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    Cav2 caveolin 2 [ Mus musculus (house mouse) ]

    Gene ID: 12390, updated on 2-Oct-2018

    Summary

    Official Symbol
    Cav2provided by MGI
    Official Full Name
    caveolin 2provided by MGI
    Primary source
    MGI:MGI:107571
    See related
    Ensembl:ENSMUSG00000000058 Vega:OTTMUSG00000024026
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI447843
    Summary
    This gene belongs to the caveolin family whose members encode the major protein components of caveolae, which are invaginations of plasma membrane. This gene is located adjacent to caveolin-1 and the proteins coexpressed by the two genes localize together in caveolae, where they form hetero-oligomers. The encoded protein may be involved in diverse cellular functions including proliferation, differentiation, endocytosis and trafficking. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 86.2), genital fat pad adult (RPKM 79.9) and 10 other tissues See more
    Orthologs

    Genomic context

    See Cav2 in Genome Data Viewer
    Location:
    6; 6 A2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (17281185..17289130)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (17231341..17239011)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene 4876 Neighboring gene testis derived transcript Neighboring gene predicted gene 4876 Neighboring gene RIKEN cDNA D830026I12 gene Neighboring gene caveolin 1, caveolae protein Neighboring gene predicted gene, 46953

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from BioSystems

    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Integrin-mediated Cell Adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated Cell Adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Splicing factor NOVA regulated synaptic proteins, organism-specific biosystem (from WikiPathways)
      Splicing factor NOVA regulated synaptic proteins, organism-specific biosystemSynaptic Communication influenced by NOVA-splicing regulation

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    D1 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    D1 dopamine receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    SNARE binding ISO
    Inferred from Sequence Orthology
    more info
     
    mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding, bridging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex scaffold activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-containing complex scaffold activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    caveola assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    caveola assembly ISO
    Inferred from Sequence Orthology
    more info
     
    caveola assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    endocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of endothelial cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation by host of viral process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation by host of viral release from host cell ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dopamine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of endothelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex oligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor-mediated endocytosis of virus by host cell ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vesicle docking ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle docking ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    vesicle organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    acrosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with caveola IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    caveola ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    caveola ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    colocalizes_with focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277756.1NP_001264685.1  caveolin-2 isoform 2

      See identical proteins and their annotated locations for NP_001264685.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) transcribes past a splice site that is used in variant 1. This results in a novel 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter at the C-terminus, compared to isoform 1.
      Source sequence(s)
      AA475015, AC023173
      Consensus CDS
      CCDS71727.1
      UniProtKB/TrEMBL
      Q924U4
      Related
      ENSMUSP00000111119.1, OTTMUSP00000028504, ENSMUST00000115459.1, OTTMUST00000058749
      Conserved Domains (1) summary
      pfam01146
      Location:39113
      Caveolin; Caveolin
    2. NM_016900.4NP_058596.1  caveolin-2 isoform 1

      See identical proteins and their annotated locations for NP_058596.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC023173, AK009913, AK151397, AK158419, CJ157462
      Consensus CDS
      CCDS19923.1
      UniProtKB/Swiss-Prot
      Q9WVC3
      Related
      ENSMUSP00000000058.6, OTTMUSP00000028503, ENSMUST00000000058.6, OTTMUST00000058748
      Conserved Domains (1) summary
      pfam01146
      Location:39160
      Caveolin; Caveolin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      17281185..17289130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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