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    Cdkn1b cyclin-dependent kinase inhibitor 1B [ Mus musculus (house mouse) ]

    Gene ID: 12576, updated on 12-Aug-2018

    Summary

    Official Symbol
    Cdkn1bprovided by MGI
    Official Full Name
    cyclin-dependent kinase inhibitor 1Bprovided by MGI
    Primary source
    MGI:MGI:104565
    See related
    Ensembl:ENSMUSG00000003031 Vega:OTTMUSG00000021172
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p27; Kip1; p27Kip1; AA408329; AI843786
    Expression
    Ubiquitous expression in thymus adult (RPKM 30.0), ovary adult (RPKM 20.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cdkn1b in Genome Data Viewer
    Location:
    6 G1; 6 65.77 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (134920401..134925525)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (134870419..134875543)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 19 Neighboring gene predicted gene, 40407 Neighboring gene RIKEN cDNA 2810454H06 gene Neighboring gene lncRNA downstream of Cdkn1b Neighboring gene predicted gene, 36428 Neighboring gene apolipoprotein L domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein serine/threonine kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    autophagic cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagic cell death ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    cell death ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to antibiotic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to lithium ion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to organic cyclic compound IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inner ear development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle arrest IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular component movement IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cyclin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epithelial cell proliferation involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of vascular smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    placenta development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of microtubule polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of microtubule polymerization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    potassium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    potassium ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of exit from mitosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of exit from mitosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of lens fiber cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of lens fiber cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to amino acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to cadmium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to drug IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to estradiol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to glucose IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to peptide hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sensory perception of sound IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Cul4A-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase inhibitor 1B
    Names
    cyclin-dependent kinase inhibitor p27

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009875.4NP_034005.2  cyclin-dependent kinase inhibitor 1B

      See identical proteins and their annotated locations for NP_034005.2

      Status: VALIDATED

      Source sequence(s)
      AC122193, U10440
      Consensus CDS
      CCDS20642.1
      UniProtKB/Swiss-Prot
      P46414
      Related
      ENSMUSP00000003115.6, OTTMUSP00000023377, ENSMUST00000003115.8, OTTMUST00000050154
      Conserved Domains (1) summary
      pfam02234
      Location:3175
      CDI; Cyclin-dependent kinase inhibitor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      134920401..134925525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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