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    FGD4 FYVE, RhoGEF and PH domain containing 4 [ Homo sapiens (human) ]

    Gene ID: 121512, updated on 18-Sep-2018

    Summary

    Official Symbol
    FGD4provided by HGNC
    Official Full Name
    FYVE, RhoGEF and PH domain containing 4provided by HGNC
    Primary source
    HGNC:HGNC:19125
    See related
    Ensembl:ENSG00000139132 MIM:611104; Vega:OTTHUMG00000137374
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CMT4H; FRABP; ZFYVE6
    Summary
    This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
    Expression
    Ubiquitous expression in ovary (RPKM 8.0), stomach (RPKM 6.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See FGD4 in Genome Data Viewer
    Location:
    12p11.21
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (32399523..32646050)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (32552518..32798984)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984473 Neighboring gene BICD cargo adaptor 1 Neighboring gene WW domain binding protein 2 pseudogene Neighboring gene RNA, U6 small nuclear 494, pseudogene Neighboring gene nucleosome assembly protein 1 like 1 pseudogene Neighboring gene dynamin 1 like Neighboring gene tyrosyl-tRNA synthetase 2 Neighboring gene plakophilin 2 Neighboring gene ribosomal protein L35a pseudogene 27

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
      Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
    • G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
      NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
      p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ34370, FLJ42663, MGC57222, DKFZp313E1818, DKFZp434K1572

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Rho guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ruffle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    FYVE, RhoGEF and PH domain-containing protein 4
    Names
    FGD1 family, member 4
    FGD1-related F-actin-binding protein
    actin-filament binding protein frabin
    zinc finger FYVE domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008626.2 RefSeqGene

      Range
      91444..251522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_240

    mRNA and Protein(s)

    1. NM_001304480.1NP_001291409.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC084824, AC090440, AK057294, AK303334, AL832064, DA657803
      Consensus CDS
      CCDS76545.1
      UniProtKB/Swiss-Prot
      Q96M96
      UniProtKB/TrEMBL
      B7Z8F9, E9PJX4
      Related
      ENSP00000433666.1, OTTHUMP00000233838, ENST00000525053.5, OTTHUMT00000390888
      Conserved Domains (5) summary
      cd13236
      Location:749851
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:535628
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:666730
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
      pfam00169
      Location:535632
      PH; PH domain
      pfam00621
      Location:322503
      RhoGEF; RhoGEF domain
    2. NM_001304481.1NP_001291410.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001291410.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC084824, AC090440, AK297025, AL832064
      Consensus CDS
      CCDS76544.1
      UniProtKB/TrEMBL
      B7Z493
      Related
      ENSP00000431323.1, OTTHUMP00000233837, ENST00000531134.5, OTTHUMT00000390887
      Conserved Domains (5) summary
      cd13236
      Location:722824
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:508601
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:639703
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
      pfam00169
      Location:508605
      PH; PH domain
      pfam00621
      Location:295476
      RhoGEF; RhoGEF domain
    3. NM_001304483.1NP_001291412.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 4

      See identical proteins and their annotated locations for NP_001291412.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has alternate 5' and 3' terminal sequences and an additional internal exon, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL832064, BC045552, BC096746, BI756188
      UniProtKB/TrEMBL
      Q49A55
      Conserved Domains (5) summary
      cd15791
      Location:175268
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:306370
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
      pfam00169
      Location:175272
      PH; PH domain
      pfam00621
      Location:2143
      RhoGEF; RhoGEF domain
      cl17171
      Location:389440
      PH-like; Pleckstrin homology-like domain
    4. NM_001304484.1NP_001291413.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) is the longest transcript, but encodes the shortest isoform. It has multiple differences in the 5' region, compared to variant 1. The resulting isoform (5) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC084824, AC090440, AK303334, AL832064, BC039708, BC096746
      UniProtKB/TrEMBL
      B7Z8F9
      Conserved Domains (5) summary
      cd13236
      Location:293395
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:79172
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:210274
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
      pfam00169
      Location:79176
      PH; PH domain
      cl02571
      Location:147
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    5. NM_001330373.1NP_001317302.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (6) has a shorter N-terminus, compared to to isoform 1. Variants 6 and 7 encode the same isoform (6)
      Source sequence(s)
      AC084824, AC090440, AK057294, AL832064, BC039708, BC096746, BI752085
      Consensus CDS
      CCDS81679.1
      UniProtKB/Swiss-Prot
      Q96M96
      UniProtKB/TrEMBL
      F8W1R0
      Related
      ENSP00000446695.1, ENST00000546442.5
      Conserved Domains (4) summary
      cd00160
      Location:114298
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:544646
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:330423
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:461525
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    6. NM_001330374.1NP_001317303.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The resulting isoform (6) has a shorter N-terminus, compared to to isoform 1. Variants 6 and 7 encode the same isoform (6).
      Source sequence(s)
      AC084824, AC090440, AK057294, AK297025, AL832064, BC039708, BC096746, BI752085
      Consensus CDS
      CCDS81679.1
      UniProtKB/Swiss-Prot
      Q96M96
      UniProtKB/TrEMBL
      B7Z493, F8W1R0
      Conserved Domains (4) summary
      cd00160
      Location:114298
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:544646
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:330423
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:461525
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    7. NM_139241.3NP_640334.2  FYVE, RhoGEF and PH domain-containing protein 4 isoform 3

