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    Cspg4 chondroitin sulfate proteoglycan 4 [ Mus musculus (house mouse) ]

    Gene ID: 121021, updated on 21-May-2024

    Summary

    Official Symbol
    Cspg4provided by MGI
    Official Full Name
    chondroitin sulfate proteoglycan 4provided by MGI
    Primary source
    MGI:MGI:2153093
    See related
    Ensembl:ENSMUSG00000032911 AllianceGenome:MGI:2153093
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AN2; NG2; Cspg4a; 4732461B14Rik
    Summary
    Enables coreceptor activity. Acts upstream of or within several processes, including platelet-derived growth factor receptor signaling pathway; positive regulation of MAPK cascade; and ruffle assembly. Located in plasma membrane and ruffle. Is expressed in several structures, including brain; jaw; respiratory system; retina; and skeleton. Human ortholog(s) of this gene implicated in relapsing-remitting multiple sclerosis. Orthologous to human CSPG4 (chondroitin sulfate proteoglycan 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 17.6), mammary gland adult (RPKM 12.2) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Cspg4 in Genome Data Viewer
    Location:
    9 B; 9 30.32 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (56772388..56807154)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56865104..56899870)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and Ig domain containing 1 Neighboring gene predicted gene, 53525 Neighboring gene predicted gene, 31586 Neighboring gene ciliary microtubule associated protein 1C Neighboring gene STARR-positive B cell enhancer ABC_E10548 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56776219-56776328 Neighboring gene sorting nexin 33 Neighboring gene predicted gene, 19936

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables coreceptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    chondroitin sulfate proteoglycan 4
    Names
    AN2 proteoglycan
    AN2/NG2 proteoglycan
    chondroitin sulfate proteoglycan NG2
    nerve/glial antigen 2
    proteoglycan AN2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139001.2NP_620570.2  chondroitin sulfate proteoglycan 4 precursor

      See identical proteins and their annotated locations for NP_620570.2

      Status: VALIDATED

      Source sequence(s)
      AC126257, AF352400, AK052394, AK140986, AK220559
      Consensus CDS
      CCDS23211.1
      UniProtKB/Swiss-Prot
      G5E892, Q5DTG1, Q8BPI8, Q8CE79, Q8VHY0
      Related
      ENSMUSP00000038909.6, ENSMUST00000035661.7
      Conserved Domains (3) summary
      cd00110
      Location:204362
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam16184
      Location:14251568
      Cadherin_3; Cadherin-like
      cl22861
      Location:55182
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      56772388..56807154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)