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    Comp cartilage oligomeric matrix protein [ Mus musculus (house mouse) ]

    Gene ID: 12845, updated on 16-Oct-2021

    Summary

    Official Symbol
    Compprovided by MGI
    Official Full Name
    cartilage oligomeric matrix proteinprovided by MGI
    Primary source
    MGI:MGI:88469
    See related
    Ensembl:ENSMUSG00000031849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TSP5
    Expression
    Biased expression in testis adult (RPKM 93.6) and limb E14.5 (RPKM 39.4) See more
    Orthologs
    NEW
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    Genomic context

    See Comp in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70826186..70834721)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70373548..70382066)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (72897447..72905965)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coatomer protein complex, subunit epsilon Neighboring gene ceramide synthase 1 Neighboring gene growth differentiation factor 1 Neighboring gene UPF1 regulator of nonsense transcripts homolog (yeast) Neighboring gene predicted gene, 51533 Neighboring gene CREB regulated transcription coactivator 1 Neighboring gene kelch-like 26

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables BMP binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables extracellular matrix structural constituent ISO
    Inferred from Sequence Orthology
    more info
     
    enables fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparan sulfate proteoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables proteoglycan binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables vitamin D binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within animal organ senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within bone growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within bone morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cartilage development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chondrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chondrocyte proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within chondrocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within collagen fibril organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within endochondral bone growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within growth plate cartilage development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within growth plate cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within limb development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in limb development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within musculoskeletal movement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of hemostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of chondrocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to unfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within tendon development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within vascular associated smooth muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within vascular associated smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cartilage oligomeric matrix protein
    Names
    thrombospondin-5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016685.2NP_057894.2  cartilage oligomeric matrix protein precursor

      See identical proteins and their annotated locations for NP_057894.2

      Status: VALIDATED

      Source sequence(s)
      AC158553, AF033530, BY328097, CJ324165
      Consensus CDS
      CCDS22367.1
      UniProtKB/Swiss-Prot
      Q9R0G6
      Related
      ENSMUSP00000003659.8, ENSMUST00000003659.9
      Conserved Domains (7) summary
      smart00179
      Location:178216
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:125160
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00001
      Location:395416
      TSP3; TSP3 repeat_short [structural motif]
      sd00002
      Location:299334
      TSP3; TSP3 repeat_long [structural motif]
      pfam02412
      Location:300334
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:544741
      TSP_C; Thrombospondin C-terminal region
      cd16077
      Location:2971
      TSP-5cc; Coiled coil region of thrombospondin-5 (TSP-5)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70826186..70834721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153742.1XP_036009635.1  cartilage oligomeric matrix protein isoform X1

      Conserved Domains (8) summary
      smart00179
      Location:178216
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:125160
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00001
      Location:395416
      TSP3; TSP3 repeat_short [structural motif]
      sd00002
      Location:299334
      TSP3; TSP3 repeat_long [structural motif]
      cd16077
      Location:2971
      TSP-5cc; Coiled coil region of thrombospondin-5 (TSP-5)
      pfam02412
      Location:299334
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:544694
      TSP_C; Thrombospondin C-terminal region
      NF033845
      Location:311542
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    2. XM_006509539.2XP_006509602.1  cartilage oligomeric matrix protein isoform X2

      Conserved Domains (6) summary
      smart00179
      Location:67105
      EGF_CA; Calcium-binding EGF-like domain
      sd00001
      Location:284305
      TSP3; TSP3 repeat_short [structural motif]
      sd00002
      Location:188223
      TSP3; TSP3 repeat_long [structural motif]
      pfam00008
      Location:1849
      EGF; EGF-like domain
      pfam02412
      Location:188223
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:433630
      TSP_C; Thrombospondin C-terminal region
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