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    CCR7 C-C motif chemokine receptor 7 [ Homo sapiens (human) ]

    Gene ID: 1236, updated on 18-Sep-2018

    Summary

    Official Symbol
    CCR7provided by HGNC
    Official Full Name
    C-C motif chemokine receptor 7provided by HGNC
    Primary source
    HGNC:HGNC:1608
    See related
    Ensembl:ENSG00000126353 MIM:600242; Vega:OTTHUMG00000133375
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7
    Summary
    The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
    Expression
    Biased expression in lymph node (RPKM 35.2), appendix (RPKM 32.5) and 6 other tissues See more
    Orthologs

    Genomic context

    See CCR7 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (40553769..40565484, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38710021..38721736, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101059954 Neighboring gene uncharacterized LOC107985090 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 Neighboring gene keratin 222

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CCR7 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the level of CXCR4/CCR7 hetero-oligomerization in CD4+ T cells PubMed
    env HIV-1 gp120 interacts with CD4 and CXCR4 to enhance CCR7-dependent human CD4+ T cell migration PubMed
    env Stimulated HIV-1 infected CD4+ cells induce plasmacytoid dendritic cell (PDC) activation and maturation in a manner that is inhibited by antibodies to HIV-1 gp120; markers for PDC migration (CCR7) are enhanced during this process PubMed
    env Inhibition of CpG-B-induced maturation of plasmacytoid dendritic cells by HIV-1 gp120 results in downregulation of CD40, CD83, CCR7, and HLA-DR expression PubMed
    env HIV-1 gp120 interactions with CXCR4 and CCR5 lead to the cross-desensitization of CCR6 and CCR7; this gp120-induced inhibition is strictly dependent on CXCR4 or CCR5 and lipid rafts but not on CD4 or V(H)3-expressing BCR PubMed
    Nef nef HIV-1 Nef induces variable levels of CCR7 downregulation in different cell types PubMed
    nef HIV-1 Nef-pulsed mDCs downregulate HLA-DR expression and upregulate CD25 and CCR7 expression in NK cells PubMed
    Vif vif HIV-1 Vif upregulates the expression of chemokine (C-C motif) receptor 7 (CCR7) in Vif-expression T cells PubMed
    Vpu vpu HIV-1 (NL4-3) Vpu downregulates CCR7 expression on cells (primary CD4+ T cells) PubMed
    vpu HIV-1 (NL4-3) Vpu downregulates CCR7 via a cullin-RING E3 ubiquitin ligase complex-independent mechanism PubMed
    vpu HIV-1 Vpu is necessary and sufficient for cell-surface CCR7 downregulation but not degradation of CCR7, and the trans-membrane domain of Vpu is required for downregulation of CCR7 in CD4+ T cells PubMed
    vpu Vpu-mediated downregulation of CCR7 upon viral infection results in an impaired ability of infected primary CD4+ T cells to respond to CCL19 PubMed
    vpu HIV-1 Vpu specifically co-localizes with CCR7 within the trans-Golgi network cellular compartment PubMed
    matrix gag Treatment of plasmacytoid dendritic cells (pDCs) with HIV-1 MA upregulates the expression of CCR7. Coculture with MA and CCL19 induces a dose-dependent migration of pDCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
      Chemokine receptors bind chemokines, organism-specific biosystemChemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of i...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
      Peptide GPCRs, organism-specific biosystem
      Peptide GPCRs
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    C-C chemokine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    C-C motif chemokine 19 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    C-C motif chemokine 19 receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    C-C motif chemokine 21 receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    chemokine (C-C motif) ligand 19 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chemokine (C-C motif) ligand 19 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chemokine (C-C motif) ligand 21 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chemokine (C-C motif) ligand 21 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    activation of GTPase activity IC
    Inferred by Curator
    more info
    PubMed 
    calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to cytokine stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemokine (C-C motif) ligand 19 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    chemokine (C-C motif) ligand 21 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dendritic cell chemotaxis IC
    Inferred by Curator
    more info
    PubMed 
    establishment of T cell polarity IC
    Inferred by Curator
    more info
    PubMed 
    homeostasis of number of cells IEA
    Inferred from Electronic Annotation
    more info
     
