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    Btg1 BTG anti-proliferation factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 12226, updated on 18-Sep-2024

    Summary

    Official Symbol
    Btg1provided by MGI
    Official Full Name
    BTG anti-proliferation factor 1provided by MGI
    Primary source
    MGI:MGI:88215
    See related
    Ensembl:ENSMUSG00000036478 AllianceGenome:MGI:88215
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable enzyme binding activity. Acts upstream of or within negative regulation of cell population proliferation and protein methylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; central nervous system; limb; maxillary process; and sensory organ. Orthologous to human BTG1 (BTG anti-proliferation factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen adult (RPKM 18.3), bladder adult (RPKM 12.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Btg1 in Genome Data Viewer
    Location:
    10 C3; 10 49.89 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (96452863..96458675)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (96617001..96622813)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_27673 Neighboring gene predicted gene, 33843 Neighboring gene STARR-positive B cell enhancer mm9_chr10:96055025-96055325 Neighboring gene STARR-positive B cell enhancer ABC_E5174 Neighboring gene STARR-positive B cell enhancer ABC_E11757 Neighboring gene STARR-positive B cell enhancer ABC_E302 Neighboring gene STARR-seq mESC enhancer starr_27675 Neighboring gene STARR-seq mESC enhancer starr_27677 Neighboring gene STARR-seq mESC enhancer starr_27678 Neighboring gene STARR-seq mESC enhancer starr_27679 Neighboring gene STARR-seq mESC enhancer starr_27680 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:96160609-96160762 Neighboring gene VISTA enhancer mm313 Neighboring gene STARR-seq mESC enhancer starr_27683 Neighboring gene STARR-seq mESC enhancer starr_27684 Neighboring gene predicted gene, 33897 Neighboring gene STARR-seq mESC enhancer starr_27685 Neighboring gene STARR-seq mESC enhancer starr_27686 Neighboring gene transaldolase 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of catalytic activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of fibroblast apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein BTG1
    Names
    B cell translocation gene 1, anti-proliferative
    B-cell translocation gene 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007569.2NP_031595.1  protein BTG1

      See identical proteins and their annotated locations for NP_031595.1

      Status: VALIDATED

      Source sequence(s)
      AC155936
      Consensus CDS
      CCDS24140.1
      UniProtKB/Swiss-Prot
      P62325
      UniProtKB/TrEMBL
      Q3TRH7, Q3UEG0
      Related
      ENSMUSP00000038863.8, ENSMUST00000038377.9
      Conserved Domains (1) summary
      smart00099
      Location:11118
      btg1; tob/btg1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      96452863..96458675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)