037407 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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