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    ADCYAP1R1 ADCYAP receptor type I [ Homo sapiens (human) ]

    Gene ID: 117, updated on 17-Jun-2018
    Official Symbol
    ADCYAP1R1provided by HGNC
    Official Full Name
    ADCYAP receptor type Iprovided by HGNC
    Primary source
    HGNC:HGNC:242
    See related
    Ensembl:ENSG00000078549 MIM:102981; Vega:OTTHUMG00000023884
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAC1; PAC1R; PACAPR; PACAPRI
    Summary
    This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]
    Expression
    Biased expression in brain (RPKM 39.8), adrenal (RPKM 5.5) and 1 other tissue See more
    Orthologs
    See ADCYAP1R1 in Genome Data Viewer
    Location:
    7p14.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (31052341..31111479)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (31092076..31151093)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375222 Neighboring gene growth hormone releasing hormone receptor Neighboring gene uncharacterized LOC105375221 Neighboring gene small integral membrane protein 14 pseudogene Neighboring gene uncharacterized LOC107986781 Neighboring gene uncharacterized LOC107986782

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
    NHGRI GWA Catalog
    Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples.
    NHGRI GWA Catalog
    • Activation of TRKA receptors, organism-specific biosystem (from REACTOME)
      Activation of TRKA receptors, organism-specific biosystemTrk receptors can either be activated by neurotrophins or by two G-protein-coupled receptors (GPCRs) although the biological relevance of GPCRs remains to be shown.
    • Circadian entrainment, organism-specific biosystem (from KEGG)
      Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
    • Circadian entrainment, conserved biosystem (from KEGG)
      Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
    • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
      Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
    • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class B Secretin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class B Secretin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • Glucagon-type ligand receptors, organism-specific biosystem (from REACTOME)
      Glucagon-type ligand receptors, organism-specific biosystemThe glucagon hormone family regulates the activity of GPCRs from the secretin receptor subfamily in Class II/B (Mayo KE et al, 2003).
    • Insulin secretion, organism-specific biosystem (from KEGG)
      Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • NGF-independant TRKA activation, organism-specific biosystem (from REACTOME)
      NGF-independant TRKA activation, organism-specific biosystemTRK receptors can also be activated by at least two G-protein-coupled receptors (GPCR), the adenosine A2a receptor and the PACAP type I receptor, without involvement of neurotrophins. Activity of bo...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Renin secretion, organism-specific biosystem (from KEGG)
      Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Renin secretion, conserved biosystem (from KEGG)
      Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
      Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ADP-ribosylation factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    G-protein coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adenylate cyclase binding IEA
    Inferred from Electronic Annotation
    more info
     
    neuropeptide binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    vasoactive intestinal polypeptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    activation of phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
     
    cAMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    development of primary female sexual characteristics IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organismal response to stress IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell death IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cAMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of calcium ion transport into cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of inositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    caveola IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    pituitary adenylate cyclase-activating polypeptide type I receptor
    Names
    PACAP receptor 1
    PACAP type I receptor
    PACAP-R1
    adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
    pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop
    pituitary adenylate cyclase-activating polypeptide type 1 receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029869.1 RefSeqGene

      Range
      5001..64018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001118.4NP_001109.2  pituitary adenylate cyclase-activating polypeptide type I receptor isoform 3 precursor

      See identical proteins and their annotated locations for NP_001109.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC006466, AK290046, CA432770, DA809763
      Consensus CDS
      CCDS5433.1
      UniProtKB/Swiss-Prot
      P41586
      UniProtKB/TrEMBL
      A0A090N8F8
      Related
      ENSP00000306620.4, OTTHUMP00000123435, ENST00000304166.8, OTTHUMT00000215041
      Conserved Domains (2) summary
      pfam02793
      Location:52137
      HRM; Hormone receptor domain
      cd15987
      Location:150417
      7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    2. NM_001199635.1NP_001186564.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_001186564.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC006466, BC136267, CA432770, DA809763
      Consensus CDS
      CCDS56480.1
      UniProtKB/Swiss-Prot
      P41586
      Related
      ENSP00000483721.1, ENST00000614107.4
      Conserved Domains (2) summary
      pfam02793
      Location:52137
      HRM; Hormone receptor domain
      cd15987
      Location:150445
      7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
    3. NM_001199636.1NP_001186565.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001186565.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal aa, compared to isoform 1.
      Source sequence(s)
      AC006466, BC143679, CA432770, DA809763
      UniProtKB/Swiss-Prot
      P41586
      Conserved Domains (2) summary
      pfam00002
      Location:150423
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:52137
      HRM; Hormone receptor domain
    4. NM_001199637.1NP_001186566.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform 4 precursor

      See identical proteins and their annotated locations for NP_001186566.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two consecutive exons in the upstream region and one exon in the downstream region in the CDS, as compared to variant 1. The resulting isoform (3) lacks two internal segments, as compared to isoform 1.
      Source sequence(s)
      AC006466, AK226138, CA432770, DA809763
      Consensus CDS
      CCDS56481.1
      UniProtKB/Swiss-Prot
      P41586
      Related
      ENSP00000387335.1, OTTHUMP00000202503, ENST00000409363.5, OTTHUMT00000328078
      Conserved Domains (2) summary
      pfam02793
      Location:52116
      HRM; Hormone receptor domain
      cd15987
      Location:129396
      7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

      Range
      31052341..31111479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011738.2XP_016867227.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X4

    2. XM_005249618.5XP_005249675.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X5

      UniProtKB/Swiss-Prot
      P41586
      Conserved Domains (2) summary
      pfam00002
      Location:93339
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:4680
      HRM; Hormone receptor domain
    3. XM_006715645.3XP_006715708.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1

      See identical proteins and their annotated locations for XP_006715708.1

      Related
      ENSP00000386395.1, ENST00000409489.5
      Conserved Domains (2) summary
      pfam00002
      Location:150424
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:52137
      HRM; Hormone receptor domain
    4. XM_017011736.2XP_016867225.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X2

      Conserved Domains (2) summary
      pfam00002
      Location:143417
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:52130
      HRM; Hormone receptor domain
    5. XM_017011737.2XP_016867226.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X3

      UniProtKB/Swiss-Prot
      P41586
      Conserved Domains (2) summary
      pfam00002
      Location:129403
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02793
      Location:52116
      HRM; Hormone receptor domain
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