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    interleukin-12 secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lymphocyte migration into lymph node TAS
    Traceable Author Statement
    more info
    PubMed 
    mature conventional dendritic cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    myeloid dendritic cell chemotaxis IC
    Inferred by Curator
    more info
    PubMed 
    myeloid dendritic cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of dendritic cell apoptotic process IC
    Inferred by Curator
    more info
    PubMed 
    negative thymic T cell selection IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of JNK cascade IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of T cell costimulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of actin filament polymerization IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of cell adhesion IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of cell motility IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of cell-matrix adhesion IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of dendritic cell antigen processing and presentation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of dendritic cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of filopodium assembly IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of humoral immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of hypersensitivity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of immunological synapse formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-12 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of neutrophil chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase activity IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of protein kinase B signaling IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of protein kinase activity IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of pseudopodium assembly IC
    Inferred by Curator
    more info
    PubMed 
    regulation of dendritic cell dendrite assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of interferon-gamma production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of interleukin-1 beta secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    release of sequestered calcium ion into cytosol IC
    Inferred by Curator
    more info
    PubMed 
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    response to nitric oxide IC
    Inferred by Curator
    more info
    PubMed 
    response to prostaglandin E IC
    Inferred by Curator
    more info
    PubMed 
    ruffle organization IC
    Inferred by Curator
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    C-C chemokine receptor type 7
    Names
    Bukitt's lymphoma receptor 2
    CC chemokine receptor 7
    EBV-induced G protein-coupled receptor 1
    Epstein-Barr virus induced gene 1
    Epstein-Barr virus-induced G-protein coupled receptor 1
    MIP-3 beta receptor
    chemokine (C-C motif) receptor 7
    lymphocyte-specific G protein-coupled peptide receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301714.1NP_001288643.1  C-C chemokine receptor type 7 isoform b

      See identical proteins and their annotated locations for NP_001288643.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      BC035343, BI910219, DA814913
      UniProtKB/Swiss-Prot
      P32248
      Conserved Domains (1) summary
      pfam00001
      Location:12263
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. NM_001301716.1NP_001288645.1  C-C chemokine receptor type 7 isoform c precursor

      See identical proteins and their annotated locations for NP_001288645.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
      Source sequence(s)
      AK310277, BC035343
      Consensus CDS
      CCDS77026.1
      UniProtKB/Swiss-Prot
      P32248
      UniProtKB/TrEMBL
      J3KSS9
      Related
      ENSP00000462631.1, OTTHUMP00000262360, ENST00000579344.1, OTTHUMT00000447526
      Conserved Domains (1) summary
      cd15175
      Location:53331
      7tmA_CCR7; CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001301717.1NP_001288646.1  C-C chemokine receptor type 7 isoform c precursor

      See identical proteins and their annotated locations for NP_001288646.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
      Source sequence(s)
      AK310277, BC035343, HY017993
      Consensus CDS
      CCDS77026.1
      UniProtKB/Swiss-Prot
      P32248
      UniProtKB/TrEMBL
      J3KSS9
      Conserved Domains (1) summary
      cd15175
      Location:53331
      7tmA_CCR7; CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. NM_001301718.1NP_001288647.1  C-C chemokine receptor type 7 isoform c precursor

      See identical proteins and their annotated locations for NP_001288647.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
      Source sequence(s)
      BC035343, HY021417
      Consensus CDS
      CCDS77026.1
      UniProtKB/Swiss-Prot
      P32248
      UniProtKB/TrEMBL
      J3KSS9
      Conserved Domains (1) summary
      cd15175
      Location:53331
      7tmA_CCR7; CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors
    5. NM_001838.3NP_001829.1  C-C chemokine receptor type 7 isoform a precursor

      See identical proteins and their annotated locations for NP_001829.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC035343, DA814913, L31581
      Consensus CDS
      CCDS11369.1
      UniProtKB/Swiss-Prot
      P32248
      UniProtKB/TrEMBL
      A0N0Q0
      Related
      ENSP00000246657.2, OTTHUMP00000164532, ENST00000246657.2, OTTHUMT00000257222
      Conserved Domains (1) summary
      cd15175
      Location:59337
      7tmA_CCR7; CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      40553769..40565484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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