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    Cd55 CD55 molecule, decay accelerating factor for complement [ Mus musculus (house mouse) ]

    Gene ID: 13136, updated on 10-Jun-2018

    Summary

    Official Symbol
    Cd55provided by MGI
    Official Full Name
    CD55 molecule, decay accelerating factor for complementprovided by MGI
    Primary source
    MGI:MGI:104850
    See related
    Ensembl:ENSMUSG00000026399 Vega:OTTMUSG00000025169
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Daf; Daf1; Daf-GPI; GPI-DAF
    Summary
    This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. The encoded preproprotein undergoes post-translational processing to generate a mature polypeptide anchored to the plasma membrane via a glycosylphosphatidylinositol moiety. Erythrocytes from mice deficient in the encoded protein exhibit impaired regulation of complement activation resulting in enhanced complement deposition. Mice lacking the encoded protein exhibit enhanced susceptibility to experimentally induced myasthenia gravis. This gene is located adjacent to a closely related gene on chromosome 1. [provided by RefSeq, Nov 2015]
    Expression
    Broad expression in bladder adult (RPKM 9.5), testis adult (RPKM 5.4) and 20 other tissues See more

    Genomic context

    See Cd55 in Genome Data Viewer
    Location:
    1 E4; 1 56.89 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (130429789..130463021, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (132335606..132359317, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41951 Neighboring gene CD55 molecule, decay accelerating factor for complement B Neighboring gene predicted gene 15674 Neighboring gene predicted gene 16083 Neighboring gene zona pellucida 3 receptor Neighboring gene complement component 4 binding protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • AC111067.4

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of complement activation, classical pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    complement decay-accelerating factor, GPI-anchored
    Names
    CD55 antigen
    Cromer blood group
    GPI anchor addition signal
    complement-glycosylphosphatidylinositol
    decay accelerating factor 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010016.3NP_034146.2  complement decay-accelerating factor, GPI-anchored preproprotein

      See identical proteins and their annotated locations for NP_034146.2

      Status: REVIEWED

      Source sequence(s)
      AC111067, AK160994
      Consensus CDS
      CCDS15256.1
      UniProtKB/Swiss-Prot
      Q61475
      Related
      ENSMUSP00000027650.6, OTTMUSP00000030472, ENSMUST00000027650.12, OTTMUST00000061930
      Conserved Domains (2) summary
      cd00033
      Location:225285
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:98158
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      130429789..130463021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529116.3XP_006529179.1  complement decay-accelerating factor, GPI-anchored isoform X5

      Conserved Domains (2) summary
      cd00033
      Location:225285
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:98158
      Sushi; Sushi repeat (SCR repeat)
    2. XM_017314303.1XP_017169792.1  complement decay-accelerating factor, GPI-anchored isoform X2

      UniProtKB/Swiss-Prot
      Q61475
      Conserved Domains (2) summary
      cd00033
      Location:225285
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:98158
      Sushi; Sushi repeat (SCR repeat)
    3. XM_017314336.1XP_017169825.1  complement decay-accelerating factor, GPI-anchored isoform X4

    4. XM_006529115.3XP_006529178.1  complement decay-accelerating factor, GPI-anchored isoform X1

      Conserved Domains (2) summary
      cd00033
      Location:225285
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:98158
      Sushi; Sushi repeat (SCR repeat)
    5. XM_006529117.3XP_006529180.1  complement decay-accelerating factor, GPI-anchored isoform X3

      Conserved Domains (2) summary
      cd00033
      Location:110170
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:243
      Sushi; Sushi repeat (SCR repeat)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187021.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      125302..149149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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