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    Cd55 CD55 molecule, decay accelerating factor for complement [ Mus musculus (house mouse) ]

    Gene ID: 13136, updated on 31-Aug-2021

    Summary

    Official Symbol
    Cd55provided by MGI
    Official Full Name
    CD55 molecule, decay accelerating factor for complementprovided by MGI
    Primary source
    MGI:MGI:104850
    See related
    Ensembl:ENSMUSG00000026399
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Daf; Daf-; Daf1; GPI-; Daf-GPI; GPI-DAF
    Summary
    This gene encodes an inhibitor of both the classical and the alternative pathways of complement activation. The encoded preproprotein undergoes post-translational processing to generate a mature polypeptide anchored to the plasma membrane via a glycosylphosphatidylinositol moiety. Erythrocytes from mice deficient in the encoded protein exhibit impaired regulation of complement activation resulting in enhanced complement deposition. Mice lacking the encoded protein exhibit enhanced susceptibility to experimentally induced myasthenia gravis. This gene is located adjacent to a closely related gene on chromosome 1. [provided by RefSeq, Nov 2015]
    Expression
    Broad expression in bladder adult (RPKM 9.5), testis adult (RPKM 5.4) and 20 other tissues See more
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    Genomic context

    See Cd55 in Genome Data Viewer
    Location:
    1 E4; 1 56.89 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130357526..130392746, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130429798..130465009, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (132335606..132359317, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41951 Neighboring gene CD55 molecule, decay accelerating factor for complement B Neighboring gene CD55 molecule, opposite strand sequence Neighboring gene predicted gene 16083 Neighboring gene zona pellucida 3 receptor Neighboring gene predicted gene, 23623

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • AC111067.4

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in T cell mediated immunity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of complement activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of CD4-positive, alpha-beta T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of complement activation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of complement activation, classical pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of complement-dependent cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in regulation of lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    complement decay-accelerating factor, GPI-anchored
    Names
    CD55 antigen
    Cromer blood group
    GPI anchor addition signal
    complement-glycosylphosphatidylinositol
    decay accelerating factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010016.3NP_034146.2  complement decay-accelerating factor, GPI-anchored preproprotein

      See identical proteins and their annotated locations for NP_034146.2

      Status: REVIEWED

      Source sequence(s)
      AC111067, AK160994
      Consensus CDS
      CCDS15256.1
      UniProtKB/Swiss-Prot
      Q61475
      Related
      ENSMUSP00000027650.7, ENSMUST00000027650.13
      Conserved Domains (2) summary
      cd00033
      Location:225285
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam00084
      Location:98158
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      130357526..130392746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246237.2XP_030102097.1  complement decay-accelerating factor, GPI-anchored isoform X2

      Conserved Domains (3) summary
      pfam00802
      Location:285361
      Glycoprotein_G; Pneumovirus attachment glycoprotein G
      cd00033
      Location:3695
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:98292
      PHA02927; secreted complement-binding protein; Provisional
    2. XM_036158038.1XP_036013931.1  complement decay-accelerating factor, GPI-anchored isoform X4

      Conserved Domains (2) summary
      PHA02927
      Location:4177
      PHA02927; secreted complement-binding protein; Provisional
      NF033201
      Location:155260
      Vip_LPXTG_Lm; cell invasion LPXTG protein Vip
    3. XM_006529115.5XP_006529178.1  complement decay-accelerating factor, GPI-anchored isoform X1

      Conserved Domains (3) summary
      pfam00802
      Location:285361
      Glycoprotein_G; Pneumovirus attachment glycoprotein G
      cd00033
      Location:3695
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:98292
      PHA02927; secreted complement-binding protein; Provisional
    4. XM_006529117.5XP_006529180.1  complement decay-accelerating factor, GPI-anchored isoform X3

      Conserved Domains (2) summary
      pfam00802
      Location:170246
      Glycoprotein_G; Pneumovirus attachment glycoprotein G
      PHA02927
      Location:4177
      PHA02927; secreted complement-binding protein; Provisional
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