      See identical proteins and their annotated locations for NP_640334.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate 5' terminal exon, which results in a different 5' UTR and translation initiation at a downstream AUG start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC084824, AC090440, AK057294, AL832064, BC039708, BC096746
      Consensus CDS
      CCDS8727.1
      UniProtKB/Swiss-Prot
      Q96M96
      Related
      ENSP00000394487.2, OTTHUMP00000174413, ENST00000427716.6, OTTHUMT00000268017
      Conserved Domains (5) summary
      cd13236
      Location:637739
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:423516
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:554618
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
      pfam00169
      Location:423520
      PH; PH domain
      pfam00621
      Location:210391
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      32399523..32646050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005253304.4XP_005253361.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X1

      Related
      ENSP00000449273.1, OTTHUMP00000241155, ENST00000534526.6, OTTHUMT00000404118
      Conserved Domains (5) summary
      cd13236
      Location:801903
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:587680
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:718782
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
      pfam00169
      Location:587684
      PH; PH domain
      pfam00621
      Location:374555
      RhoGEF; RhoGEF domain
    2. XM_017018803.1XP_016874292.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X3

    3. XM_005253309.1XP_005253366.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X5

      See identical proteins and their annotated locations for XP_005253366.1

      UniProtKB/TrEMBL
      F8W1R0
      Conserved Domains (4) summary
      cd00160
      Location:114298
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:544646
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:330423
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:461525
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    4. XM_024448840.1XP_024304608.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X10

      Conserved Domains (4) summary
      cd13236
      Location:340442
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:126219
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:257321
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
      pfam00621
      Location:194
      RhoGEF; RhoGEF domain
    5. XM_024448837.1XP_024304605.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X5

      Conserved Domains (4) summary
      cd00160
      Location:114298
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:544646
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:330423
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:461525
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    6. XM_024448838.1XP_024304606.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X5

      Conserved Domains (4) summary
      cd00160
      Location:114298
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:544646
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:330423
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:461525
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    7. XM_024448839.1XP_024304607.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X5

      Conserved Domains (4) summary
      cd00160
      Location:114298
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:544646
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:330423
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:461525
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    8. XM_011520556.1XP_011518858.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X4

      See identical proteins and their annotated locations for XP_011518858.1

      UniProtKB/Swiss-Prot
      Q96M96
      Conserved Domains (5) summary
      cd13236
      Location:637739
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:423516
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:554618
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
      pfam00169
      Location:423520
      PH; PH domain
      pfam00621
      Location:210391
      RhoGEF; RhoGEF domain
    9. XM_017018805.1XP_016874294.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X6

      Conserved Domains (5) summary
      cd13236
      Location:453555
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:239332
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:370434
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
      pfam00169
      Location:239336
      PH; PH domain
      pfam00621
      Location:26207
      RhoGEF; RhoGEF domain
    10. XM_011520554.1XP_011518856.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X2

      Conserved Domains (5) summary
      cd13236
      Location:735837
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:521614
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:652716
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
      pfam00169
      Location:521618
      PH; PH domain
      pfam00621
      Location:308489
      RhoGEF; RhoGEF domain
    11. XM_005253308.5XP_005253365.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X5

      See identical proteins and their annotated locations for XP_005253365.1

      UniProtKB/TrEMBL
      F8W1R0
      Conserved Domains (4) summary
      cd00160
      Location:114298
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13236
      Location:544646
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:330423
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:461525
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    12. XM_011520557.1XP_011518859.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X6

      Conserved Domains (5) summary
      cd13236
      Location:453555
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:239332
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:370434
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
      pfam00169
      Location:239336
      PH; PH domain
      pfam00621
      Location:26207
      RhoGEF; RhoGEF domain
    13. XM_011520555.1XP_011518857.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X4

      See identical proteins and their annotated locations for XP_011518857.1

      UniProtKB/Swiss-Prot
      Q96M96
      Conserved Domains (5) summary
      cd13236
      Location:637739
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:423516
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:554618
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
      pfam00169
      Location:423520
      PH; PH domain
      pfam00621
      Location:210391
      RhoGEF; RhoGEF domain
    14. XM_005253310.4XP_005253367.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X8

      Conserved Domains (5) summary
      cd13236
      Location:389491
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:175268
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:306370
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
      pfam00169
      Location:175272
      PH; PH domain
      pfam00621
      Location:2143
      RhoGEF; RhoGEF domain
    15. XM_011520558.2XP_011518860.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X7

      Conserved Domains (5) summary
      cd13236
      Location:438540
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:224317
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:355419
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
      pfam00169
      Location:224321
      PH; PH domain
      pfam00621
      Location:11192
      RhoGEF; RhoGEF domain
    16. XM_011520559.3XP_011518861.1  FYVE, RhoGEF and PH domain-containing protein 4 isoform X9

      Conserved Domains (5) summary
      cd13236
      Location:382484
      PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
      cd15791
      Location:168261
      PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
      cd15741
      Location:299363
      FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
      pfam00169
      Location:168265
      PH; PH domain
      pfam00621
      Location:21136
      RhoGEF; RhoGEF domain

    RNA

    1. XR_001748576.1 RNA Sequence

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