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    GRK7 G protein-coupled receptor kinase 7 [ Homo sapiens (human) ]

    Gene ID: 131890, updated on 21-Dec-2019

    Summary

    Official Symbol
    GRK7provided by HGNC
    Official Full Name
    G protein-coupled receptor kinase 7provided by HGNC
    Primary source
    HGNC:HGNC:17031
    See related
    Ensembl:ENSG00000114124 MIM:606987
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPRK7
    Summary
    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See GRK7 in Genome Data Viewer
    Location:
    3q23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (141763124..141818490)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (141497043..141535892)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2618 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 3 Neighboring gene ring finger protein 7 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4237 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4238

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    G protein-coupled receptor kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    rhodopsin kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of rhodopsin mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    visual perception IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    photoreceptor disc membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    rhodopsin kinase GRK7
    Names
    g protein-coupled receptor kinase GRK7
    rhodopsin kinase
    NP_631948.1
    XP_016861206.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139209.2NP_631948.1  rhodopsin kinase GRK7

      See identical proteins and their annotated locations for NP_631948.1

      Status: REVIEWED

      Source sequence(s)
      AF439409
      Consensus CDS
      CCDS3120.1
      UniProtKB/Swiss-Prot
      Q8WTQ7
      Related
      ENSP00000264952.2, ENST00000264952.2
      Conserved Domains (3) summary
      cd08749
      Location:40181
      RGS_GRK7; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 7 (GRK7)
      smart00220
      Location:195454
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05607
      Location:188474
      STKc_GRK7; Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      141763124..141818490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005717.2XP_016861206.1  rhodopsin kinase GRK7 isoform X1

      UniProtKB/Swiss-Prot
      Q8WTQ7
      Conserved Domains (3) summary
      cd08749
      Location:40181
      RGS_GRK7; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 7 (GRK7)
      smart00220
      Location:195454
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05607
      Location:188474
      STKc_GRK7; Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7
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