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    Comp cartilage oligomeric matrix protein [ Mus musculus (house mouse) ]

    Gene ID: 12845, updated on 8-Dec-2018

    Summary

    Official Symbol
    Compprovided by MGI
    Official Full Name
    cartilage oligomeric matrix proteinprovided by MGI
    Primary source
    MGI:MGI:88469
    See related
    Ensembl:ENSMUSG00000031849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TSP5
    Expression
    Biased expression in testis adult (RPKM 93.6) and limb E14.5 (RPKM 39.4) See more
    Orthologs

    Genomic context

    See Comp in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (70373548..70382066)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (72897447..72905965)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene coatomer protein complex, subunit epsilon Neighboring gene ceramide synthase 1 Neighboring gene growth differentiation factor 1 Neighboring gene UPF1 regulator of nonsense transcripts homolog (yeast) Neighboring gene CREB regulated transcription coactivator 1 Neighboring gene kelch-like 26

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • ECM proteoglycans, organism-specific biosystem (from REACTOME)
      ECM proteoglycans, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
      Extracellular matrix organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
      Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    BMP binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix structural constituent ISO
    Inferred from Sequence Orthology
    more info
     
    fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    heparan sulfate proteoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    proteoglycan binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    vitamin D binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    animal organ senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cartilage development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    chondrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chondrocyte proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    chondrocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    collagen fibril organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endochondral bone growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    growth plate cartilage development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    growth plate cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    limb development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    limb development ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    musculoskeletal movement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hemostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of chondrocyte proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of chondrocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to unfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tendon development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vascular smooth muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vascular smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space HDA PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cartilage oligomeric matrix protein
    Names
    thrombospondin-5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016685.2NP_057894.2  cartilage oligomeric matrix protein precursor

      See identical proteins and their annotated locations for NP_057894.2

      Status: VALIDATED

      Source sequence(s)
      AC158553, AF033530, BY328097, CJ324165
      Consensus CDS
      CCDS22367.1
      UniProtKB/Swiss-Prot
      Q9R0G6
      Related
      ENSMUSP00000003659.7, ENSMUST00000003659.8
      Conserved Domains (7) summary
      smart00179
      Location:178216
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:125160
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00001
      Location:395416
      TSP3; TSP3 repeat_short [structural motif]
      sd00002
      Location:299334
      TSP3; TSP3 repeat_long [structural motif]
      pfam02412
      Location:300334
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:544741
      TSP_C; Thrombospondin C-terminal region
      cd16077
      Location:2971
      TSP-5cc; Coiled coil region of thrombospondin-5 (TSP-5)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      70373548..70382066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509539.1XP_006509602.1  cartilage oligomeric matrix protein isoform X1

      Conserved Domains (6) summary
      smart00179
      Location:67105
      EGF_CA; Calcium-binding EGF-like domain
      sd00001
      Location:284305
      TSP3; TSP3 repeat_short [structural motif]
      sd00002
      Location:188223
      TSP3; TSP3 repeat_long [structural motif]
      pfam00008
      Location:1849
      EGF; EGF-like domain
      pfam02412
      Location:189223
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:433630
      TSP_C; Thrombospondin C-terminal region
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