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    Cspg4 chondroitin sulfate proteoglycan 4 [ Mus musculus (house mouse) ]

    Gene ID: 121021, updated on 21-Oct-2021

    Summary

    Official Symbol
    Cspg4provided by MGI
    Official Full Name
    chondroitin sulfate proteoglycan 4provided by MGI
    Primary source
    MGI:MGI:2153093
    See related
    Ensembl:ENSMUSG00000032911
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AN2; NG2; Cspg4a; 4732461B14Rik
    Expression
    Broad expression in limb E14.5 (RPKM 17.6), mammary gland adult (RPKM 12.2) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Cspg4 in Genome Data Viewer
    Location:
    9; 9 B
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (56772388..56807154)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56865104..56899870)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (56712911..56747677)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and Ig domain containing 1 Neighboring gene predicted gene, 53525 Neighboring gene predicted gene, 31586 Neighboring gene outer dense fiber of sperm tails 3-like 1 Neighboring gene sorting nexin 33 Neighboring gene predicted gene, 19936

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (7)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables coreceptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ruffle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within substrate-dependent cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within tissue remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within transmembrane receptor protein tyrosine kinase signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    chondroitin sulfate proteoglycan 4
    Names
    AN2 proteoglycan
    AN2/NG2 proteoglycan
    chondroitin sulfate proteoglycan NG2
    nerve/glial antigen 2
    proteoglycan AN2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139001.2NP_620570.2  chondroitin sulfate proteoglycan 4 precursor

      See identical proteins and their annotated locations for NP_620570.2

      Status: VALIDATED

      Source sequence(s)
      AC126257, AF352400, AK052394, AK140986, AK220559
      Consensus CDS
      CCDS23211.1
      UniProtKB/Swiss-Prot
      Q8VHY0
      UniProtKB/TrEMBL
      Q3URZ9
      Related
      ENSMUSP00000038909.6, ENSMUST00000035661.7
      Conserved Domains (3) summary
      cd00110
      Location:204362
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam16184
      Location:14251568
      Cadherin_3; Cadherin-like
      cl22861
      Location:55182
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      56772388..56807154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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