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    Akt2 thymoma viral proto-oncogene 2 [ Mus musculus (house mouse) ]

    Gene ID: 11652, updated on 25-Oct-2020

    Summary

    Official Symbol
    Akt2provided by MGI
    Official Full Name
    thymoma viral proto-oncogene 2provided by MGI
    Primary source
    MGI:MGI:104874
    See related
    Ensembl:ENSMUSG00000004056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PK; PKB; PKBbe; PKBbeta; AW554154; 2410016A19Rik
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 40.3), mammary gland adult (RPKM 35.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Akt2 in Genome Data Viewer
    Location:
    7 A3; 7 15.94 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27290977..27340251)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27591552..27640826)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (28376579..28424472)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310022A10 gene Neighboring gene predicted gene, 45975 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene, 38973 Neighboring gene mitogen-activated protein kinase kinase kinase 10 Neighboring gene tetratricopeptide repeat domain 9B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC14031

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    activation of GTPase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to high light intensity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular protein transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of plasma membrane long-chain fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peripheral nervous system myelin maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose import IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    response to insulin ISO
    Inferred from Sequence Orthology
    more info
     
    retinal rod cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell cortex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    insulin-responsive compartment ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RAC-beta serine/threonine-protein kinase
    Names
    PKB beta
    RAC-PK-beta
    protein kinase Akt-2
    protein kinase B, beta
    NP_001103678.1
    NP_001318037.1
    NP_001318038.1
    NP_031460.1
    XP_006539544.1
    XP_006539545.1
    XP_006539546.1
    XP_030097857.1
    XP_030097858.1
    XP_030097859.1
    XP_030097860.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110208.2NP_001103678.1  RAC-beta serine/threonine-protein kinase

      See identical proteins and their annotated locations for NP_001103678.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK028871, AK158792, BM899551, CJ159088
      Consensus CDS
      CCDS21027.1
      UniProtKB/Swiss-Prot
      Q60823
      UniProtKB/TrEMBL
      Q3TY95, Q8CE74
      Related
      ENSMUSP00000103981.2, ENSMUST00000108344.8
      Conserved Domains (2) summary
      cd05595
      Location:156478
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    2. NM_001331108.1NP_001318037.1  RAC-beta serine/threonine-protein kinase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC074312, BM899551
      Consensus CDS
      CCDS21027.1
      UniProtKB/Swiss-Prot
      Q60823
      UniProtKB/TrEMBL
      Q3TY95
      Conserved Domains (2) summary
      cd05595
      Location:156478
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    3. NM_001331109.1NP_001318038.1  RAC-beta serine/threonine-protein kinase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK028871, BC040377, BM899551
      Consensus CDS
      CCDS21027.1
      UniProtKB/Swiss-Prot
      Q60823
      UniProtKB/TrEMBL
      Q3TY95, Q8CE74
      Conserved Domains (2) summary
      cd05595
      Location:156478
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    4. NM_007434.4NP_031460.1  RAC-beta serine/threonine-protein kinase

      See identical proteins and their annotated locations for NP_031460.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK028871, AK158792, BM899551, CJ152468
      Consensus CDS
      CCDS21027.1
      UniProtKB/Swiss-Prot
      Q60823
      UniProtKB/TrEMBL
      Q3TY95, Q8CE74
      Related
      ENSMUSP00000052103.5, ENSMUST00000051356.11
      Conserved Domains (2) summary
      cd05595
      Location:156478
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      27290977..27340251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539482.3XP_006539545.1  RAC-beta serine/threonine-protein kinase isoform X2

      See identical proteins and their annotated locations for XP_006539545.1

    2. XM_030241998.1XP_030097858.1  RAC-beta serine/threonine-protein kinase isoform X1

      Conserved Domains (2) summary
      cd05595
      Location:156478
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    3. XM_030241997.2XP_030097857.1  RAC-beta serine/threonine-protein kinase isoform X1

      Conserved Domains (2) summary
      cd05595
      Location:156478
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    4. XM_006539483.2XP_006539546.1  RAC-beta serine/threonine-protein kinase isoform X2

      See identical proteins and their annotated locations for XP_006539546.1

      Conserved Domains (3) summary
      cd05595
      Location:113435
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      smart00220
      Location:109366
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl17171
      Location:468
      PH-like; Pleckstrin homology-like domain
    5. XM_030241999.1XP_030097859.1  RAC-beta serine/threonine-protein kinase isoform X1

      Related
      ENSMUSP00000103980.1, ENSMUST00000108343.7
      Conserved Domains (2) summary
      cd05595
      Location:156478
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    6. XM_006539481.5XP_006539544.1  RAC-beta serine/threonine-protein kinase isoform X1

      See identical proteins and their annotated locations for XP_006539544.1

      UniProtKB/Swiss-Prot
      Q60823
      UniProtKB/TrEMBL
      Q3TY95
      Conserved Domains (2) summary
      cd05595
      Location:156478
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    7. XM_030242000.2XP_030097860.1  RAC-beta serine/threonine-protein kinase isoform X1

      Related
      ENSMUSP00000132141.1
      Conserved Domains (2) summary
      cd05595
      Location:156478
      STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
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