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    ARL8A ADP ribosylation factor like GTPase 8A [ Homo sapiens (human) ]

    Gene ID: 127829, updated on 5-Aug-2018

    Summary

    Official Symbol
    ARL8Aprovided by HGNC
    Official Full Name
    ADP ribosylation factor like GTPase 8Aprovided by HGNC
    Primary source
    HGNC:HGNC:25192
    See related
    Ensembl:ENSG00000143862 MIM:616597; Vega:OTTHUMG00000035923
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GIE2; ARL10B
    Expression
    Ubiquitous expression in brain (RPKM 56.4), bone marrow (RPKM 24.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See ARL8A in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (202133404..202144743, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (202102532..202113871, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371684 Neighboring gene cysteine rich protein 1 pseudogene 3 Neighboring gene uncharacterized LOC105371683 Neighboring gene G protein-coupled receptor 37 like 1 Neighboring gene protein tyrosine phosphatase, non-receptor type 7 Neighboring gene protein tyrosine phosphatase, receptor type V, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    Pathways from BioSystems

    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ45195

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    alpha-tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    beta-tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    azurophil granule membrane TAS
    Traceable Author Statement
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    ficolin-1-rich granule membrane TAS
    Traceable Author Statement
    more info
     
    late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lysosomal membrane HDA PubMed 
    lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane HDA PubMed 
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ADP-ribosylation factor-like protein 8A
    Names
    ADP-ribosylation factor-like 10B
    ADP-ribosylation factor-like 8A
    novel small G protein indispensable for equal chromosome segregation 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256129.1NP_001243058.1  ADP-ribosylation factor-like protein 8A isoform 2

      See identical proteins and their annotated locations for NP_001243058.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AK127138, AW090198, BC069053, BG876867, BP325806
      Consensus CDS
      CCDS73004.1
      UniProtKB/Swiss-Prot
      Q96BM9
      UniProtKB/TrEMBL
      A0A087X2J2
      Related
      ENSP00000485023.1, ENST00000614750.1
      Conserved Domains (1) summary
      cd04159
      Location:22128
      Arl10_like; Arf-like 9 (Arl9) and 10 (Arl10) GTPases
    2. NM_138795.3NP_620150.1  ADP-ribosylation factor-like protein 8A isoform 1

      See identical proteins and their annotated locations for NP_620150.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AW090198, BC015408, BC069053, BP325806
      Consensus CDS
      CCDS1421.1
      UniProtKB/Swiss-Prot
      Q96BM9
      UniProtKB/TrEMBL
      A0A024R977
      Related
      ENSP00000272217.2, OTTHUMP00000034102, ENST00000272217.6, OTTHUMT00000087493
      Conserved Domains (1) summary
      cd04159
      Location:22180
      Arl10_like; Arf-like 9 (Arl9) and 10 (Arl10) GTPases

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      202133404..202144743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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