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    ADCYAP1 adenylate cyclase activating polypeptide 1 [ Homo sapiens (human) ]

    Gene ID: 116, updated on 8-Jul-2018
    Official Symbol
    ADCYAP1provided by HGNC
    Official Full Name
    adenylate cyclase activating polypeptide 1provided by HGNC
    Primary source
    HGNC:HGNC:241
    See related
    Ensembl:ENSG00000141433 MIM:102980; Vega:OTTHUMG00000131479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PACAP
    Summary
    This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
    Expression
    Biased expression in appendix (RPKM 6.6), brain (RPKM 5.7) and 11 other tissues See more
    Orthologs
    See ADCYAP1 in Genome Data Viewer
    Location:
    18p11.32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 18 NC_000018.10 (904384..912172)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (904366..912173)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene bolA family member 2 pseudogene 1 Neighboring gene proteasome 26S subunit, non-ATPase 8 pseudogene Neighboring gene long intergenic non-protein coding RNA 1904 Neighboring gene uncharacterized LOC107985165

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat PACAP27-induced release of CCL5 inhibits HIV-1 Tat-mediated toxicity in human astrocytes PubMed

    Go to the HIV-1, Human Interaction Database

    • Activation of TRKA receptors, organism-specific biosystem (from REACTOME)
      Activation of TRKA receptors, organism-specific biosystemTrk receptors can either be activated by neurotrophins or by two G-protein-coupled receptors (GPCRs) although the biological relevance of GPCRs remains to be shown.
    • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
      Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
    • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Glucagon-type ligand receptors, organism-specific biosystem (from REACTOME)
      Glucagon-type ligand receptors, organism-specific biosystemThe glucagon hormone family regulates the activity of GPCRs from the secretin receptor subfamily in Class II/B (Mayo KE et al, 2003).
    • Insulin secretion, organism-specific biosystem (from KEGG)
      Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • NGF-independant TRKA activation, organism-specific biosystem (from REACTOME)
      NGF-independant TRKA activation, organism-specific biosystemTRK receptors can also be activated by at least two G-protein-coupled receptors (GPCR), the adenosine A2a receptor and the PACAP type I receptor, without involvement of neurotrophins. Activity of bo...
    • Renin secretion, organism-specific biosystem (from KEGG)
      Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Renin secretion, conserved biosystem (from KEGG)
      Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
      Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC126852

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuropeptide hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptide hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    pituitary adenylate cyclase activating polypeptide activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    pituitary adenylate cyclase activating polypeptide activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pituitary adenylate cyclase-activating polypeptide receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    pituitary adenylate cyclase-activating polypeptide receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ATP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    activation of adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    behavioral fear response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cAMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    camera-type eye development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to glucocorticoid stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to glucocorticoid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    female pregnancy TAS
    Traceable Author Statement
    more info
    PubMed 
    histamine secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histamine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    insulin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of acute inflammatory response to antigenic stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of acute inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of acute inflammatory response to non-antigenic stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of acute inflammatory response to non-antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of glial cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of glial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of muscle cell apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of potassium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ovarian follicle development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    pituitary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    pituitary gland development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of blood vessel diameter IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of blood vessel diameter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cAMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chemokine (C-C motif) ligand 5 production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of chemokine (C-C motif) ligand 5 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of growth hormone secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of growth hormone secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-6 production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of somatostatin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of somatostatin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of G-protein coupled receptor protein signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of G-protein coupled receptor protein signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of oligodendrocyte progenitor proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of oligodendrocyte progenitor proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of pain IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell body fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    perikaryon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    terminal bouton IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    pituitary adenylate cyclase-activating polypeptide
    Names
    adenylate cyclase activating polypeptide 1 (pituitary)
    prepro-PACAP

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099733.1NP_001093203.1  pituitary adenylate cyclase-activating polypeptide preproprotein

      See identical proteins and their annotated locations for NP_001093203.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AP000894, BC093837, DC320719
      Consensus CDS
      CCDS11825.1
      UniProtKB/Swiss-Prot
      P18509
      Related
      ENSP00000411658.3, OTTHUMP00000258653, ENST00000450565.7, OTTHUMT00000440764
      Conserved Domains (2) summary
      smart00070
      Location:83109
      GLUCA; Glucagon like hormones
      pfam00123
      Location:132158
      Hormone_2; Peptide hormone
    2. NM_001117.4NP_001108.2  pituitary adenylate cyclase-activating polypeptide preproprotein

      See identical proteins and their annotated locations for NP_001108.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AP000894, BC093837, DA145895
      Consensus CDS
      CCDS11825.1
      UniProtKB/Swiss-Prot
      P18509
      Related
      ENSP00000462647.1, OTTHUMP00000258654, ENST00000579794.1, OTTHUMT00000440765
      Conserved Domains (2) summary
      smart00070
      Location:83109
      GLUCA; Glucagon like hormones
      pfam00123
      Location:132158
      Hormone_2; Peptide hormone

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p12 Primary Assembly

      Range
      904384..912172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258081.4XP_005258138.2  pituitary adenylate cyclase-activating polypeptide isoform X1

      Conserved Domains (2) summary
      smart00070
      Location:222248
      GLUCA; Glucagon like hormones
      pfam00123
      Location:271297
      Hormone_2; Peptide hormone
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